Earnings Call Insights: Karyopharm Therapeutics (KPTI) Q1 2026 Management View "Karyopharm continues to execute through an important period for the company with recent and upcoming milestones that we believe can unlock meaningful growth opportunities and shape our next phase," said (President, CEO & Director Richard Paulson), adding that since the prior call the company reported "top line results ...
Earnings Call Insights: Karyopharm Therapeutics (KPTI) Q1 2026 Management View "Karyopharm continues to execute through an important period for the company with recent and upcoming milestones that we believe can unlock meaningful growth opportunities and shape our next phase," said (President, CEO & Director Richard Paulson), adding that since the prior call the company reported "top line results from our Phase III SENTRY trial in myelofibrosis," "complet[ed] enrollment in XPORT-EC-042 in endometrial cancer," and "strengthen[ed] our balance sheet through the financing completed in Q1." On SENTRY, (EVP, Chief Medical Officer & Head of Research Reshma Rangwala) said the trial met the co-primary endpoint for spleen response: "The co-primary endpoint of SVR35 at week 24 was 50% for the combination compared to 28% for ruxolitinib alone, corresponding to a statistically significant p-value of less than 0.0001." She also highlighted OS and potential disease modification signals: "At the time of the top line data, the overall survival hazard ratio was 0.43 with a nominal p-value of 0.0222" and "the greater proportion of patients on the combination arm at 32% who experienced a variant allele frequency reduction of at least 20% may be indicative of an underlying effect on the disease biology." (EVP, Chief Commercial Officer & Head of Business Development Sohanya Cheng) framed Q1 XPOVIO dynamics as pricing/returns-driven, while citing competitive pressure on demand: "We delivered strong net product revenue growth this quarter, driven primarily by favorable gross to net dynamics," while "underlying demand for XPOVIO was lower compared to the first quarter of 2025, reflecting the impact of new competitive entrants." (EVP, CFO & Treasurer Lori Macomber) detailed the quarter’s revenue and cost profile: "Total revenue for the first quarter was $35.1 million compared to $30 million in the prior year period" and "U.S. XPOVIO net product revenue was $29.2 million compared to $21.1 mil...
Earnings Call Insights: Intuitive Machines (LUNR) Q1 2026 Management View CEO Stephen Altemus opened by saying, "Intuitive Machines continues to execute, grow and win new business at a record pace," and highlighted that "Our acquisition of Lanteris has been immediately accretive with the combined entity value already bearing fruit." CEO Altemus said the U.S. Space Force Space Systems Command selec...
Earnings Call Insights: Intuitive Machines (LUNR) Q1 2026 Management View CEO Stephen Altemus opened by saying, "Intuitive Machines continues to execute, grow and win new business at a record pace," and highlighted that "Our acquisition of Lanteris has been immediately accretive with the combined entity value already bearing fruit." CEO Altemus said the U.S. Space Force Space Systems Command selected the company for "the Andromeda IDIQ contract" and described it as "a 10-year vehicle with an anticipated ceiling value of $6.24 billion," adding, "This award marks our first major selection as a combined company following the acquisition of Lanteris." CEO Altemus announced, "Today, we are also pleased to announce the signing of a definitive agreement for the purchase of Goonhilly Earth Station and its subsidiary in the U.S. COMSAT," framing it as part of building capability to "manufacture spacecraft, connect space-to-ground networks and operate space infrastructure across multiple domains for a diversified customer base." CEO Altemus said the company "started 2026 with the strongest quarter in our company's history" and reported "record revenue of $187 million," "more than $30 million of gross margin," "positive adjusted EBITDA," "a record backlog of $1.1 billion," and "more than $400 million in new bookings this quarter." CFO Peter McGrath said, "Q1 marked an inflection point for the company financially," and added, "We delivered record revenue, positive adjusted EBITDA and record backlog while closing on the Lanteris acquisition and continuing to invest in future infrastructure capabilities." Outlook CFO McGrath said, "We are maintaining our revenue outlook range between $900 million to $1 billion," and added, "a significant portion of our expected 2026 revenue is already supported by contract backlog giving us strong visibility into our outlook as we await significant award decisions in the coming weeks." CFO McGrath reiterated profitability expectations, saying, "O...
