Eoneren/E+ via Getty Images U.S. large-cap healthcare stocks have delivered modest year-to-date gains in 2026, holding steady into March amid its defensive appeal. Below is a list of the top 10 large-cap healthcare stocks with market capitalizations of $10B or more, ranked by their year-to-date performance. The list is topped by Moderna, Inc. ( MRNA ), with a YTD performance of 73.89%. DaVita Inc....
Eoneren/E+ via Getty Images U.S. large-cap healthcare stocks have delivered modest year-to-date gains in 2026, holding steady into March amid its defensive appeal. Below is a list of the top 10 large-cap healthcare stocks with market capitalizations of $10B or more, ranked by their year-to-date performance. The list is topped by Moderna, Inc. ( MRNA ), with a YTD performance of 73.89%. DaVita Inc. ( DVA ) and Revolution Medicines, Inc. ( RVMD ) are next, rounding out the top three performers in the sector. Royalty Pharma plc ( RPRX ), The Ensign Group, Inc. ( ENSG ), and Align Technology, Inc. ( ALGN ) are among the other significant contributors to the healthcare sector’s YTD leaders. These companies span various healthcare industries including pharmaceuticals, health care facilities, and health care supplies. Here is the list: Moderna, Inc. ( MRNA ), YTD perf: 73.89%, Quant rating: 3.43 DaVita Inc. ( DVA ), YTD perf: 33.98%, Quant rating: 4.81 Revolution Medicines, Inc. ( RVMD ), YTD perf: 21.32%, Quant rating: 3.23 Royalty Pharma plc ( RPRX ), YTD perf: 18.04%, Quant rating: 3.08 The Ensign Group, Inc. ( ENSG ), YTD perf: 16.21%, Quant rating: 3.37 Align Technology, Inc. ( ALGN ), YTD perf: 15.82%, Quant rating: 3.40 Quest Diagnostics Incorporated ( DGX ), YTD perf: 12.72%, Quant rating: 3.27 Gilead Sciences, Inc. ( GILD ), YTD perf: 11.90%, Quant rating: 3.23 Elanco Animal Health Incorporated ( ELAN ), YTD perf: 8.00%, Quant rating: 3.24 Penumbra, Inc. ( PEN ), YTD perf: 7.93%, Quant rating: 3.18 Health Care ETFs: ( XLV ), ( VHT ), ( IHI ), ( IXJ ), ( IYH ), ( FHLC ), and ( FXH ) More on healthcare stocks IHI: Pullback Creates A Buying Opportunity In High-Growth MedTech Routine Vaccines Okay For Now: Investment Implications Of The Court Decision Sector Rotation: Healthcare XLV Should Be The Next Stop Weekly ETF flows: three of 11 sectors record outflows; financial sector leads inflows Notable healthcare headlines for the week: Eli Lilly, Novo Nordisk, and Novart...