首页 > 快讯 > 快讯详情 中国科学院武汉病毒研究所:可口服核苷类前药VV261能有效抑制基孔肯雅病毒复制 2026-02-12 格隆汇2月12日|据中国科学院武汉病毒研究所消息,近日,中国科学院武汉病毒研究所肖庚富/张磊砢研究员团队联合上海药物研究所沈敬山研究员团队在学术期刊Signal Transduction and Targeted Therapy上发表了题为“Investigation of a clinical trial drug VV261 as a potent antiviral candidate against Chikungunya virus”的研究进展,该成果筛选出一种已进入临床研究的可口服核苷类前药VV261,能有效抑制基孔肯雅病毒复制。VV261前期已进入一期临床试验用于治疗大别班达病毒感染,此次研究成果为扩展该候选药物的新适应症提供了重要支持。相关实验在中国科学院武汉国家生物安全实验室完成。
msft MSFT Stock Risks Breakdown If Support Goes, as Microsoft’s AI Costs Surge While Microsoft’s AI strategy continues to drive growth, escalating investment costs and valuation pressures are prompting investors to... Written by: Skerdian Meta • • 3 min read • Quick overview Microsoft's stock has declined below $400 amid rising concerns over AI investment costs and profitability. Despite strong Az...
msft MSFT Stock Risks Breakdown If Support Goes, as Microsoft’s AI Costs Surge While Microsoft’s AI strategy continues to drive growth, escalating investment costs and valuation pressures are prompting investors to... Written by: Skerdian Meta • • 3 min read • Quick overview Microsoft's stock has declined below $400 amid rising concerns over AI investment costs and profitability. Despite strong Azure growth and an earnings beat, investor focus has shifted to the sustainability of Microsoft's capital expenditures. A recent downgrade by an analyst has prompted a reevaluation of Microsoft's future growth potential and valuation. The company's significant capital spending on AI infrastructure raises questions about margin compression and the timing of monetization. Live MSFT Chart 0.0000 MARKETS TREND [[MSFT-graph]] While Microsoft’s AI strategy continues to drive growth, escalating investment costs and valuation pressures are prompting investors to reassess the balance between ambition and near-term profitability. Escalating AI Costs Renew Selling Pressure Microsoft shares have resumed their decline, slipping back under the $400 level after a steep sell-off rattled investors. The weakness comes despite another earnings beat, underscoring how market focus has shifted from headline results to forward-looking concerns about capital intensity and margin durability. The central issue is not demand—Azure growth remains strong and enterprise adoption of AI tools continues to expand. Instead, the debate revolves around how much Microsoft must spend to secure its position in the AI arms race, and how long it will take for those investments to translate into sustainable profit expansion. As AI infrastructure spending accelerates, investors are increasingly questioning whether near-term returns justify the scale of outlays. A Valuation Reset Sparks a Technical Bounce Following the sharp drop below $400, several analysts characterized Microsoft’s pricing as deeply oversold. The br...
Companies like SoundHound have been on the decline as the artificial intelligence hype has begun to cool, but Palantir has real staying power. Artificial intelligence (AI) is perhaps the biggest story to hit the stock market since the internet 20 years ago. AI stocks have had an incredible bull run collectively over the past few years. But now the hype is beginning to cool, and simply being an AI ...
Companies like SoundHound have been on the decline as the artificial intelligence hype has begun to cool, but Palantir has real staying power. Artificial intelligence (AI) is perhaps the biggest story to hit the stock market since the internet 20 years ago. AI stocks have had an incredible bull run collectively over the past few years. But now the hype is beginning to cool, and simply being an AI company isn't enough to draw in investor dollars anymore. For proof, look no further than SoundHound AI. Since its stock's most recent peak at about $20 in October 2025, it has lost over half its value and is trading at $8.50 at the time of this writing. But not every AI name is struggling. Palantir Technologies (PLTR 2.66%) released some fantastic fourth-quarter and full-year 2025 results recently, and over the past 12 months, its shares are up 29%. So we're beginning to see which AI companies are starting to flounder and which have real staying power. Palantir is the second kind, so let's look at its special sauce. The military's crystal ball Palantir gets its name from the seeing stones of J.R.R. Tolkien's legendarium. In his books, they allowed their user to see far-away events or communicate instantaneously across vast distances. That's essentially what the company does for its clients, chief among them the U.S. government. Its Gotham software essentially puts all the information available about a battlefield into a single interface . Its Maven Smart System (MSS) is a platform specifically designed for the U.S. military for intelligence analysis. In August 2025, the Army signed a contract with Palantir that could be worth up to $10 billion over the next decade. Then, in September, the Marine Corps acquired a new enterprise license from the company to deploy the MSS across the branch. There is no disclosed dollar agreement for the Marine Corps contract. But based on a previous $480 million five-year agreement with the Department of Defense for MSS from 2024 (for which t...