派息方案与关键日期 德雅致主动型加拿大债券净零排放路径ETF(Desjardins RI Active Cdn Bd NetZero Emis Pthwy ETF)宣布，将进行月度现金分配，每股派息0.0496加元。本次派息的股权登记日为2026年5月22日，除息日为同一天，派息日为2026年5月29日。 以当前股价估算，该ETF的前瞻年化收益率约为3.20%。 净零排放路径投资策略 该ETF的全...
派息方案与关键日期 德雅致主动型加拿大债券净零排放路径ETF(Desjardins RI Active Cdn Bd NetZero Emis Pthwy ETF)宣布，将进行月度现金分配，每股派息0.0496加元。本次派息的股权登记日为2026年5月22日，除息日为同一天，派息日为2026年5月29日。 以当前股价估算，该ETF的前瞻年化收益率约为3.20%。 净零排放路径投资策略 该ETF的全称为Desjardins RI Active Canadian Bond - Net-Zero Emissions Pathway ETF，在加拿大多伦多证券交易所上市，交易代码为DRCU。 基金的投资目标是在获取收入和长期资本增值的同时，逐步降低投资组合的融资排放，致力于到2030年将融资排放量较2020年减少50%，并最终在2050年实现净零排放。截至2024年12月31日，该ETF已实现融资排放量较2020年减少61.1%，进度远超阶段性目标。 投资组合与费用概况 该基金主要投资于加拿大政府、政府机构及企业发行的债务证券，并对发行人的环境、社会及治理表现进行评估。投资组合中，政府债券占比约54.8%，公司债券占比约35.6%。 基金的管理费率为0.35%，资产规模约4480万加元。 责任编辑：张俊 SF065
Royal Lyceum, Edinburgh Dawn Steele stars in Ron Ferguson’s warm-hearted tale of a town whose fortunes are tied to those of its coal mine and local team Black diamonds are what they used to dig up from the Fife coalfields. The Blue Brazil is the unlikely nickname of Cowdenbeath football club. Together, in the 1993 book by Ron Ferguson , they represent the bittersweet hopes of a downtrodden town: t...
Royal Lyceum, Edinburgh Dawn Steele stars in Ron Ferguson’s warm-hearted tale of a town whose fortunes are tied to those of its coal mine and local team Black diamonds are what they used to dig up from the Fife coalfields. The Blue Brazil is the unlikely nickname of Cowdenbeath football club. Together, in the 1993 book by Ron Ferguson , they represent the bittersweet hopes of a downtrodden town: the coal that brought work, fatal accidents and unemployment; the team that brought moments of joy and a litany of loss. You would call it a triumph of the underdog, except this team never triumphs. “Some things are more important than winning,” is the catchphrase of the ex-miner and diehard Cowdenbeath fan (Barrie Hunter) who haunts this warm-hearted adaptation by Gary McNair, first aired as an audio drama in 2021 . More important, the playwright would argue, is a sense of community, of shared experience, of learning not to be defeated by pit closures, job losses, relegation and death. It is about “how to lose and keep going with hope”. Continue reading...
Photographer recognised for Berlin exhibition that documented queer love, nationalism and subcultures Rene Matić, whose work unpicks modern British identity and has been described as “ the Wolfgang Tillmans of their generation ”, has won the Deutsche Börse Photography Foundation prize 2026. The Peterborough-born photographer was awarded the £30,000 prize, which is among the most prestigious art aw...
Photographer recognised for Berlin exhibition that documented queer love, nationalism and subcultures Rene Matić, whose work unpicks modern British identity and has been described as “ the Wolfgang Tillmans of their generation ”, has won the Deutsche Börse Photography Foundation prize 2026. The Peterborough-born photographer was awarded the £30,000 prize, which is among the most prestigious art awards in Europe, after being nominated alongside Jane Evelyn Atwood, Weronika Gęsicka and Amak Mahmoodian. Continue reading...
In this exclusive book extract, Rob Draper and Jonathan Northcroft reveal the remarkable process which led to Thomas Tuchel’s appointment as England manager In 2024, when the Football Association was tasked with finding Gareth Southgate’s successor, Mark Bullingham hired two external data companies who built a profile of what successful international managers looked like then tailored it to mesh w...
In this exclusive book extract, Rob Draper and Jonathan Northcroft reveal the remarkable process which led to Thomas Tuchel’s appointment as England manager In 2024, when the Football Association was tasked with finding Gareth Southgate’s successor, Mark Bullingham hired two external data companies who built a profile of what successful international managers looked like then tailored it to mesh with England’s player base. The top 50 coaches in the world were matched against the criteria and a shortlist emerged. “I joked with the team afterwards, because it came up with a list you and I could have come up with in the pub in 10 minutes,” Bullingham, the FA’s chief executive, says. Continue reading...
