Dr. David Fajgenbaum, one of the founders of Every Cure, a nonprofit focused on drug repurposing. Courtesy of Every Cure A version of this story first appeared in the CNBC Cures newsletter. Click here to sign up. There are over 10,000 rare diseases — 95% of which don't have a cure. It can cost billions of dollars and take more than a decade to develop a new treatment. Because patient populations i...
Dr. David Fajgenbaum, one of the founders of Every Cure, a nonprofit focused on drug repurposing. Courtesy of Every Cure A version of this story first appeared in the CNBC Cures newsletter. Click here to sign up. There are over 10,000 rare diseases — 95% of which don't have a cure. It can cost billions of dollars and take more than a decade to develop a new treatment. Because patient populations in the rare disease space can sometimes only consist of a few thousand — or even a few dozen people — drug companies have been hesitant to invest that kind of time and capital developing a drug that's unlikely to turn a profit. Drug repurposing flips that model on its head. Repurposing looks for new ways to use existing drugs to treat diseases that they weren't originally designed for. And now there are groups that are using AI to make that process more efficient. When Dr. David Fajgenbaum and his colleagues were looking to launch Every Cure, a non-profit focused on drug repurposing, they had a big decision to make. "If you want to repurpose drugs, there are two ways you can go. One is you can say, we are going to open up our shop and let patients and disease groups come to us and say, 'Hey, will you find a drug for my disease?'" Fajgenbaum said. "Or you take another approach ... using AI to find basically the lowest-hanging fruit across all drugs and all diseases." Fajgenbaum and his co-founders chose the second option. Every Cure doesn't search for a specific treatment for a specific disease. Instead, it looks to see if there are any existing drugs that can help any existing disease. The group looks for drug-disease matches, and then connects with the patients that can benefit. This marks a big departure from the way that rare disease treatments have traditionally been developed. "The way that research has always been done, if you want someone to do your research, you go to them, you give them money," Fajgenbaum said. "So people come to us, and they're like, we want you to...
Treasuries fell, lifting benchmark yields to the highest levels this year, as oil prices resumed the advance unleashed by the US war on Iran, which is entering its fifth week. While the declines were at least pared, and short-maturity tenors erased their losses, the market’s initial response to oil’s rebound from a late-Thursday slump was a rise in two- to 10-year yields to the highest levels sinc...
Treasuries fell, lifting benchmark yields to the highest levels this year, as oil prices resumed the advance unleashed by the US war on Iran, which is entering its fifth week. While the declines were at least pared, and short-maturity tenors erased their losses, the market’s initial response to oil’s rebound from a late-Thursday slump was a rise in two- to 10-year yields to the highest levels since mid-2025. The 10-year rose as much as seven basis points to 4.48%, the highest since July, before retreating to about 4.44%, while the 30-year bond’s yield came within a basis point of 5%, also last seen in July. Treasury yields have been rising with oil prices since the US attacked Iran on Feb. 28, disrupting supply from the region. Yields and oil prices briefly slumped late Thursday after US President Donald Trump extended a 10-day pause on strikes against Iranian energy sites, even as he cast doubt on the possibility of reaching a peace deal. “Yields are moving higher along with oil as a 10-day delay isn’t good news, said John Briggs , head of US rates strategy at Natixis. “It’s another 10 days that the Strait of Hormuz is shut.” Higher yields reflect the potential for the related increase in US retail gasoline prices to show up in broad measures of consumer inflation, deterring the Federal Reserve from delivering interest-rate cuts that were widely expected before the outbreak of hostilities. As long as the strait remains closed, investors will fear “inflation and a 2022-style response from central banks.” Briggs said. The oil shock from Russia’s full-scale invasion of Ukraine in 2022 contributed to an post-pandemic inflation surge that led the Fed to raise rates by more than five percentage points by mid-2023. Market-based inflation expectations for the coming year, though off last week’s highs, have surged past 3% from about 2.2% at the start of the year. Swap contracts whose rates represent expectations for future Fed rate decisions no longer signal any chance of a...
Renders of the Razr Ultra 2026 show a slightly thicker phone than last year’s model. | Image: XpertPick/OnLeaks While most flagship phones have been steadily getting slimmer over recent years, the upcoming 2026 version of the Motorola Razr Ultra could end up being a bit chunkier than its predecessor. Leaked measurements of the phone shared by XpertPick and OnLeaks on Thursday show that it will be ...
Renders of the Razr Ultra 2026 show a slightly thicker phone than last year’s model. | Image: XpertPick/OnLeaks While most flagship phones have been steadily getting slimmer over recent years, the upcoming 2026 version of the Motorola Razr Ultra could end up being a bit chunkier than its predecessor. Leaked measurements of the phone shared by XpertPick and OnLeaks on Thursday show that it will be slightly thicker than the 2025 version, about 0.1mm more when folded and 0.6mm more when unfolded. The full dimensions of the Ultra 2026, according to the leaked specs, are 171.3 x 74.1 x 7.8mm when unfolded and 88.0 x 74.1 x 15.8mm when folded. With the camera bump, the Ultra 2026 could be up to 9.6mm unfolded or 17.63mm folded. A little extra bulk could … Read the full story at The Verge.
SeregaSibTravel/iStock Editorial via Getty Images Shares of Carnival Corp. ( CCL ) are underwater at Friday’s open as record fiscal first-quarter results that included record bookings for the quarter and a long-term goal of 50% EPS growth were overshadowed by the company’s expectation that higher fuel prices will weigh on its full-year results. “Given the recent spike and volatility in fuel prices...