The portable generator leader is now an AI play. Shares of Generac (GNRC +17.79%) popped on Wednesday after the energy solutions provider issued an encouraging, artificial intelligence (AI)-powered growth forecast. By the close of trading, Generac's stock price was up more than 17%. A booming new market Generac's fourth-quarter net sales fell 12% year over year to $1.1 billion. Fewer power outages...
The portable generator leader is now an AI play. Shares of Generac (GNRC +17.79%) popped on Wednesday after the energy solutions provider issued an encouraging, artificial intelligence (AI)-powered growth forecast. By the close of trading, Generac's stock price was up more than 17%. A booming new market Generac's fourth-quarter net sales fell 12% year over year to $1.1 billion. Fewer power outages led to lower shipments of portable generators. The energy technology specialist's residential product sales, in turn, declined by 23% to $572 million. However, Generac's commercial and industrial product revenue jumped 10% to $400 million, driven by higher sales to data center customers. "Our momentum in the data center end market has further accelerated as we continue to develop our position as a key supplier to multiple hyperscale customers, which are expected to add significant volumes to our backlog over the next several quarters," CEO Aaron Jagdfeld said in a press release. Expand NYSE : GNRC Generac Today's Change ( 17.79 %) $ 32.43 Current Price $ 214.73 Key Data Points Market Cap $11B Day's Range $ 190.00 - $ 220.66 52wk Range $ 99.50 - $ 220.85 Volume 272K Avg Vol 1.1M Gross Margin 37.15 % All told, Generac generated adjusted net income of $95 million, or $1.61 per share. That's down from $168 million, or $2.80 per share, in the prior-year quarter. Profits are set to rebound Generac sees full-year sales growth in the mid-teens percent range in 2026. Normalized power outage activity is projected to drive a 10% increase in residential product sales. Management also expects commercial and industrial sales to grow by a solid 30%, as Generac ramps up its data center business. "We are focused on dramatically increasing our capacity and capabilities for large megawatt generators, including the purchase of an additional manufacturing facility in Wisconsin in the fourth quarter and ongoing investments in our existing facilities around the world," Jagdfeld said. "These oppo...
(MSFT) Investment Strategy and Analysis Trading Plans (Long Term) No Long plans offered at this time. Short near 31.57, target n/a, stop loss @ 31.73 Check the time stamp on this data. Updated AI-Generated Signals for Microsoft CDR (CAD Hedged) (MSFT:CA) available here. MSFT:CA Ratings for February 11: Term Near Mid Long Rating Neutral Weak Neutral â Triggers may have already come Get Real Time T...
(MSFT) Investment Strategy and Analysis Trading Plans (Long Term) No Long plans offered at this time. Short near 31.57, target n/a, stop loss @ 31.73 Check the time stamp on this data. Updated AI-Generated Signals for Microsoft CDR (CAD Hedged) (MSFT:CA) available here. MSFT:CA Ratings for February 11: Term Near Mid Long Rating Neutral Weak Neutral â Triggers may have already come Get Real Time Triggers Here.
The Dutch writer Cees Nooteboom, whose novels, travel writing and translations made him a prominent literary figure in postwar Europe, has died aged 92. Publishing house De Bezige Bij said in a statement on Wednesday evening that Nooteboom had “passed away very peacefully on his beloved island Menorca”. The statement was made on behalf of the author’s wife, the photographer Simone Sassen. “We will...
The Dutch writer Cees Nooteboom, whose novels, travel writing and translations made him a prominent literary figure in postwar Europe, has died aged 92. Publishing house De Bezige Bij said in a statement on Wednesday evening that Nooteboom had “passed away very peacefully on his beloved island Menorca”. The statement was made on behalf of the author’s wife, the photographer Simone Sassen. “We will miss the friendship, erudition, enthusiasm and individuality of this internationally acclaimed writer,” it said. Nooteboom first made a name for himself in the Netherlands with his 1955 debut novel Philip and the Others. Based on long hitchhiking trips to the Mediterranean and through Scandinavia, it won the Anne Frank prize and became a Dutch literary classic. He achieved his international breakthrough with his 1980 novel Rituals, about two friends – one of whom breaks rules frequently while the other follows them strictly. The book was turned into a film in 1988 and became his first work to be published in English translation. Born in The Hague on 31 July 1933, Nooteboom told the Guardian in a 2006 interview that he had no childhood memories until the outbreak of the second world war. When Germany invaded the Netherlands in 1940, “we watched on the horizon the glow of Rotterdam burning and I remember being very afraid and having to have cold water thrown in my face to calm me down”. His father was later killed when a British air raid levelled a residential quarter of The Hague “by mistake”. Germany was later one of the European countries were Nooteboom’s fiction and travel writing found even greater critical acclaim and commercial success than at home. As well as writing his own work, Nooteboom translated works from English into Dutch, such as poetry by Ted Hughes and Czesław Miłosz, and the plays of Brendan Behan and Seán O’Casey. He was awarded honorary doctorates from universities in Brussels, Nijmegen, Berlin and, in 2019, the University College London.