Zelenskyy's Former Right-Hand Man Yermak Arrested In $10.5 Million Money Laundering Scheme Ukraine’s High Anti-Corruption Court ordered the pre-trial detention of Andriy Yermak, the powerful former head of President Volodymyr Zelenskyy’s Office and once the country’s second-most influential figure, on money-laundering charges tied to a high-profile corruption scheme. The ruling marks a dramatic fa...
Zelenskyy's Former Right-Hand Man Yermak Arrested In $10.5 Million Money Laundering Scheme Ukraine’s High Anti-Corruption Court ordered the pre-trial detention of Andriy Yermak, the powerful former head of President Volodymyr Zelenskyy’s Office and once the country’s second-most influential figure, on money-laundering charges tied to a high-profile corruption scheme. The ruling marks a dramatic fall for Yermak, who served as Zelenskyy’s closest aide from 2020 until his resignation in late 2025 amid earlier raids. He was taken into custody directly from the courtroom following the decision. Charges and Allegations Ukraine’s National Anti-Corruption Bureau (NABU) and Specialized Anti-Corruption Prosecutor’s Office (SAPO) named Yermak a suspect on May 11 in a scheme involving the laundering of approximately 460 million hryvnias (about $10.5 million or €9-10 million). Prosecutors allege he participated in an organized criminal group that funneled illicit funds - originating from kickbacks at the state nuclear energy company Energoatom -through shell companies and fake contracts into the construction of a luxury residential complex (known as “Dynasty”) in the affluent village of Kozyn, south of Kyiv. The broader “Midas” investigation into Energoatom reportedly uncovered a pattern where contractors paid 10-15% kickbacks to officials to secure or maintain deals. Funds were allegedly laundered between 2021 and 2025 via elite real estate development. Yermak faces charges under Part 3 of Article 209 of Ukraine’s Criminal Code (legalization of criminally obtained proceeds). A conviction could carry up to 12 years in prison. After multi-day hearings, the High Anti-Corruption Court (HACC) imposed 60 days of pre-trial detention starting May 14, with an alternative of bail set at 140 million hryvnias (roughly $3.2 million ). Prosecutors had requested a higher bail of 180 million hryvnias (about $4 million). Yermak was remanded in custody immediately, though he could secure release...
Microsoft first started opening up access to Claude Code in December, inviting thousands of its own developers to use Anthropic's AI coding tool daily. It was part of an effort to get project managers, designers, and other employees to experiment with coding for the first time, and sources tell me that Claude Code has proved very popular inside Microsoft over the past six months. Perhaps a little ...
Microsoft first started opening up access to Claude Code in December, inviting thousands of its own developers to use Anthropic's AI coding tool daily. It was part of an effort to get project managers, designers, and other employees to experiment with coding for the first time, and sources tell me that Claude Code has proved very popular inside Microsoft over the past six months. Perhaps a little too popular, as Microsoft is now preparing to walk back its Claude Code push. I understand that Microsoft is planning to remove most of its Claude Code licenses and push many of its developers to use Copilot CLI instead. While Claude Code has been … Read the full story at The Verge.
Three of the first venture capital investors in Cerebras Systems Inc. are set to earn billions of dollars from their early bets on the chipmaker following its Wall Street debut on Thursday. Benchmark will own roughly 8.1% of the outstanding shares in Cerebras after the initial public offering, according to a securities filing. At the $185-per-share IPO price for Cerebras, that stake was worth abou...
