mphillips007 PepGen ( PEPG ) shares fell ~44% in after-hours trading after the Massachusetts-based biotech company shared results from a mid-stage trial for its main treatment, PGN-EDODM1, which is aimed at myotonic dystrophy type 1, a rare condition that causes muscle weakness and wasting. The company said that data from the 5 mg/kg multiple ascending dose cohort of its Phase 2 FREEDOM2-DM1 trial...
mphillips007 PepGen ( PEPG ) shares fell ~44% in after-hours trading after the Massachusetts-based biotech company shared results from a mid-stage trial for its main treatment, PGN-EDODM1, which is aimed at myotonic dystrophy type 1, a rare condition that causes muscle weakness and wasting. The company said that data from the 5 mg/kg multiple ascending dose cohort of its Phase 2 FREEDOM2-DM1 trial supported its decision to study PGN-EDODM1 in its ongoing 10 mg/kg dose cohort, which is expected to generate data in H2 2026. However, PepGen ( PEPG ) shares sank, with analysts noting the mixed nature of the readout, which indicated a generally well-tolerated safety profile for the drug but without meaningful improvements in patients' handgrip strength or 10-meter walk/run test. “There were no meaningful improvements in the 10-meter walk/run test or handgrip strength at this dose," Leerink Partners analyst Joseph Schwartz wrote with an Outperform rating on PEPG, according to Bloomberg. “These data support further development, as the removal of an outlier suggests a dose-response between SAD and MAD dosing, and higher doses may increase the responder rate," Schwartz added. However, Oppenheimer analyst Kostas Biliouris argued that the selloff was overdone. “PGN-EDODM1 is active and remains positive in the story," he wrote with an Outperform rating. “In the grand scheme, we still think there’s a drug effect here; this was the low dose, and thus there’s reason to be hopeful that the data may improve at 10 mg/kg," Stifel’s Paul Matteis, who has a Buy rating on PepGen ( PEPG ), added. More on PepGen PepGen Inc. (PEPG) Discusses Topline Results From Lowest Dose MAD Cohort in Phase II FREEDOM2 Study With Favorable Safety, Splicing and vHOT Data - Slideshow PepGen Inc. (PEPG) Discusses Topline Results From Lowest Dose MAD Cohort in Phase II FREEDOM2 Study With Favorable Safety, Splicing and vHOT Data Transcript PepGen: Stock Slides On FDA Study Hold - I'm Firmly On The Sidelines ...
Rasi Bhadramani/iStock via Getty Images Manager perspective and outlook Global macroeconomic conditions during the quarter were characterized by monetary easing, though inflationary pressures persisted across major economies. The US Federal Reserve cut the federal funds rate in October in response to labor market weakness, though inflation remained above target. The European Central Bank approache...
Rasi Bhadramani/iStock via Getty Images Manager perspective and outlook Global macroeconomic conditions during the quarter were characterized by monetary easing, though inflationary pressures persisted across major economies. The US Federal Reserve cut the federal funds rate in October in response to labor market weakness, though inflation remained above target. The European Central Bank approached the end of its interest rate cutting cycle, while the outlook for UK interest rates remained uncertain amid ongoing policy adjustments. Japan's economy grew above trend, with expectations for additional monetary tightening, in contrast to generally accommodative stances elsewhere. Against this backdrop, global listed real estate securities declined for the quarter. Global listed real estate equities ended the quarter trading even with their average underlying net asset value. However, this statistic hid wide dispersions in the valuations of countries and property types. Our outlook for global listed real estate remains cautiously constructive as monetary policy has remained accommodative in major economies. Conditions should be most supportive for markets and sectors that have already experienced valuation declines and where tenant demand can provide a structural tailwind. This is especially true for landlords supplying high quality assets into supply-constrained or higher demand markets and thus commanding pricing power. Top issuers - (% of total market value) Fund Index Welltower Inc ( WELL ) 6.33 6.85 Prologis Inc ( PLD ) 5.68 6.36 Digital Realty Trust Inc ( DLR ) 4.00 2.86 Equinix Inc ( EQIX ) 3.86 4.02 Simon Property Group Inc ( SPG ) 2.97 3.22 Goodman Group 2.81 2.20 Mitsui Fudosan Co Ltd ( MTSFF ) 2.46 1.59 AvalonBay Communities Inc ( AVB ) 2.23 1.38 First Industrial Realty Trust Inc ( FR ) 2.22 0.39 Extra Space Storage Inc ( EXR ) 2.17 1.47 Click to enlarge As of 12/31/25. Holdings are subject to change and are not buy/sell recommendations. Asset mix (%) Dom Commo...
AI Is "New Front Door To Commerce" As Consumers Ditch Google For Chatbots Shoptalk, one of the retail and e-commerce industry's top U.S. conferences, took place in Las Vegas last week, where Goldman analysts had one key takeaway for clients on Monday morning: AI is beginning to reshape how consumers shop. Analysts Brooke Roach and Kate McShane, among others, attended the conference and listened to...
AI Is "New Front Door To Commerce" As Consumers Ditch Google For Chatbots Shoptalk, one of the retail and e-commerce industry's top U.S. conferences, took place in Las Vegas last week, where Goldman analysts had one key takeaway for clients on Monday morning: AI is beginning to reshape how consumers shop. Analysts Brooke Roach and Kate McShane, among others, attended the conference and listened to retailers, consumer brands, and technology vendors focus on the evolving consumer space in the era of AI. Their top takeaway was that AI is emerging as a "new front door to commerce," and instead of beginning product searches on Google or Amazon, an increasing number of consumers are turning to chatbots to decide what to buy. "Brands and retailers noted that consumers are increasingly beginning their shopping journey inside AI platforms rather than on brand websites or search engines, with adoption accelerating rapidly over the past several months," the analyst noted. Here are more takeaways from Goldman's analysts after attending Shoptalk: The front door to commerce is shifting to AI Brands and retailers noted that consumers are increasingly beginning their shopping journey inside AI platforms rather than on brand websites or search engines, with adoption accelerating rapidly over the past several months. GAP stated it is seeing stronger purchase intent and higher conversion from customers arriving through agentic channels, and described itself as explicitly not in a wait-and-see mode. The company also noted it is an early partner on Google's Universal Commerce Protocol, which allows the merchant to bring its own experience including loyalty, promotions, and cart capabilities directly into LLM environments, rather than pushing users to a generic external destination. Enhancing consumer relevance and enabling product research / purchase decisions Brands noted that becoming relevant within LLMs is a different challenge from search engine optimization, as LLM crawlers ingest...
The best-performing stocks typically have robust sales growth, increasing margins, and rising returns on capital, and those that can maintain this trifecta year in and year out often become the legends of the investing world.
The best-performing stocks typically have robust sales growth, increasing margins, and rising returns on capital, and those that can maintain this trifecta year in and year out often become the legends of the investing world.