Earnings Call Insights: Sangamo Therapeutics (SGMO) Q4 2025 Management View CEO Alexander Macrae stated that "Sangamo continued to make significant pipeline progress in 2025 and into the first quarter of '26. Set against a backdrop of regulatory and market uncertainty and with limited cash resources." He highlighted positive top line results from the registrational STAAR study in Fabry disease, wi...
Earnings Call Insights: Sangamo Therapeutics (SGMO) Q4 2025 Management View CEO Alexander Macrae stated that "Sangamo continued to make significant pipeline progress in 2025 and into the first quarter of '26. Set against a backdrop of regulatory and market uncertainty and with limited cash resources." He highlighted positive top line results from the registrational STAAR study in Fabry disease, with eGFR slope at 52 weeks, and confirmed that the FDA reiterated this may serve as the primary basis for accelerated approval. Macrae reported that the rolling submission of a BLA to the FDA for ST-920, Sangamo's first wholly owned BLA, is in progress. Sangamo has also transitioned to a clinical stage neurology company, activating six clinical sites in the Phase I/II STAND study for chronic neuropathic pain. Macrae announced a third neurology capsid license agreement, this time with Eli Lilly, to deliver genomic medicines for up to five CNS disease targets. The company has raised over $130 million since the start of 2025 through nondilutive license fees, milestone payments, and equity financing. Nathalie Dubois-Stringfellow, Chief Development Officer, stated, "We have now submitted both the nonclinical and the clinical modules to the FDA. In addition, the antibody assay companion diagnostic...has been submitted to and accepted by the FDA Center for Devices and Radiological Health." She added that the next milestone is completion of the chemistry, manufacturing, and controls (CMC) module, with manufacturing and testing of process validation lots completed and the first commercial lot manufactured. Outlook Macrae indicated that Sangamo anticipates "completing submission of the BLA as early as this summer, subject to our ability to secure adequate additional funding." The company continues to seek a commercial partner for Fabry, which remains the top priority, with ongoing discussions involving multiple potential partners. Macrae described the process as complex and requiring ...
keni1/iStock via Getty Images Peabody Energy ( BTU ) sank 9.6% in Monday's trading after saying it expects Q1 sales volume from its Centurion mine in Australia will come in below prior expectations , anticipating ~250K tons compared with prior forecasts of ~700K tons, based on greater-than-expected challenges in commissioning of the mines. Despite the revised forecast, Peabody ( BTU ) said its FY ...
keni1/iStock via Getty Images Peabody Energy ( BTU ) sank 9.6% in Monday's trading after saying it expects Q1 sales volume from its Centurion mine in Australia will come in below prior expectations , anticipating ~250K tons compared with prior forecasts of ~700K tons, based on greater-than-expected challenges in commissioning of the mines. Despite the revised forecast, Peabody ( BTU ) said its FY 2026 metallurgical coal volume targets remain unchanged at 10.3M-11.3M tons. Jefferies analysts maintained a Buy rating on Peabody ( BTU ) shares, citing high seaborne thermal coal prices as a potential offset to the impact of the shipment delay. "High seaborne thermal coal prices will help offset the impact of this ramp-up delay, but this is still likely to be an overhang on BTU shares until it is fully resolved," Jefferies analyst Christopher LaFemina said in a note, adding that a successful ramp of Centurion is a "key component of the Peabody investment case." "While today's news may be disappointing, we still believe Centurion will be a driver of substantial free cash flow and earnings growth for Peabody over the medium/longer term," LaFemina wrote. Coal companies that produce thermal coal, which is used for power generation, have been gaining recently as investors reprice demand for coal as a heating source because prices for oil and natural gas are rising in response to the Middle East war; Newcastle coal futures settled Monday at $144.25/ton, its best close since November 2024 and up 23% in March, according to Dow Jones. More on Peabody Energy Peabody Energy Presents at 35th BMO Global Metals, Mining & Critical Minerals Conference - Slideshow Peabody: Trump's Coal Policy Does Not Affect Coal Market Fundamentals Peabody Energy: Decent Q4 2025 And Centurion Ahead Of Schedule (Downgrade)
The S&P 500 Index ($SPX ) (SPY ) on Monday closed down -0.39%, the Dow Jones Industrial Average ($DOWI ) (DIA ) closed up +0.11%, and the Nasdaq 100 Index ($IUXX ) (QQQ ) closed down -0.78%. June E-mini S&P futures (ESM26 ) fell -0.43%, and June E-mini Nasdaq futures...
The S&P 500 Index ($SPX ) (SPY ) on Monday closed down -0.39%, the Dow Jones Industrial Average ($DOWI ) (DIA ) closed up +0.11%, and the Nasdaq 100 Index ($IUXX ) (QQQ ) closed down -0.78%. June E-mini S&P futures (ESM26 ) fell -0.43%, and June E-mini Nasdaq futures...
For three decades, the web has existed in a state of architectural denial. It is a platform originally conceived to share static physics papers, yet it is now tasked with rendering the most complex, interactive, and generative interfaces humanity has ever conceived. At the heart of this tension lies a single, invisible, and prohibitively expensive operation known as " layout reflow. " Whenever a d...
For three decades, the web has existed in a state of architectural denial. It is a platform originally conceived to share static physics papers, yet it is now tasked with rendering the most complex, interactive, and generative interfaces humanity has ever conceived. At the heart of this tension lies a single, invisible, and prohibitively expensive operation known as " layout reflow. " Whenever a developer needs to know the height of a paragraph or the position of a line to build a modern interface, they must ask the browser’s Document Object Model (DOM) , the standard by which developers can create and modify webpages. In response, the browser often has to recalculate the geometry of the entire page — a process akin to a city being forced to redraw its entire map every time a resident opens their front door. L ast Friday, March 27, 2026, Cheng Lou — a prominent software engineer whose work on React, ReScript, and Midjourney has defined much of the modern frontend landscape — announced on the social network X that he had "crawled through depths of hell" to release an open source (MIT License) solution: Pretext , which he coded using AI vibe coding tools and models like OpenAI's Codex and Anthropic's Claude. It is a 15KB, zero-dependency TypeScript library that allows for multiline text measurement and layout entirely in "userland," bypassing the DOM and its performance bottlenecks. Without getting too technical, in short, Lou's pretext turns text blocks on the web into fully dynamic, interactive and responsive spaces, able to adapt and smoothly move around any other object on a webpage, preserving letter order and spaces between words and lines, even when a user clicks and drags other objects to intersect with the text, or resizes their browser window dramatically. Ironically, it's difficult with mere text alone to convey how significant Lou's latest release is for the entire web going forward. Fortunately, other developers whipped up quick demoes with Pretext showin...
Patrick K. Craine, CLAO and Corporate Secretary of Gulfport Energy Corporation (NYSE:GPOR) , disclosed the sale of 2,000 shares of common stock in open-market transactions on March 5, 2026, for a total value of approximately $418,000, according to a SEC Form 4 filing . Transaction value based on SEC Form 4 weighted average purchase price ($209.09); post-transaction value based on March 5, 2026 mar...
Patrick K. Craine, CLAO and Corporate Secretary of Gulfport Energy Corporation (NYSE:GPOR) , disclosed the sale of 2,000 shares of common stock in open-market transactions on March 5, 2026, for a total value of approximately $418,000, according to a SEC Form 4 filing . Transaction value based on SEC Form 4 weighted average purchase price ($209.09); post-transaction value based on March 5, 2026 market close ($209.09). * 1-year performance is calculated using March 27 th, 2026 as the reference date. Continue reading