Tom Werner/DigitalVision via Getty Images I am optimistic about Relay Therapeutics ( RLAY ). I believe the current stock price reflects the view that Relay is a single-asset, clinical-stage oncology story. However, what Relay is showing is more interesting: how one well-established drug design concept can be applied across multiple high-value patient needs. Relay is not just trying to create anoth...
Tom Werner/DigitalVision via Getty Images I am optimistic about Relay Therapeutics ( RLAY ). I believe the current stock price reflects the view that Relay is a single-asset, clinical-stage oncology story. However, what Relay is showing is more interesting: how one well-established drug design concept can be applied across multiple high-value patient needs. Relay is not just trying to create another PI3Kα inhibitor. Rather, they are looking to define a new paradigm around how PI3Kα inhibitors should be utilized by separating mutant target coverage from wild-type and off-isoform toxicity. This distinction matters because PI3Kα has never lacked biological interest. The issue was always the lack of therapeutic index. While there are clearly commercial implications to targeting PI3Kα (as evidenced by the approval and late-stage development of competing products), tolerability constraints prevented widespread use. I believe zovegalisib's developing data package represents an important milestone because it provides evidence that Relay may improve the utilization of PI3Kα inhibition by moving it from a treatment option with limitations to a treatment architecture available for long-term use across multiple indications, including second-line breast cancer, first-line breast cancer, and PIK3CA-driven vascular anomalies. Latest Financials To start, Relay is still a biotech in the clinical stage, and therefore the income statement does not reflect an operational business apart from license revenue; the company 's revenue for Q1 2026 , for example, totaled $3.0 million vs. $7.7 million in Q1 2025. R&D expenditures were lower this year at $70.6M compared to last year at $73.8M; G&A was also lower this year (down to $11.0M) from last year ($18.7M). Net loss decreased slightly to $73.3M, or $0.41/share, vs. a net loss of $77.1M, or $0.46/share, in the comparable period of the previous year. In contrast to the income statement, which reflects the company's losses, the balance sheet...
Posts from this author will be added to your daily email digest and your homepage feed. More than 47,000 Samsung Electronics workers are gearing up for an 18-day strike after bonus payment negotiations between the company and its union collapsed. The strike is set to start on Thursday, and will be limited to Samsung’s domestic chipmaking plants, raising concerns around the already constrained prod...
Posts from this author will be added to your daily email digest and your homepage feed. More than 47,000 Samsung Electronics workers are gearing up for an 18-day strike after bonus payment negotiations between the company and its union collapsed. The strike is set to start on Thursday, and will be limited to Samsung’s domestic chipmaking plants, raising concerns around the already constrained production of memory chips amid the ongoing shortage. While the union had agreed to mediation proposed by South Korea’s National Labor Relations Commission (the details of which have not been made public), management at Samsung Electronics rejected the deal without explanation, Nikkei Asia reports. As part of its demands, the Samsung union is seeking performance bonuses equivalent to 15 percent of the company’s operating profit, and the removal of a cap on bonuses of 50 percent of annual wages. The negotiations collapse comes during a time of record Samsung profits, having established itself as the world’s largest producer of memory chips. Both Samsung and the workers union had been urged by South Korean government officials to reach an agreement in the days leading up to the strike, with Prime Minister Kim Min-seok having reportedly warned that the government may step in and prevent the strike from going ahead. South Korean law permits an “emergency adjustment” to be invoked when disputes may harm the economy or daily life. Samsung is South Korea’s largest company, responsible for about 23 percent of the country’s exports and 26 percent of its total market capitalization, according to CNBC.
Securian Asset Management Inc. trimmed its holdings in Meta Platforms, Inc. (NASDAQ:META - Free Report) by 43.5% in the 4th quarter, according to the company in its most recent filing with the Securities and Exchange Commission (SEC). The institutional investor owned 59,221 shares of the social networking company's stock after selling 45,528 shares during the quarter. Meta Platforms comprises abou...