Will the 40-point mark - or thereabouts - be needed to guarantee survival this term, with an in-form West Ham attempting to chase down the sides above them?
Will the 40-point mark - or thereabouts - be needed to guarantee survival this term, with an in-form West Ham attempting to chase down the sides above them?
AppLovin NASDAQ: APP executives used the company’s fourth-quarter earnings call to push back on investor concerns about competition and artificial intelligence, while highlighting a sharp year-over-year acceleration in revenue, profitability, and free cash flow. Co-founder and CEO Adam Foroughi said recent stock volatility has been driven by worries that AI and new entrants could pressure the busi...
AppLovin NASDAQ: APP executives used the company’s fourth-quarter earnings call to push back on investor concerns about competition and artificial intelligence, while highlighting a sharp year-over-year acceleration in revenue, profitability, and free cash flow. Co-founder and CEO Adam Foroughi said recent stock volatility has been driven by worries that AI and new entrants could pressure the business, but he argued internal performance data shows the “strongest operating performance” in the company’s history. Get AppLovin alerts: Sign Up Management addresses competition and AI narratives Foroughi said AppLovin has “never feared competition,” framing the company’s MAX auction as a foundational component of the mobile gaming ecosystem. He argued that rising bid density can expand the overall “pie,” even if AppLovin wins a smaller share of impressions, because the company can collect a fee when other bidders win inventory that AppLovin’s model values less. In his view, improving auction competition helps publishers earn more, which supports more user acquisition and overall ecosystem growth. On AI’s impact on game creation, Foroughi rejected the notion that easier game development would reduce the value of AppLovin’s platform. Instead, he said lower creation costs should increase content supply, making discovery scarcer and more valuable. He positioned AppLovin’s models as designed to match users to content “at the right moment,” and said the company sees ongoing opportunity because it still converts only a small portion of the impressions it serves. Q4 and full-year results: growth, margins, and cash flow CFO Matt Stumpf reported fourth-quarter revenue of $1.66 billion, up 66% year-over-year, driven by technology improvements in mobile gaming, seasonal strength, and the growing impact of the company’s e-commerce initiative. Adjusted EBITDA was $1.4 billion, up 82% year-over-year, representing an 84% margin. Stumpf said margins expanded more than 700 basis points from...
Image source: The Motley Fool. Wednesday, Feb. 11, 2026 at 5 p.m. ET Call participants Chairman and Chief Executive Officer — Gregory Q. Brown Chief Financial Officer — Jason J. Winkler Executive Vice President and Chief Technology Officer — Mahesh Saptharishi Corporate Vice President, Investor Relations — Tim Yocum Corporate Vice President, Products and SI — Jack Molloy Corporate Vice President, ...
Image source: The Motley Fool. Wednesday, Feb. 11, 2026 at 5 p.m. ET Call participants Chairman and Chief Executive Officer — Gregory Q. Brown Chief Financial Officer — Jason J. Winkler Executive Vice President and Chief Technology Officer — Mahesh Saptharishi Corporate Vice President, Investor Relations — Tim Yocum Corporate Vice President, Products and SI — Jack Molloy Corporate Vice President, Software and Services — Tomer Zilberman Need a quote from a Motley Fool analyst? Email [email protected] Takeaways Revenue -- up 12% for the quarter with double-digit growth in both Products and SI and Software and Services segments, supported by $188 million from acquisitions and a $30 million FX tailwind. -- up 12% for the quarter with double-digit growth in both Products and SI and Software and Services segments, supported by $188 million from acquisitions and a $30 million FX tailwind. Full-year Revenue -- $11.7 billion, up 8%, with $382 million contributed by acquisitions and a $35 million FX benefit. -- $11.7 billion, up 8%, with $382 million contributed by acquisitions and a $35 million FX benefit. GAAP Operating Earnings -- $944 million for the quarter (27.9% of sales), and $3 billion for the year (25.6% of sales). -- $944 million for the quarter (27.9% of sales), and $3 billion for the year (25.6% of sales). Non-GAAP Operating Earnings -- $1.1 billion for the quarter (record 32.1% margin), and $3.5 billion for the year (record 30.3% margin). -- $1.1 billion for the quarter (record 32.1% margin), and $3.5 billion for the year (record 30.3% margin). Non-GAAP EPS -- $4.59 for the quarter, up 14%; $15.38 for the year, up 11%. -- $4.59 for the quarter, up 14%; $15.38 for the year, up 11%. Operating Cash Flow -- $1.3 billion for the quarter, $2.8 billion for the year, representing a 19% annual increase. -- $1.3 billion for the quarter, $2.8 billion for the year, representing a 19% annual increase. Free Cash Flow -- $2.6 billion for the year, up 21%. -- $2.6 billion for t...
