Tiziana Life Sciences于5月19日公布了其鼻内给药foralumab在非活动性继发进展型多发性硬化症患者中的最新临床数据。结果显示，该疗法在长期治疗中表现出极佳的耐受性，并在残疾稳定和疲劳改善方面呈现积极趋势。 长期安全性数据积极 本次数据更新覆盖了2025年3月至2026年3月的随访期，共纳入14名na-SPMS患者。研究未发现新的安全性信号，鼻内给药foralumab在延长...
US President Donald Trump endorsed Texas Attorney General Ken Paxton in the state’s Republican Senate primary shortly after early voting began in an increasingly personal and expensive run-off against incumbent Senator John Cornyn. “Ken Paxton has my Complete and Total Endorsement to be the next United States Senator from the Great State of Texas – KEN PAXTON WILL NEVER LET YOU DOWN!,” Trump said ...
US President Donald Trump endorsed Texas Attorney General Ken Paxton in the state’s Republican Senate primary shortly after early voting began in an increasingly personal and expensive run-off against incumbent Senator John Cornyn. “Ken Paxton has my Complete and Total Endorsement to be the next United States Senator from the Great State of Texas – KEN PAXTON WILL NEVER LET YOU DOWN!,” Trump said in a social media post on Tuesday. The timing of the move came as a shock, with early voting already under way. It’s also likely to rankle many Republican leaders in Texas and on Capitol Hill who had backed Cornyn, a four-term senator once seen as a potential majority leader. Advertisement After trailing Paxton in the polls for much of last year, Cornyn rallied to lead the March 3 primary vote, garnering about 42 per cent while Paxton got almost 41 per cent. “It’s his decision,” a grim-faced Senate Majority Leader John Thune, a key Cornyn ally, said when asked of the endorsement. US Senator John Cornyn speaks to the media in Austin, Texas, in March. Photo: AP Trump’s endorsement is seen as critical in Texas, a state the president won by nearly 14 percentage points in 2024. Democrats, sensing opportunity as Trump’s approval ratings sag, are targeting the Lone Star state as part of an uphill battle to gain control of the US Senate.
Richard Drury/DigitalVision via Getty Images A2Z Q1 Recap A2Z Cust2Mate Solutions ( AZ ) filed quarterly documents on May 14th and issued an earnings press release on the morning of May 15th before it hosted the company's first-ever quarterly conference call. The Thursday release was good. There were a couple of problems with the Friday morning items. Revenue in the filing was fine at $3.3 million...
Richard Drury/DigitalVision via Getty Images A2Z Q1 Recap A2Z Cust2Mate Solutions ( AZ ) filed quarterly documents on May 14th and issued an earnings press release on the morning of May 15th before it hosted the company's first-ever quarterly conference call. The Thursday release was good. There were a couple of problems with the Friday morning items. Revenue in the filing was fine at $3.3 million, as was gross profit of $139 thousand. The company delivered 500 carts and finished the quarter with 2,500 carts in the field. Remember that this is a razor and blades business model. As such, I believe with a standard pricing scenario, they lose $500 or so upfront when they deliver a cart. They make up for that loss with high-margin SaaS fees and burgeoning retail media sales. Given how low the company is on the hockey stick, deliveries are a high percentage of total deployed units. That initial loss is a big percentage of the SaaS/retail media mix, so I'd expect a low gross margin. However, it's welcome as we want as many deliveries as we can get. The problems started when the company issued an earnings press release on Friday morning. It had the same revenue as the filing but a negative gross profit of $487k. Wait, what? That wasn't the only difference. There was also a bigger net income loss. They corrected it with a follow-up 10 am press release . Item Filing 6am PR 10am Pr Delta Revenue $3,317 $3,317 $3,317 0 COGS 3,178 3,804 3,178 626 Gross Profit 139 (487) 139 (626) R&D 2,930 2,619 2,930 (311) Sales & Mktg 2,194 2,194 2,194 0 SG&A 3,042 3,042 3,042 0 EBIT (8,027) (8,342) (8,027) (315) Fin'l Inc 160 160 160 Fin'l Exp (414) (422) (414) (7) Minority Int. (209) (210) (209) (1) Common Net Income (8,072) (8,394) (8,072) (322) Net Income for Period (8,281) (8,604) (8,281) (323) Click to enlarge So, the 6am release added over 600k of COGS and lowered R&D by about half that amount but resulted in about $300k more loss. The 10am release matched the filing. I honestly have no...
