Chinnachart Martmoh/iStock via Getty Images Cogent Overview Cogent Biosciences, Inc. ( COGT ) has made a lot of progress since my last look in February 2023. My focus was on Cogent’s TKI, bezuclastinib, in gastrointestinal stromal tumors, or GIST. I believed that bezuclastinib and sunitinib was a promising combination in second-line GIST, pending Phase 3 (PEAK) confirmation. Perhaps the biggest de...
Chinnachart Martmoh/iStock via Getty Images Cogent Overview Cogent Biosciences, Inc. ( COGT ) has made a lot of progress since my last look in February 2023. My focus was on Cogent’s TKI, bezuclastinib, in gastrointestinal stromal tumors, or GIST. I believed that bezuclastinib and sunitinib was a promising combination in second-line GIST, pending Phase 3 (PEAK) confirmation. Perhaps the biggest development during this time was not that bezuclastinib and sunitinib exceeded expectations in PEAK , but bezuclastinib’s newfound utility in nonadvanced systemic mastocytosis (NonAdvSM) and advanced systemic mastocytosis (AdvSM). Although Sanofi’s ( SNY ) (formerly, Blueprint) TKI, Ayvakit, has a multi-year head start in this market, bezuclastinib’s potential should not be underappreciated. Author's Compilation Indeed, Cogent has its eyes on three separate approvals for bezuclastinib: Cogent Below, I perform a sum-of-the-parts, or SOTP, valuation to inform whether or not COGT is still worth a Buy rating at these prices, as its stock has skyrocketed 169% since my last look. Data by YCharts GIST There are roughly 6k cases of GIST in the U.S. per year. Initial management includes imatinib, another TKI. About half of these patients will experience disease progression. Sunitinib has been the SoC second-line agent for decades. Cogent’s bezuclastinib did something special in PEAK that other TKIs (i.e., ripretinib) could not. Combined with sunitinib, against sunitinib alone, it nearly doubled (79% improvement) mPFS. Author's Compilation In INTRIGUE, Deciphera gambled on ripretinib being a “cleaner” and “better” drug than sunitinib, but failed . Cogent’s “synergy” play paid off mightily. So, although the U.S. Target Pop. is ~3,000 in 2L GIST, I can assume a robust 45% peak share. Other assumptions include 12% WACC, 88% POS (NDA stage), 2027 Launch, 2031 Peak, 2038 LOE, 1.5% Pop. Growth, $380k Net Price, 20% Yr 1 Uptake, 55% Launch OpEx for 2 Yrs (first launch for company), 30% Steady...
coffeekai/iStock via Getty Images A price war among Canadian telecom providers is fueling a “race to the bottom,” as these cheaper rates haven't translated into increased volume, leading TD Cowen analyst Vince Valentini to pull his remaining Buy rating on the three major players. Valentini now views Rogers Communications ( RCI ), BCE Inc. ( BCE ), and TELUS Corp. ( TU ) as a Hold and lowered his a...
coffeekai/iStock via Getty Images A price war among Canadian telecom providers is fueling a “race to the bottom,” as these cheaper rates haven't translated into increased volume, leading TD Cowen analyst Vince Valentini to pull his remaining Buy rating on the three major players. Valentini now views Rogers Communications ( RCI ), BCE Inc. ( BCE ), and TELUS Corp. ( TU ) as a Hold and lowered his average revenue per user (ARPU) growth estimates for each by 100 basis points across the next seven quarters. "Enough damage has already been done to justify a more cautious stance with our ARPU growth forecasts," he says. For every dollar decline in wireless service revenue, TD Cowen assumes that 70 cents will flow through to EBITDA. "We have not assumed any increase in net subscriber growth because, in our view, all carriers showing similar price aggression is simply a race to the bottom with no net winner on volume,” Valentini warns. With today’s downgrades, Cowen does not have a Buy rating on any of the five major Canadian telecommunication or cable names, a first in TD Cowen’s 30 years of coverage. “We see market wireless pricing dynamics continuing to weigh on sentiment and financial metrics,” Valentini says, and that the aggressive pricing is not translating into increases in subscriber volume across the Canadian telecom industry, instead causing elevated churn and a negative repricing cycle. Valentini also warns that there is incremental service revenue risk in the area of $50M per incumbent carrier if the recent Canadian Radio-television and Telecommunications Commission (CRTC) decision banning activation fees cannot be either overturned or somehow offset. Of the three, the analyst is more concerned about TELUS, anticipating a 30% cut to its dividend by the end of this year. In addition to the downgrade to the three, Valentini also lowered his price target for BCE ( BCE ) by 10% to $37, by 13% for Rogers ( RCI ) to $56, and by 9.5% for TELUS ( TU ) to $19. The downg...
There's been a lot said about the massive spending on artificial intelligence (AI) infrastructure, with Meta Platforms , Alphabet , Amazon , and Microsoft alone expected to spend a collective $700 billion this year on new data centers and the equipment that fills them, such as chips, networking equipment, server racks, and cooling systems. But take a moment to absorb that number -- $700 billion. F...