(NVDA) Trading Signals Trading Plans (Long Term) Buy near 35.70, target n/a, stop loss @ 35.52 No Short plans offered at this time. Check the time stamp on this data. Updated AI-Generated Signals for Nvidia CDR (CAD Hedged) (NVDA:CA) available here. NVDA:CA Ratings for February 11: Term Near Mid Long Rating Strong Weak Strong â Triggers may have already come Get Real Time Triggers Here.
(NVDA) Trading Signals Trading Plans (Long Term) Buy near 35.70, target n/a, stop loss @ 35.52 No Short plans offered at this time. Check the time stamp on this data. Updated AI-Generated Signals for Nvidia CDR (CAD Hedged) (NVDA:CA) available here. NVDA:CA Ratings for February 11: Term Near Mid Long Rating Strong Weak Strong â Triggers may have already come Get Real Time Triggers Here.
Stocks @ Night is a daily newsletter delivered after hours, giving you a first look at tomorrow and last look at today. Sign up for free to receive it directly in your inbox. Here's what CNBC TV's producers were watching as the Dow Industrials broke a three-day win streak, and what's on the radar for the next session. Prime pain Amazon posted its seventh straight losing session. The stock has drop...
Stocks @ Night is a daily newsletter delivered after hours, giving you a first look at tomorrow and last look at today. Sign up for free to receive it directly in your inbox. Here's what CNBC TV's producers were watching as the Dow Industrials broke a three-day win streak, and what's on the radar for the next session. Prime pain Amazon posted its seventh straight losing session. The stock has dropped 16% during the streak — its worst seven-day stretch since November 2022, according to CNBC data and analytics producer Nick Wells. Another decline Thursday would tie its longest losing streak since an eight-day slide in 2019. AMZN 5D mountain Amazon shares in the past five days Serving up a beat McDonald's earnings and revenue beat analyst expectations as its value push helped win back customers. Shares are within 2% of their all-time high. Still, the stock is on track to snap a five-week winning streak — matching a run last seen in August. High energy Energy is the best-performing sector of the year, up more than 20%. The State Street Energy Select Sector SPDR ETF (XLE) notched another all-time high on Wednesday. ExxonMobil hit a fresh intraday record as Chevron climbed to a new 52-week high. XLE YTD mountain The State Street Energy Select Sector SPDR ETF (XLE) in 2026 The read on retail Thursday morning's earnings should offer a fresh read on the consumer. Since its 2025 closing high, Birkenstock has erased a third of its value. Hermès shares are flat this year — outperforming rival LVMH, which is down 18% in 2026. Crocs has fallen nearly 30% over the past three years. COIN flip Coinbase is set to report earnings after the bell. Shares have been battered amid the crypto meltdown. The stock has plunged more than 60% from its record close in July. It's on pace for a fourth straight losing month, a streak last seen in 2022. COIN 3M mountain Coinbase in the past three months WYNN or go home Wynn Resorts will report quarterly results Thursday afternoon. Shares are off to a...
Image source: The Motley Fool. Wednesday, Feb. 11, 2026 at 5 p.m. ET CALL PARTICIPANTS Chief Executive Officer — Aaron M. Erter Chief Financial Officer — Ryan Lada President and General Manager, North America Building Products Group — Jonathan Skelly Chief Sales Officer — John Matson Chief Operating Officer — Christopher Russell TAKEAWAYS Total Net Sales -- $1.24 billion, up 30%, with $275 million...