Some of the market's biggest long-term winners looked incredibly risky early on in their development. They were unprofitable. They burned cash aggressively. And many investors avoided them because they simply didn't look "safe." A great example of this is Amazon in its early days. That's what makes CoreWeave (CRWV 4.15%) such an interesting stock today. While the short answer to the headline quest...
Some of the market's biggest long-term winners looked incredibly risky early on in their development. They were unprofitable. They burned cash aggressively. And many investors avoided them because they simply didn't look "safe." A great example of this is Amazon in its early days. That's what makes CoreWeave (CRWV 4.15%) such an interesting stock today. While the short answer to the headline question is "no, CoreWeave is not a safe stock," that may be exactly why investors should be paying attention to it now. Why CoreWeave has captured Wall Street's attention Many of the companies benefiting from artificial intelligence (AI) are currently building applications such as chatbots, AI assistants, and software tools. CoreWeave operates on a different layer. It provides the computing infrastructure needed to train and run AI models. That includes GPUs, data centers, networking, and orchestration software that help companies scale AI workloads efficiently. In simple terms, CoreWeave helps power AI infrastructure. That puts the company in a powerful position. AI demand doesn't behave like a normal technology cycle. As models become larger and more widely adopted, computing demand actually grows alongside them. Training workloads increase, while inference -- the process of running AI models in real-world applications -- expands continuously. That creates a potentially enormous opportunity for companies supplying AI infrastructure, such as CoreWeave. CoreWeave has already secured massive long-term agreements with some of the largest players in AI. More importantly, it is becoming increasingly embedded in how those companies operate. Once customers deploy AI workloads at scale on a specific infrastructure setup, switching providers is not always simple. It introduces cost, operational complexity, and potential disruption. That creates a subtle but important dynamic: CoreWeave is not just renting out compute. It is trying to become part of the infrastructure layer on which the...
Target (TGT) shares are inching higher on Tuesday as investors react favorably to a major executive shake-up ahead of tomorrow’s highly anticipated Q1 earnings report. The retail giant has hired veteran Jeff England as its new chief of global supply chain and logistics to resolve its long-standing inventory-related challenges. At the time of writing, Target stock is up about 25% versus the start o...
Target (TGT) shares are inching higher on Tuesday as investors react favorably to a major executive shake-up ahead of tomorrow’s highly anticipated Q1 earnings report. The retail giant has hired veteran Jeff England as its new chief of global supply chain and logistics to resolve its long-standing inventory-related challenges. At the time of writing, Target stock is up about 25% versus the start of this year (2026). What England’s Appointment Means for Target Stock Bringing in Jeff England, who spent 18 years climbing the ranks at rival Walmart (WMT), is a statement of intent from Target’s new chief executive, Michael Fiddelke. The retailer is still struggling with an inventory drought, marked by several quarters of weak or declining sales due to empty shelves and out-of-stock merchandise. England’s appointment is bullish for TGT shares as he brings a proven track record in automation and logistics engineering. Target could utilize his blueprint to scale its newly opened Houston receive center facility — finally balancing its $6 billion supply chain initiative, lowering costly transportation overhead, and recapturing lost foot traffic. Why Caution Is Warranted in Playing TGT Shares Despite the management shake-up, Target shares remain a risky bet ahead of the retailer’s quarterly print. The company still relies heavily on discretionary goods, which makes it more exposed to the Iran war that may hit consumer sentiment as the year unfolds. Plus, Target's push to match Walmart and Amazon (AMZN) on same-day fulfillment has cannibalized margins, because its retail stores double as fulfillment centers, overcrowding its logistics network. And experts believe the recent price cuts on 3,000 items will compress margins even further. All in all, at about 15x forward earnings, Target’s valuation looks rather steep for a business facing shrinking traffic. On the plus side, however, it pays a healthy dividend yield of 3.62%. What’s the Consensus Rating on Target? What’s also wort...
Shares of Arm Holdings (NASDAQ:ARM) are trading higher by 4% in midday action Tuesday, extending a year that has put the chip-IP designer in a class of its own among semiconductor design names. ARM stock is up 102% year to date (YTD) through Monday, thereby doubling in under five months. The rest of the chip-IP ... Arm Holdings Has Doubled in 2026. Is It Outperforming Other Chip-IP Stocks Like Syn...