There's been a lot said about the massive spending on artificial intelligence (AI) infrastructure, with Meta Platforms , Alphabet , Amazon , and Microsoft alone expected to spend a collective $700 billion this year on new data centers and the equipment that fills them, such as chips, networking equipment, server racks, and cooling systems. But take a moment to absorb that number -- $700 billion. Fewer than 20 publicly traded companies worldwide have market caps that large. It's also more than the gross domestic products of many countries, including Israel, the United Arab Emirates, and Sweden. Undoubtedly, there's going to be a lot of money changing hands this year and in the years to come as tech companies build out their AI data centers. If you're looking for some slam-dunk stock buying opportunities to capitalize on that trend, consider Nvidia (NASDAQ: NVDA) , Digital Realty Trust (NYSE: DLR) , and Credo Technology Group (NASDAQ: CRDO) . Continue reading
Traditional grocery stores face competition on multiple fronts, creating a price-driven, margin-squeezing battle for market share. They have always had to fend off warehouse clubs including Costco and Sam's Club while battling Walmart and Target, which have increased their investment in the grocery ...
Traditional grocery stores face competition on multiple fronts, creating a price-driven, margin-squeezing battle for market share. They have always had to fend off warehouse clubs including Costco and Sam's Club while battling Walmart and Target, which have increased their investment in the grocery ...
Advanced Micro Devices (AMD) has kept investors watching closely, with the share price sitting at US$210.21 and recent returns mixed across the past week, month and past three months. See our latest analysis for Advanced Micro Devices. The 1-year total shareholder return of 104.17% contrasts with a year-to-date share price return decline of 5.93%, suggesting momentum has cooled recently even after...
Advanced Micro Devices (AMD) has kept investors watching closely, with the share price sitting at US$210.21 and recent returns mixed across the past week, month and past three months. See our latest analysis for Advanced Micro Devices. The 1-year total shareholder return of 104.17% contrasts with a year-to-date share price return decline of 5.93%, suggesting momentum has cooled recently even after a very strong run for longer term holders. If you are looking beyond AMD for other AI driven...
Earnings Call Insights: Lindsay Corporation (LNN) Q2 2026 Management View “We are closely monitoring the situation with our top priority remaining the safety of our employees and partners in the region.” (President, CEO & Director Randy Wood) Wood said the MENA market is “a strong source of growth” for international irrigation and that deliveries tied to the company’s “most recent project are mean...
Earnings Call Insights: Lindsay Corporation (LNN) Q2 2026 Management View “We are closely monitoring the situation with our top priority remaining the safety of our employees and partners in the region.” (President, CEO & Director Randy Wood) Wood said the MENA market is “a strong source of growth” for international irrigation and that deliveries tied to the company’s “most recent project are meaningful to our revenue,” adding, “The project remains on schedule, and our supply chains are currently operating without disruption.” “In North America, our irrigation business customers continued to delay large capital purchases given current farm economics, which, as expected, resulted in lower unit sales volumes in the quarter.” (President, CEO & Director Wood) He said international irrigation was “flat to slightly down year-over-year,” citing “lower sales volumes in Brazil and the timing of project revenue in the MENA region,” and added that in Brazil “high interest rates and limited access to credit continue to constrain growers’ ability to finance capital equipment purchases.” “Total revenues for the second quarter of fiscal 2026 were $157.7 million, a decrease of 16% compared to $187.1 million in the prior year.” (CFO & Senior VP Samuel Hinrichsen) He said operating income was $13 million and net earnings were $12.0 million, or $1.15 per diluted share, and added that the year-over-year decline reflected “lower operating income and a higher effective tax rate.” “During the quarter, we introduced 2 new products” at an industry trade show: “The AlphaGuard channeling device” and “The Road Runner” truck-mounted attenuator. (President, CEO & Director Wood) He framed the launch as reflecting “our investment in innovation and the growing demand for efficient and safe roadway solutions.” Outlook “We expect softer market conditions to persist in the near term in North America.” (President, CEO & Director Wood) He said the company is “not seeing the traditional pickup in spring ...
In March 2026, Broadcom reported Q1 results ahead of expectations, highlighted very large growth in AI semiconductor revenue, and, together with Carahsoft, secured a five-year, US$970 million blanket purchase agreement from the Defense Information Systems Agency to streamline software procurement across key U.S. Department of War agencies. These developments reinforce Broadcom’s dual identity as b...
In March 2026, Broadcom reported Q1 results ahead of expectations, highlighted very large growth in AI semiconductor revenue, and, together with Carahsoft, secured a five-year, US$970 million blanket purchase agreement from the Defense Information Systems Agency to streamline software procurement across key U.S. Department of War agencies. These developments reinforce Broadcom’s dual identity as both an AI hardware supplier and a growing infrastructure software provider with expanding...