Image source: The Motley Fool. Wednesday, Feb. 11, 2026 at 5 p.m. ET CALL PARTICIPANTS Chief Executive Officer — Aaron M. Erter Chief Financial Officer — Ryan Lada President and General Manager, North America Building Products Group — Jonathan Skelly Chief Sales Officer — John Matson Chief Operating Officer — Christopher Russell TAKEAWAYS Total Net Sales -- $1.24 billion, up 30%, with $275 million from acquired AZEK sales. -- $1.24 billion, up 30%, with $275 million from acquired AZEK sales. Organic Sales Growth -- 1% organic sales increase; adjusted EBITDA $330 million, with a 26.6% margin. -- 1% organic sales increase; adjusted EBITDA $330 million, with a 26.6% margin. Free Cash Flow -- Year-to-date free cash flow reached $261 million, including land sale proceeds in Australia; management expects full-year free cash flow of at least $200 million, noting timing factors and integration costs. -- Year-to-date free cash flow reached $261 million, including land sale proceeds in Australia; management expects full-year free cash flow of at least $200 million, noting timing factors and integration costs. Net Debt & Leverage -- Net debt ended at $4.3 billion; pro forma net leverage stands near 3x, with an explicit target to reduce below 2x within two years. -- Net debt ended at $4.3 billion; pro forma net leverage stands near 3x, with an explicit target to reduce below 2x within two years. Siding and Trim Segment -- Net sales advanced 10% with $81 million from AZEK; organic net sales declined 2% with a mid-single-digit improvement in average sales price; adjusted EBITDA was $269 million at a 34.1% margin; year-over-year margin decrease of 70 basis points attributed to a 100 basis point hit from a $9 million R&D allocation. -- Net sales advanced 10% with $81 million from AZEK; organic net sales declined 2% with a mid-single-digit improvement in average sales price; adjusted EBITDA was $269 million at a 34.1% margin; year-over-year margin decrease of 70 basis points attribu...
The AI boom is bringing a lot of energy to utility stocks. Utilities used to be boring, defensive investments, but with the rise of AI-related demand, that is no longer the case. Data centers and industrial electrification are changing how investors view utility stocks. Two major players that are very much in the mix are Constellation Energy (CEG +2.17%) and Vistra (VST +0.47%). One company offers...
The AI boom is bringing a lot of energy to utility stocks. Utilities used to be boring, defensive investments, but with the rise of AI-related demand, that is no longer the case. Data centers and industrial electrification are changing how investors view utility stocks. Two major players that are very much in the mix are Constellation Energy (CEG +2.17%) and Vistra (VST +0.47%). One company offers greater stability, whereas the other could potentially have more upside. Which stock is better, though? Let's dive in and find out. Expand NASDAQ : CEG Constellation Energy Today's Change ( 2.17 %) $ 5.87 Current Price $ 277.01 Key Data Points Market Cap $85B Day's Range $ 268.34 - $ 277.53 52wk Range $ 161.35 - $ 412.70 Volume 146K Avg Vol 3.1M Gross Margin 19.30 % Dividend Yield 0.57 % Constellation is carbon-free and predictable Constellation Energy is the largest producer of carbon-free electricity in the U.S. Its biggest revenue drivers are its long-term power contracts and the rising demand for clean energy, particularly for use in data centers. Constellation Energy has a steady cash flow and a diversified portfolio including nuclear, natural gas, and renewable energy. Last quarter, Constellation's earnings were mixed. Constellation brought in $930 million in net income, which was a decrease from the same quarter last year. However, adjusted operating earnings improved from $860 million in the third quarter of 2024 to $952 million in 2025. Constellation's stock is down substantially to start 2026, having declined more than 23% as of Feb. 9. Overall, the power company continues to provide long-term predictability, but could use a bit more operational efficiency to improve profitability metrics. For income investors, Constellation pays a consistent annual dividend of $1.55 per share. Vistra is volatile but ambitious Vistra is a bit more diversified and opportunistic in its operations. The Texas-based power company offers natural gas, nuclear, and renewable assets, but ...
Long Term Trading Analysis for (GOOG) Trading Plans (Long Term) Buy near 47.87, target 52.55, stop loss @ 47.63 Short near 52.55, target 47.87, stop loss @ 52.81 Check the time stamp on this data. Updated AI-Generated Signals for Alphabet CDR (CAD Hedged) (GOOG:CA) available here. GOOG:CA Ratings for February 11: Term Near Mid Long Rating Weak Neutral Strong â Triggers may have already come Get R...
Long Term Trading Analysis for (GOOG) Trading Plans (Long Term) Buy near 47.87, target 52.55, stop loss @ 47.63 Short near 52.55, target 47.87, stop loss @ 52.81 Check the time stamp on this data. Updated AI-Generated Signals for Alphabet CDR (CAD Hedged) (GOOG:CA) available here. GOOG:CA Ratings for February 11: Term Near Mid Long Rating Weak Neutral Strong â Triggers may have already come Get Real Time Triggers Here.