Securian Asset Management Inc. trimmed its holdings in Meta Platforms, Inc. (NASDAQ:META - Free Report) by 43.5% in the 4th quarter, according to the company in its most recent filing with the Securities and Exchange Commission (SEC). The institutional investor owned 59,221 shares of the social networking company's stock after selling 45,528 shares during the quarter. Meta Platforms comprises about 1.5% of Securian Asset Management Inc.'s investment portfolio, making the stock its 15th biggest holding. Securian Asset Management Inc.'s holdings in Meta Platforms were worth $39,091,000 at the end of the most recent quarter. Other institutional investors also recently modified their holdings of the company. Westchester Capital Management Inc. bought a new position in shares of Meta Platforms in the 3rd quarter worth about $26,000. Strategic Wealth Advisors LLC bought a new position in shares of Meta Platforms in the 4th quarter worth about $29,000. Key Capital Management INC bought a new position in shares of Meta Platforms in the 4th quarter worth about $48,000. Fairway Wealth LLC increased its stake in shares of Meta Platforms by 36.8% in the 4th quarter. Fairway Wealth LLC now owns 78 shares of the social networking company's stock worth $51,000 after acquiring an additional 21 shares in the last quarter. Finally, Merrithew & Thorsten Inc bought a new position in shares of Meta Platforms in the 4th quarter worth about $52,000. 79.91% of the stock is currently owned by institutional investors. Get Meta Platforms alerts: Sign Up Meta Platforms Stock Performance Shares of META stock opened at $602.61 on Wednesday. The company has a quick ratio of 2.35, a current ratio of 2.35 and a debt-to-equity ratio of 0.24. The firm has a market capitalization of $1.52 trillion, a PE ratio of 21.91, a P/E/G ratio of 1.07 and a beta of 1.25. The company has a 50 day moving average price of $620.35 and a 200-day moving average price of $637.91. Meta Platforms, Inc. has a 52 week low ...
Montana could soon ease restrictions on mining precious metals Restrictions on mining for precious metals like gold in Montana that were put in place 30 years ago could soon be relaxed as the mining industry makes a comeback in the U.S. News Montana could soon ease restrictions on mining precious metals Montana could soon ease restrictions on mining precious metals Audio will be available later to...
Montana could soon ease restrictions on mining precious metals Restrictions on mining for precious metals like gold in Montana that were put in place 30 years ago could soon be relaxed as the mining industry makes a comeback in the U.S. News Montana could soon ease restrictions on mining precious metals Montana could soon ease restrictions on mining precious metals Audio will be available later today. Restrictions on mining for precious metals like gold in Montana that were put in place 30 years ago could soon be relaxed as the mining industry makes a comeback in the U.S. Sponsor Message Sponsor Message
This year's list of endangered historic places focuses on equality and erasure toggle caption Whitney Browne, National Parks Conservation Association/National Trust for Historic Preservation Every year since 1988, the National Trust for Historic Preservation has released a list of the 11 most endangered historic sites in the country. It shines a light on significant places that have, in most cases...
This year's list of endangered historic places focuses on equality and erasure toggle caption Whitney Browne, National Parks Conservation Association/National Trust for Historic Preservation Every year since 1988, the National Trust for Historic Preservation has released a list of the 11 most endangered historic sites in the country. It shines a light on significant places that have, in most cases, fallen into neglect and disrepair but also some that are threatened by development, environmental or political factors. This year's list, released Wednesday, has a theme — a first — commemorating the 250th anniversary of the signing of the Declaration of Independence. "We chose to focus this year on sites important to the idea that all people are created equal," said Carol Quillen, the organization's president. "Over time, brave people have fought for equality before the law, equal opportunity, freedom of speech, due process, birthright citizenship. We wanted sites where those things happened." Sponsor Message As it happens, the National Trust is in the midst of a lawsuit against President Trump's administration over the addition of a massive ballroom to the White House. While this president's current home is not on the list, several historic sites overseen by the National Park Service that have been subject to controversy and legal challenges over changes made by the Trump administration are included. One such spot is New York City's Stonewall National Monument, which marks a milestone for LGBTQ rights. It saw the temporary removal of its Pride flag earlier this year. "The 11 most endangered list historically has picked sites of historical significance and deep meaning that are somehow at risk of being lost," Quillen said. "One of the ways that you can lose a site is through erasure, [when] what happened there is gradually forgotten or intentionally erased. And so that's a form of a threat to preservation that we're also interested in protesting." Each site featured on t...
Photo: IC Photo Chinese insurers kept buying stocks in the first quarter even as equity markets fell, highlighting the tension between state-mandated investment targets and solvency constraints. Stock holdings rose to 3.84 trillion yuan ($563 billion) at the end of March, up 102.4 billion yuan from the end of last year, according to data from the National Financial Regulatory Administration.
Photo: IC Photo Chinese insurers kept buying stocks in the first quarter even as equity markets fell, highlighting the tension between state-mandated investment targets and solvency constraints. Stock holdings rose to 3.84 trillion yuan ($563 billion) at the end of March, up 102.4 billion yuan from the end of last year, according to data from the National Financial Regulatory Administration.
Quantum computing hasn't hit the mainstream yet, but it's coming. Several companies are excited about the prospects of quantum computing and how it can transform how we do business. McKinsey & Company estimates that the quantum computing market could be worth up to $72 billion annually by 2035. That's a major market opportunity to capture. There are several competitors in this space, but I think t...