Three of the first venture capital investors in Cerebras Systems Inc. are set to earn billions of dollars from their early bets on the chipmaker following its Wall Street debut on Thursday. Benchmark will own roughly 8.1% of the outstanding shares in Cerebras after the initial public offering, according to a securities filing. At the $185-per-share IPO price for Cerebras, that stake was worth about $3.2 billion. That marks a 12-fold return for Benchmark, which invested a total of $268 million in Cerebras across multiple funding rounds, according to the firm. Eclipse and Foundation Capital co-led the first funding round in Cerebras alongside Benchmark, when the startup was only valued at $60 million, including the investment. Eclipse’s 6.2% stake in the chipmaker was worth $2.5 billion at the IPO price, 17 times the $146.5 million it invested, according to the venture firm. Foundation’s 7% stake was worth $2.8 billion. (Fidelity, a later investor, has amassed the largest stake.) Shares of Cerebras jumped 89% to open at $350 each on Thursday. At that price, the value of Eclipse’s stake had climbed to $5.2 billion, not accounting for any shares sold in the IPO. Benchmark’s stake was worth about $6 billion and Foundation’s was worth roughly $5.3 billion. Cerebras, which competes with Nvidia Corp , made its long anticipated public market debut, seizing on investor appetite for all things artificial intelligence. The company’s IPO offers a rare and lucrative exit for venture firms as more startups stay private longer. Cerebras also has a long list of notable individual backers, including OpenAI’s Sam Altman and Greg Brockman, as well as Intel Chief Executive Officer Lip-Bu Tan. But few stand to benefit as much as Benchmark, which previously made successful bets on Uber Technologies Inc. and eBay Inc. When Benchmark first backed Cerebras in 2016, Nvidia was still valued in the billions and AI was far from top of mind to the general public. Cerebras also represented a depar...
AMD (NASDAQ:AMD) and Intel (NASDAQ:INTC) both reported Q1 fiscal 2026 results within two weeks of each other, and the contrast is striking. AMD posted $10.25 billion in revenue powered by AI accelerators, while Intel delivered $13.58 billion alongside a sprawling foundry rebuild. Two chipmakers, two very different bets on where compute is heading. Data Center ... AMD vs Intel: One Triples Free Cas...
AMD (NASDAQ:AMD) and Intel (NASDAQ:INTC) both reported Q1 fiscal 2026 results within two weeks of each other, and the contrast is striking. AMD posted $10.25 billion in revenue powered by AI accelerators, while Intel delivered $13.58 billion alongside a sprawling foundry rebuild. Two chipmakers, two very different bets on where compute is heading. Data Center ... AMD vs Intel: One Triples Free Cash Flow While Another Burns Billions on Foundry Ambitions
In January, Colorado lawmakers introduced a proposal to make operating systems collect users' ages and pass them to app developers. The bill, SB26-051 , had clearly been designed for commercial platforms like iOS and Android - one of numerous plans to age-gate the internet through users' devices. It was intended to provide information that would let developers disable age-inappropriate experiences...
In January, Colorado lawmakers introduced a proposal to make operating systems collect users' ages and pass them to app developers. The bill, SB26-051 , had clearly been designed for commercial platforms like iOS and Android - one of numerous plans to age-gate the internet through users' devices. It was intended to provide information that would let developers disable age-inappropriate experiences for kids. But as it made the rounds online, Linux laptop maker Carl Richell read the proposal with dismay. Carl Richell is the founder and CEO of Dever-based System76, which also develops the Pop!_OS Linux distribution. The law, he realized, would … Read the full story at The Verge.
Key PointsSiren initiated a new position by acquiring 1,505,374 shares of Veradermics; the estimated transaction value is $75.94 million based on quarterly average pricing.
Key PointsSiren initiated a new position by acquiring 1,505,374 shares of Veradermics; the estimated transaction value is $75.94 million based on quarterly average pricing.
jetcityimage To reduce its reliance on third-party lenders, Stellantis’ ( STLA ) application for deposit insurance has been approved by the Federal Deposit Insurance Corporation (FDIC), allowing the auto manufacturer to establish Stellantis Bank USA, a Utah-chartered industrial bank. The bank will provide auto financing primarily through the purchase of retail installment contracts from independen...