Shares of Arm Holdings (NASDAQ:ARM) are trading higher by 4% in midday action Tuesday, extending a year that has put the chip-IP designer in a class of its own among semiconductor design names. ARM stock is up 102% year to date (YTD) through Monday, thereby doubling in under five months. The rest of the chip-IP ... Arm Holdings Has Doubled in 2026. Is It Outperforming Other Chip-IP Stocks Like Synopsys, Cadence, and Qualcomm?
Andy Burnham will face Reform UK’s Robert Kenyon in next month’s crucial Makerfield byelection in a clash that could change the course of British politics for years to come. Reform are billing Kenyon, a plumber and army reservist who contested the seat just outside Wigan in the 2024 general election, as a local champion taking on a professional politician who is using the seat for his own advantag...
Andy Burnham will face Reform UK’s Robert Kenyon in next month’s crucial Makerfield byelection in a clash that could change the course of British politics for years to come. Reform are billing Kenyon, a plumber and army reservist who contested the seat just outside Wigan in the 2024 general election, as a local champion taking on a professional politician who is using the seat for his own advantage. Kenyon, however, faced immediate scrutiny of his social media activity. Deleted posts on X show he appeared to cast doubt on the efficacy of a vaccine, interacted with a Dutch far-right influencer and praised Donald Trump. The Conservatives also asked why Kenyon’s account had been suspended. Burnham, the Greater Manchester mayor, was selected by Labour’s national executive committee. No other candidates were on the shortlist despite others having applied. The byelection is expected to take place on 18 June. Burnham has been open about wanting to return to Westminster to change Labour’s direction at the national level, and a leadership bid against Keir Starmer is widely assumed if he wins. He said in a statement that he was humbled to have been selected and promised to put the spotlight on what he said were neglected parts of the UK such as Makerfield. Announcing Kenyon as Reform’s candidate, the party leader, Nigel Farage, characterised the byelection as a “David versus Goliath battle”. In a video posted by Reform, Kenyon took aim at Burnham, saying he was using Makerfield as a stepping stone, a likely attack line in the weeks ahead despite Burnham’s family home being nearby. View image in fullscreen A view of Aston-in-Makerfield town centre. Photograph: Joel Goodman/The Guardian “Labour and probably the other parties have got career politicians. They go to private school, to university, they get a job at a thinktank or they are an assistant to an MP and then before you know it they are parachuted into somewhere they have never even visited to stand as an MP,” he said. K...
He added: "It is, on the face of it, difficult to reconcile the current scope of Cambridge Aerospace's operations with the restriction that you avoid defence matters entirely, and in the absence of a fresh application for advice in view of changes to the nature of the business of Cambridge Aerospace under your chairship."
He added: "It is, on the face of it, difficult to reconcile the current scope of Cambridge Aerospace's operations with the restriction that you avoid defence matters entirely, and in the absence of a fresh application for advice in view of changes to the nature of the business of Cambridge Aerospace under your chairship."
JHVEPhoto Bankers are preparing to sell $49 billion of debt for Paramount Skydance's ( PSKY ) planned purchase of Warner Bros. Discovery ( WBD ). A premarketing process for the debt is expected to start in the next couple of weeks, according to a Bloomberg report on Tuesday, which cited people familiar with the matter. Paramount and Warner Bros. Discovery declined to comment to Bloomberg. Apollo G...
JHVEPhoto Bankers are preparing to sell $49 billion of debt for Paramount Skydance's ( PSKY ) planned purchase of Warner Bros. Discovery ( WBD ). A premarketing process for the debt is expected to start in the next couple of weeks, according to a Bloomberg report on Tuesday, which cited people familiar with the matter. Paramount and Warner Bros. Discovery declined to comment to Bloomberg. Apollo Global ( APO ) Bank of America ( BAC ). and Citigroup ( C ). provided the initial financing — first set at $57.5 billion. Last month, BofA and Citi sold down the financing — by then reduced to $49 billion — to a group of 18 banks, according to the report. Separately on Tuesday, Wall Street banks started a leveraged loan sale for the Warner Bros. ( WBD ) deal, with proceeds expected to be used to refinance a temporary credit facility provided by JPMorgan ( JPM ), according to another Bloomberg report. More on Paramount Skydance Corporation, Warner Bros. Discovery Netflix, Disney, FuboTV, WBD And The Streaming Media Landscape Paramount Skydance Corporation (PSKY) Presents at MoffettNathanson's Media, Internet & Communications Conference Transcript Warner Bros. Discovery: Actually Soft, Not Strong, Earnings; But The Merger Would Cure All, Will It Close? ‘Michael’ moonwalks back to No. 1 as domestic box office hits $106M weekend Tudor adds Warner Bros. Discovery stake, boosts SPY, trims QQQ in Q1
A few syntactical tics – and the verdict of an AI detection platform – have sparked a furore over the possibility that a short story given a prestigious literary award was written by AI. The foundation that awarded the prize and Granta, the magazine that published the winning story, said they had considered the allegations but had not reached a conclusion as to whether they were true. “It may be t...