SeregaSibTravel/iStock Editorial via Getty Images Shares of Carnival Corp. ( CCL ) are underwater at Friday’s open as record fiscal first-quarter results that included record bookings for the quarter and a long-term goal of 50% EPS growth were overshadowed by the company’s expectation that higher fuel prices will weigh on its full-year results. “Given the recent spike and volatility in fuel prices, we believe it is reasonable to forecast fuel based on the purchased price for the month of March and early April,” the company said. The company now expects to earn an adjusted profit of $2.21 per share, down from its earlier guidance of $2.48 per share and less than $2.36 estimates. Adjusted EBITDA is seen at $7.2B versus $7.6B previously. Excluding fuel, overall costs are seen lower this year as the company guided adjusted cruise costs per available lower berth days (ALBD) up 3.1% year-over-year (constant currency) versus a prior outlook of up 3.25%. While the company will consume the same amount of fuel this year, the cost swelled to $718 per metric ton compared to an earlier estimate of $524, raising its fuel expense to $2.15B in FY26 from an earlier estimate of $1.63B. For the current fiscal quarter, Carnival ( CCL ) expects an adjusted profit of $0.34 per share, less than $0.39 per share estimates. For the reported quarter, however, Carnival beat both profit and sales expectations with increases of 54% and 6.2%, respectively, year-over-year. Bookings for 2026 are already surpassing prior records, up by double digits “strengthening the company’s record booked position at historically high prices.” Carnival ( CCL ) also announced PROPEL, a set of long-term targets designed to reflect continued earnings growth momentum, outsized shareholder distribution, and higher returns to be achieved by 2029. PROPEL goals include a 16%+ return on invested capital, 50% adjusted EPS growth from 2025, and 40%+ distributions to shareholders. Finally, the board approved an additional $2...
Klaus Vedfelt/DigitalVision via Getty Images Investment thesis My thesis on investing in Atlassian ( TEAM ) has evolved since the last article I wrote. Unfortunately, I've never had an opportunity to modify my opinion. I went from " Strong Buy " to " Hold " primarily based on the fact that Atlassian is no longer a "trust your instincts" kind of stock where you can buy it simply because it appears ...
Klaus Vedfelt/DigitalVision via Getty Images Investment thesis My thesis on investing in Atlassian ( TEAM ) has evolved since the last article I wrote. Unfortunately, I've never had an opportunity to modify my opinion. I went from " Strong Buy " to " Hold " primarily based on the fact that Atlassian is no longer a "trust your instincts" kind of stock where you can buy it simply because it appears cheap. While the decline in price has been extreme, upon further examination the business looks much more solid than the chart suggests. The revenue growth continues to be healthy, the advancement of their cloud continues to move forward rapidly, they were able to mitigate the contracted demand reasonably effectively, and they have developed a unique ecosystem of products around Jira, Confluence, and Jira Service Management which makes it increasingly difficult for competitors to create comparable products that fit into their customers' workflows. The most recent quarter was not poor by any stretch of the imagination, rather it illustrated a company that continues to execute. That said, I don't believe this is the right context to aggressively increase a position. The issue now centers on whether Atlassian will be able to protect their per-seat economics, continue to enjoy pricing power, and prove that artificial intelligence (AI) will serve as a means of creating new sources of monetization and will not create additional downward pressures on multiples and growth quality. Those risks are no longer speculative. Indeed, it is exactly those same factors which would constitute a " bearish " or " negative " case for this particular stock (the increased competition, potentially fewer work stations as a result of improved productivity through AI, customer resistance to higher prices, and the operational risks that arise from recent corporate restructuring initiatives). I continue to hold an amount of stock in Atlassian as part of my portfolio. I have a strong commitment to retain...
Columbia Threadneedle Investments, an investment management company, released its fourth-quarter 2025 investor letter for “Columbia Global Technology Growth Fund”. A copy of the letter can be downloaded here. Markets advanced modestly higher in Q4 2025, with the S&P 500 returning 2.66%, the Nasdaq 100 gaining 2.47%, and the Dow Jones Industrial Average leading with a […]
Columbia Threadneedle Investments, an investment management company, released its fourth-quarter 2025 investor letter for “Columbia Global Technology Growth Fund”. A copy of the letter can be downloaded here. Markets advanced modestly higher in Q4 2025, with the S&P 500 returning 2.66%, the Nasdaq 100 gaining 2.47%, and the Dow Jones Industrial Average leading with a […]
CAMBRIDGE, UK / ACCESS Newswire / March 27, 2026 /Theia Insights, a Cambridge-based deep-tech company whose technology is used by global index providers, asset managers, hedge funds and banks, has raised $8 million in Series A funding. The round was ...
CAMBRIDGE, UK / ACCESS Newswire / March 27, 2026 /Theia Insights, a Cambridge-based deep-tech company whose technology is used by global index providers, asset managers, hedge funds and banks, has raised $8 million in Series A funding. The round was ...
More and more Silicon Valley CEOs are blaming job losses on AI. But according to OpenAI CEO Sam Altman, these big layoffs have less to do with technology and more to do with traditional business fundamentals.
More and more Silicon Valley CEOs are blaming job losses on AI. But according to OpenAI CEO Sam Altman, these big layoffs have less to do with technology and more to do with traditional business fundamentals.