jetcityimage To reduce its reliance on third-party lenders, Stellantis’ ( STLA ) application for deposit insurance has been approved by the Federal Deposit Insurance Corporation (FDIC), allowing the auto manufacturer to establish Stellantis Bank USA, a Utah-chartered industrial bank. The bank will provide auto financing primarily through the purchase of retail installment contracts from independent Stellantis ( STLA ) dealers. Stellantis Bank USA is being established as an industrial loan company (ILC) and as such, the parent company is not subject to Federal Reserve oversight. The distinction did not sit well with the National Community Reinvestment Coalition, which opposed the FDIC approval, given the ILC charter creates a “dangerous mix of commerce and banking” in that regulators have little insight into the parent company’s operations despite being related to the banking operations. “Lower-cost deposits would increase the interdependence between its financing and manufacturing divisions, leading to correlated risks that undermine safety and soundness. Automobile manufacturing is a highly cyclical industry whose history demonstrates that it can lose money during a recession,” the NCRC wrote to the FDIC. Despite these risks, the FDIC believes Stellantis ( STLA ) satisfies the statutory factors necessary to operate a bank, including an adequate capital structure and “corporate powers that are consistent with the purposes of the Federal Deposit Insurance Act.” Under the terms of the approval, Stellantis Bank USA ( STLA ) will be required to maintain a minimum 15% tier 1 leverage ratio, and the parent company, Stellantis N.V., and two of its subsidiaries will be required to support the bank’s capital and liquidity positions. Stellantis ( STLA ) has twelve months from the time of the FDIC approval to establish Stellantis Bank USA. Currently, financing for new automobile loans is provided through Stellantis Financial Services through a partnership with Santander Consum...
一季度业绩：收入略超预期，利润指标承压 SBC Medical Group Holdings公布2026年第一季度财报。数据显示，公司一季度营收达4306万美元，同比下降9%，但略高于市场预期的4165万美元；GAAP每股收益为0.11美元，高于预期的0.09美元。净利润为1131万美元，同比下滑47%，净利润率收窄至26%；EBITDA为1839万美元，同比下降26%，EBITDA利润率为43%...
一季度业绩：收入略超预期，利润指标承压 SBC Medical Group Holdings公布2026年第一季度财报。数据显示，公司一季度营收达4306万美元，同比下降9%，但略高于市场预期的4165万美元；GAAP每股收益为0.11美元，高于预期的0.09美元。净利润为1131万美元，同比下滑47%，净利润率收窄至26%；EBITDA为1839万美元，同比下降26%，EBITDA利润率为43%。 公司首席执行官相川嘉之表示，收入下滑主要归因于2025年4月实施的特许经营费用结构调整。剔除该结构性变化，核心业务表现保持稳健。 费用结构影响逐步消退，运营基本面稳固 管理层在财报电话会议上强调，费用结构调整的同比影响预计将逐步消退，为后续利润率改善创造条件。运营指标显示基本面持续向好：特许经营网点增至284个，同比增加33个；过去12个月客户达676万人，同比增长10%；重复到访率达72%。 同期每股收益0.11美元，高于市场预期的0.10美元。 AI部署与并购驱动长期增长 SBC正通过AI技术部署与战略性并购两条路径推动利润率提升及全球扩张。公司持续推进美容皮肤科多品牌战略，拓展非美容医疗业务，并深耕海外市场运营基础。管理层透露，公司还将探索长寿医疗市场机遇，并通过AI进一步优化服务能力，目标是构建可持续增长的医疗健康平台。 责任编辑：张俊 SF065
Employment in the Brazilian oil industry has rebounded to the highest since the golden era of Petrobras ’s mega-projects in 2010. The buildout of offshore discoveries including Buzios has boosted investment and created a talent shortage in Latin America’s biggest oil-producing country, said Telmo Ghiorzi, head of trade group ABESPetro. Tens of billions of dollars in spending has allowed the sector...
Employment in the Brazilian oil industry has rebounded to the highest since the golden era of Petrobras ’s mega-projects in 2010. The buildout of offshore discoveries including Buzios has boosted investment and created a talent shortage in Latin America’s biggest oil-producing country, said Telmo Ghiorzi, head of trade group ABESPetro. Tens of billions of dollars in spending has allowed the sector to overcome setbacks from a decade ago that included a massive corruption scandal, an oil-price crash, and a prolonged halt in exploration licenses, he said. Employment levels are expected to stabilize for a few years before beginning to decline in the early 2030s after state-controlled Petroleo Brasileiro SA finishes current projects in the deepwater region known as the pre-salt. “If we don’t have discoveries, we won’t have jobs,” Ghiorzi said at a press conference on Thursday. “There are concerns that need to be addressed to maintain this level.” Oil has become Brazil’s single largest export in recent years, but Ghiorzi warned that the country is at risk of becoming an importer within a decade unless there is a pick up in exploration at offshore areas including the Equatorial Margin, which has suffered from licensing delays. If large discoveries are made, employment could rebound in the late 2030s and surpass current levels. Brazil’s offshore equipment industry could also supply projects in Suriname and Namibia in addition to Guyana, which is already sourcing equipment from Brazilian suppliers, he said.