India’s homegrown artificial intelligence startup, Sarvam AI , is close to raising $300 million to $350 million as it seeks to build a domestic player that can compete with leaders from the US and China. The Bangalore-based company is raising the money at a valuation of $1.5 billion to $1.55 billion and could close the round as soon as next week, according to people familiar with the matter, askin...
India’s homegrown artificial intelligence startup, Sarvam AI , is close to raising $300 million to $350 million as it seeks to build a domestic player that can compete with leaders from the US and China. The Bangalore-based company is raising the money at a valuation of $1.5 billion to $1.55 billion and could close the round as soon as next week, according to people familiar with the matter, asking not to be named because the discussions aren’t yet public. Bessemer Venture Partners is expected to lead the round, with Nvidia Corp. , Amazon.com Inc. and Prosperity7 Ventures also participating, the people said. Sarvam took a starring role at Prime Minister Narendra Modi’ s AI summit in February, unveiling an AI model that is tailored to the languages and cultures of the world’s biggest market. Modi and his government have made a forceful case that countries beyond the US and China need to control their own destiny with the emerging technology. Sarvam was founded by two AI researchers, Vivek Raghavan and Pratyush Kumar, in 2023. Sarvam’s models are built to be used through voice commands and are accessible through 22 Indian languages, which the company has said will be a competitive advantage in the country of 1.45 billion where the vast majority can’t read, write or type in English. The goal is to take on the likes of OpenAI and Alphabet Inc. , whose models often struggle with Indian languages. Sarvam also offers what’s known as “agentic” AI models that can carry out tasks like coding or meeting planning in large part autonomously and with minimal human intervention. The company says its agents could drive enterprise automation in one of the world’s fastest growing economies. “Today we show we can bring our own AI to a billion Indians,” Sarvam co-founder Kumar said in February at the unveiling.
The former British foreign secretary is among 3,000 signatories, including leading members of Jewish diaspora, to open letter to Isaac Herzog The former British foreign secretary Malcolm Rifkind is among leading members of the Jewish diaspora urging the Israeli president, Isaac Herzog, to intervene to stop “attacks by Jewish extremists” on Palestinians in the West Bank. An open letter to Herzog fa...
The former British foreign secretary is among 3,000 signatories, including leading members of Jewish diaspora, to open letter to Isaac Herzog The former British foreign secretary Malcolm Rifkind is among leading members of the Jewish diaspora urging the Israeli president, Isaac Herzog, to intervene to stop “attacks by Jewish extremists” on Palestinians in the West Bank. An open letter to Herzog facilitated by the London Initiative – a liberal Zionist network of 360 people, including eminent Jewish, Israeli and Israeli Palestinian figures – has attracted more than 3,000 signatories, including diplomats, philanthropists, rabbis and academics from Australia, Canada, across Europe, South Africa the UK and US. It follows a spate of killings and arson attacks by settlers on Palestinian civilians in March. Continue reading...
Trump Fires Pam Bondi As Attorney General, Blanche To Be Acting AG Update (1315ET): President Donald Trump has ousted Attorney General Pam Bondi , multiple outlets report. Deputy Attorney General Todd Blanche is serving as acting AG in the interim. The move comes amid White House frustration with Bondi’s leadership at the Justice Department - particularly her handling of the Jeffrey Epstein files ...
Trump Fires Pam Bondi As Attorney General, Blanche To Be Acting AG Update (1315ET): President Donald Trump has ousted Attorney General Pam Bondi , multiple outlets report. Deputy Attorney General Todd Blanche is serving as acting AG in the interim. The move comes amid White House frustration with Bondi’s leadership at the Justice Department - particularly her handling of the Jeffrey Epstein files and what Trump viewed as insufficient aggression in targeting his political opponents. Trump had privately discussed firing her and floated EPA Administrator Lee Zeldin (or Blanche) as a possible replacement. Bondi met with Trump in the Oval Office Wednesday night ahead of his speech to the nation on the war in Iran, where she reportedly was informed of her ouster, according to two sources familiar with the meeting. One of those sources said that by the time Trump took his place behind the podium for the address, Bondi already lost her job and was on her way back to Florida. - Fox News And according to the WSJ, Trump weighed firing her in January but was persuaded not to do so . In a Thursday statement, Trump called Bondi "a Great American Patriot and a loyal friend, who faithfully served as my Attorney General over the past year," adding "she will be transitioning to a much needed and important new job in the private sector, to be announced at a date in the near future, and our Deputy Attorney General, and a very talented and respected Legal Mind, Todd Blanche, will step in to serve as Acting Attorney General. " Back to private practice? * * * ReadyWise Spring Sale - ends April 10 . Stock up. Earlier: Leaky little sharks are circling in DC - telling the NY Times and CNN that Pam Bondi may soon be out as Attorney General, and replaced with EPA Administrator Lee Zeldin. The frustration, per sources close to the White House cited by The New York Times and CNN , centers squarely on Bondi's catastrophic mishandling of the Jeffrey Epstein files - a saga ZeroHedge has chronicled ...