A few syntactical tics – and the verdict of an AI detection platform – have sparked a furore over the possibility that a short story given a prestigious literary award was written by AI. The foundation that awarded the prize and Granta, the magazine that published the winning story, said they had considered the allegations but had not reached a conclusion as to whether they were true. “It may be that the judges have now awarded a prize to an instance of AI plagiarism – we don’t yet know, and perhaps we never will know,” the publisher of Granta, Sigrid Rausing, said. The Serpent in the Grove was named as the winning entry for the Commonwealth prize from the Caribbean on Saturday and published in Granta magazine. In “a voice of restraint and quiet authority”, according to the judging committee, it narrates an intense episode in a troubled marriage, and is set in a farmhouse next to an enchanted grove. Shortly after it was published, internet sleuths – and a few literary critics – seized upon the work and its author, Jamir Nazir, reportedly a 61-year-old from Trinidad and Tobago with few publications to his name. Ethan Mollick, a professor at the University of Pennsylvania, wrote on Bluesky: “100% AI generated story just won the Commonwealth prize for the Caribbean region,” calling it “a Turing test of sorts”. As evidence, he cited Pangram, an AI detector, which said the work was AI-generated, but also said: “Come on, if you know you know.” Another commentator, previously employed at Palantir, said there were “plenty of other obvious markers of AI writing” in the story, including a litany of “not x, but y” sentence structures, by now a familiar trope. Other pundits dug into what appeared to be Nazir’s LinkedIn profile, where he discusses matters including the AI arms race and AI replacing jobs. The accusations are another episode in an ongoing, frenetic conversation about whether artists and creators are passing off AI-generated work as their own – and whether publicat...
AGNC Investment ( AGNC ) stayed under pressure near ~$10.18, falling nearly ~3% over the past week and around ~6% in the last month, as investors reacted to weaker book value trends despite strong income performance. On a YTD basis , AGNC stock is down 5.18%, sharply underperforming the broader S&P 500 ( SP500 ) , which has gained 8.14%. The mortgage REIT reported Q1 results on April 20, where net...
AGNC Investment ( AGNC ) stayed under pressure near ~$10.18, falling nearly ~3% over the past week and around ~6% in the last month, as investors reacted to weaker book value trends despite strong income performance. On a YTD basis , AGNC stock is down 5.18%, sharply underperforming the broader S&P 500 ( SP500 ) , which has gained 8.14%. The mortgage REIT reported Q1 results on April 20, where net spread and dollar roll income came in at $0.42 per share, beating analyst estimates of $0.37. The figure also improved from $0.35 in Q4 2025, though it slipped slightly from $0.44 reported a year ago. Net interest income surged to $319M from $206M in the prior quarter and $159M last year, supported by stronger spread performance. AGNC’s annualized net interest spread improved to 2.06% from 1.81% in Q4, while its investment portfolio remained stable at $94.7B. However, tangible net book value dropped to $8.38 per share from $8.88 at the end of 2025, pushing economic return on tangible common equity down to negative 1.6%. President and CIO Peter Federico said market optimism earlier in the quarter faded in March due to rising geopolitical tensions tied to the Iran conflict. Despite the pressure, AGNC highlighted its strong dividend profile, noting it has paid more than $15B in common stock dividends since inception. Both Wall Street and Seeking Alpha analysts currently maintain a buy rating of 3.55 on the stock. More on AGNC Investment AGNCO: This 8.75% Yielding Preferred Share Isn't The Highest, But My Favorite Don't Chase mREIT Yield: Rithm Outshines AGNC Investment AGNC Is Yielding 13%, And Top Rated: We Predict A Dividend Hike In 2027 Dividend Roundup: Otis Worldwide, Eaton, AGNC Invest, Morgan Stanley, and more Agnc signals 15%-17% returns at ~150 bp MBS spreads as April tangible book value rises ~6%