Quantum computing hasn't hit the mainstream yet, but it's coming. Several companies are excited about the prospects of quantum computing and how it can transform how we do business. McKinsey & Company estimates that the quantum computing market could be worth up to $72 billion annually by 2035. That's a major market opportunity to capture. There are several competitors in this space, but I think three stocks are primed to do well. If you're looking to get started investing in quantum computing, I think these three make for an excellent core to build a section of your portfolio around. IonQ The biggest problem with quantum computing right now is inaccuracy. Quantum computers use particles to perform computations, and measuring what's happening at the atomic level is difficult in the presence of significant background noise. So inaccuracies can easily enter a calculation. Every company in the quantum computing space is trying to solve this problem, but nobody has technology as accurate as IonQ (IONQ 1.76%). While most companies struggle to reach 99.9% accuracy, IonQ has already achieved 99.99%. Expand NYSE : IONQ IonQ Today's Change ( -1.76 %) $ -0.87 Current Price $ 48.44 Key Data Points Market Cap $18B Day's Range $ 45.51 - $ 49.44 52wk Range $ 25.89 - $ 84.64 Volume 175K Avg Vol 28M Gross Margin -2879.52 % As computing systems get larger, errors can compound. As a result, many available quantum computing devices are relatively small and cannot handle large workloads. However, IonQ is building a 256-qubit quantum computer using the same technology that enabled 99.99% accuracy. If this computer is successful, it puts IonQ on the fast track to becoming one of the top quantum computing investments. Alphabet Alphabet (GOOG 2.09%) (GOOGL 2.34%) is one of the legacy tech companies competing in quantum computing, and it has announced several breakthroughs. Alphabet is self-funding its quantum research, unlike others that must raise capital from the public markets. If it ca...
Key Points IonQ's leading computing technology gives it a major head start. Alphabet is a top player in the quantum industry. Nvidia is tying traditional and quantum computing methods together. 10 stocks we like better than IonQ › Quantum computing hasn't hit the mainstream yet, but it's coming. Several companies are excited about the prospects of quantum computing and how it can transform how we ...
Key Points IonQ's leading computing technology gives it a major head start. Alphabet is a top player in the quantum industry. Nvidia is tying traditional and quantum computing methods together. 10 stocks we like better than IonQ › Quantum computing hasn't hit the mainstream yet, but it's coming. Several companies are excited about the prospects of quantum computing and how it can transform how we do business. McKinsey & Company estimates that the quantum computing market could be worth up to $72 billion annually by 2035. That's a major market opportunity to capture. There are several competitors in this space, but I think three stocks are primed to do well. If you're looking to get started investing in quantum computing, I think these three make for an excellent core to build a section of your portfolio around. Will AI create the world's first trillionaire? Our team just released a report on the one little-known company, called an "Indispensable Monopoly" providing the critical technology Nvidia and Intel both need. Continue » IonQ The biggest problem with quantum computing right now is inaccuracy. Quantum computers use particles to perform computations, and measuring what's happening at the atomic level is difficult in the presence of significant background noise. So inaccuracies can easily enter a calculation. Every company in the quantum computing space is trying to solve this problem, but nobody has technology as accurate as IonQ (NYSE: IONQ). While most companies struggle to reach 99.9% accuracy, IonQ has already achieved 99.99%. As computing systems get larger, errors can compound. As a result, many available quantum computing devices are relatively small and cannot handle large workloads. However, IonQ is building a 256-qubit quantum computer using the same technology that enabled 99.99% accuracy. If this computer is successful, it puts IonQ on the fast track to becoming one of the top quantum computing investments. Alphabet Alphabet (NASDAQ: GOOG) (NASDAQ: G...
Ethereum (ETH +0.00%) may be down 55% from its 2025 all-time high, but that's not stopping top Wall Street strategist Tom Lee from talking up its future prospects. As he sees it, Ethereum is simply in a five-year consolidation phase. In fact, Ethereum could be ready to skyrocket in value. According to Lee, the future upside potential of Ethereum could be as high as $62,000. That's a head-spinning ...
Ethereum (ETH +0.00%) may be down 55% from its 2025 all-time high, but that's not stopping top Wall Street strategist Tom Lee from talking up its future prospects. As he sees it, Ethereum is simply in a five-year consolidation phase. In fact, Ethereum could be ready to skyrocket in value. According to Lee, the future upside potential of Ethereum could be as high as $62,000. That's a head-spinning 2,600% gain from today's price of just $2,300. So is he right? Key catalysts for Ethereum Obviously, a lot needs to go right for this to happen. For example, Ethereum must continue to maintain its dominant lead in decentralized finance (DeFi), especially in real-world asset tokenization. Several top consulting firms have already heralded asset tokenization as a potential multitrillion-dollar financial catalyst. But Lee goes one step further, encouraging others to view it as a potential $300 trillion opportunity. What happens, for example, if all the assets of the traditional financial world -- from stocks and bonds to real estate and private equity -- suddenly go on chain? Many of those new tokenized assets would presumably move to the Ethereum blockchain, creating a fantastic new growth opportunity. Lee refers to this as a "1971 moment" for Ethereum. In other words, Wall Street's sudden embrace of asset tokenization could be as big as the moment the world's financial system officially went off the gold standard in 1971. Another key factor involves Bitcoin (BTC +0.55%), the world's largest cryptocurrency. Historically, Bitcoin and Ethereum have marched together in lockstep. As Bitcoin marches higher, so does Ethereum (and vice versa). So if Bitcoin goes on another of its amazing runs, so will Ethereum. Ethereum / Bitcoin chart by TradingView From there, it's just math. Lee uses a simple ratio comparing the price of Ethereum and Bitcoin over time to estimate how much higher Ethereum might be able to go. Here's a quick look at the ETH/BTC ratio over time. Currently at 0.02, t...
The Philippine Supreme Court refused on Wednesday to block the arrest of a fugitive senator wanted by the International Criminal Court over his role in the nation’s deadly drug war. The interim ruling clears the way for the potential arrest of Senator Ronald Dela Rosa, the former national police chief who was the main enforcer of ex-president Rodrigo Duterte ’s crackdown. “The Supreme Court, in a ...
The Philippine Supreme Court refused on Wednesday to block the arrest of a fugitive senator wanted by the International Criminal Court over his role in the nation’s deadly drug war. The interim ruling clears the way for the potential arrest of Senator Ronald Dela Rosa, the former national police chief who was the main enforcer of ex-president Rodrigo Duterte ’s crackdown. “The Supreme Court, in a vote of 9-5-1, denied the prayer for a temporary restraining order and/or status quo ante order filed by Senator Ronald ‘Bato’ M. Dela Rosa,” a court statement said. Advertisement The ICC last week unsealed an arrest warrant against Dela Rosa, accused along with Duterte and other “co-perpetrators” of the crime against humanity of murder. Philippine Senator Ronald dela Rosa takes a phone call during a session at the Senate on Wednesday. Photo: Reuters Government agents tried to arrest Dela Rosa on the same day, but the pro-Duterte senate leadership foiled the attempt and gave him sanctuary. Advertisement Dela Rosa later left the senate for an unknown location following a shooting incident between government agents and senate security personnel on Wednesday that sent senators scurrying for cover in their offices.
Warren Buffett once said that his "favorite holding period is forever." His successor, Greg Abel, might seem to have a much shorter preferred holding period, based on Berkshire Hathaway's (BRKA 1.29%) (BRKB 1.62%) investment activity in the first quarter of 2026. With Abel at the helm, Berkshire completely exited a whopping 16 positions in Q1. Such a flurry of selling was practically unheard of du...
Warren Buffett once said that his "favorite holding period is forever." His successor, Greg Abel, might seem to have a much shorter preferred holding period, based on Berkshire Hathaway's (BRKA 1.29%) (BRKB 1.62%) investment activity in the first quarter of 2026. With Abel at the helm, Berkshire completely exited a whopping 16 positions in Q1. Such a flurry of selling was practically unheard of during Buffett's tenure as CEO. And two of the stocks that Abel dumped were especially big surprises. Berkshire's not-so-sweet 16 Liberty is in shorter supply in Berkshire's portfolio after Abel's Q1 moves. He sold all of Berkshire's stakes in Liberty Latin America Class A (LILA +3.39%), Liberty Latin America Class C (LILAK +3.46%), and Liberty Media's Formula One Group Series C (FWONK 1.11%) tracking stock. Berkshire also exited its position in Atlanta Braves Holdings (BATRK 1.21%), which was previously a Liberty Media tracking stock. Abel ditched several financial stocks. Berkshire's new CEO authorized the full sale of risk, retirement, and health solutions provider Aon (AON 0.89%). Credit card processing giants Mastercard (MA 1.28%) and Visa (V 0.82%) are also gone from the conglomerate's portfolio. A couple of food and beverage stocks were among the positions Berkshire exited in Q1. British alcoholic beverage maker Diageo (DEO +0.61%) has been part of the portfolio since the first quarter of 2023. Domino's Pizza (DPZ +1.54%) was an even shorter-lived position, with Berkshire initiating a new position in the third quarter of 2024. Berkshire had not owned several other stocks that Abel dumped in Q1 for very long. The conglomerate first purchased Heico (HEIA +0.00%) and Pool Corp. (POOL 1.57%) in 2024. It initiated positions in Allegion (ALLE 1.80%), Lamar Advertising (LAMR +1.30%), and UnitedHealth Group (UNH 0.48%) in 2025. However, not all of the positions exited last quarter were relatively recent purchases. Charter Communications (CHTR +0.91%) had been in Berkshire's po...