Yuliia Kaveshnikova/iStock via Getty Images While US markets have raced to new all-time highs in recent years, not all stocks have participated in the rally. Over the past five years, shares of sequencing solution company Pacific Biosciences of California, Inc. ( PACB ) have lost more than 95%. While the stock more than doubled at one point last year, much of those gains have been wiped out in rec...
Yuliia Kaveshnikova/iStock via Getty Images While US markets have raced to new all-time highs in recent years, not all stocks have participated in the rally. Over the past five years, shares of sequencing solution company Pacific Biosciences of California, Inc. ( PACB ) have lost more than 95%. While the stock more than doubled at one point last year, much of those gains have been wiped out in recent months. Recently, the company reported its Q1 results , featuring a revenue guidance cut for the year, at a time when the company needs to be doing much better. Previous Coverage of the Name I first took a look at Pacific Biosciences last June, with shares trading below a dollar and potentially heading for a reverse split . I detailed how analyst revenue estimates continued to head much lower, and large losses were leading to significant cash burn. The stock has been very volatile since, and even though it has risen almost 25% over that time, that gain actually trails the S&P 500 by a couple of percentage points. A Look at the Q1 Results and Guidance Update For the March period, the company reported revenues of almost $37.2 million. That figure was up very slightly from the year-ago period, but the street was looking for nearly $40 million. Management detailed a record quarter for consumables revenue of $21.8 million but noted that instrument revenues were rather weak. The company has continued to talk about weak government and academic spending, a theme I discussed in my prior article thanks to the current Trump administration. When it comes to the income statement, you really have to look at the non-GAAP numbers. The GAAP ones are really messy, since last year's period had a massive write-down of assets, and this year's one had a decent gain due to the sale of short-read sequencing assets. Overall, the adjusted loss was nearly $36 million in Q1 2026. While that was an improvement from $44.4 million seen a year earlier, it's still nearly a dollar of losses for every do...
悉尼燈光音樂節近90架無人機墜港 險擊中工作人員 主辦單位取消周二及周三表演 To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video 【有線新聞】澳洲的悉尼燈光音樂節舉行期間，近90架無人機從空中墜落。主辦單位因應事故，取消周二及三的...
悉尼燈光音樂節近90架無人機墜港 險擊中工作人員 主辦單位取消周二及周三表演 To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video 【有線新聞】澳洲的悉尼燈光音樂節舉行期間，近90架無人機從空中墜落。主辦單位因應事故，取消周二及三的無人機表演。 閃亮發光的無人機在悉尼達令港上空進行「星際之旅」表演時，多架無人機忽然從高空墜落，跌入水中並濺起水花。有目擊者表示，多名工作人員近乎被無人機擊中。負責操作的英國無人機公司表示，由於無線電頻率出現意外的變化，令多架無人機啟動失效安全降落程序，強調沒有無人機脫離安全範圍。
Even semiconductor chips seem to be on GLP-1s now, with Huawei announcing Monday that it’ll launch an ultra-thin 1.4-nanometer chip by 2031 using new “LogicFolding” tech. Huawei plans to first use LogicFolding — a process of folding and stacking circuits to shorten chips’ wiring — to make its Kirin smartphone chips this fall. In the semiconductor world, thinner means more powerful. Currently, Chin...
Even semiconductor chips seem to be on GLP-1s now, with Huawei announcing Monday that it’ll launch an ultra-thin 1.4-nanometer chip by 2031 using new “LogicFolding” tech. Huawei plans to first use LogicFolding — a process of folding and stacking circuits to shorten chips’ wiring — to make its Kirin smartphone chips this fall. In the semiconductor world, thinner means more powerful. Currently, China’s most advanced chipmaking abilities are believed to yield 7-nanometer chips. Taiwan’s TSMC, the leader in chip manufacturing, makes 2-nanometer chips with a plan for 1.4-nanometer chips in 2028. The Chip Queen Ditches Moore’s Law Huawei’s He Tingbo, who’s known in tech circles as the “chip queen,” is leading Huawei’s semiconductor biz through a stage it describes as “extreme survival mode.” The Chinese company was blacklisted from receiving advanced semiconductor technology in 2019 due to national security concerns. That left an Nvidia-sized hole for Huawei to fill, but it also left Huawei without much of the tech it needs to make advanced semiconductors, including key lithography equipment. He thinks Huawei can compete on a global scale despite the restrictions: During a “semiconductor symposium” in Shanghai on Monday, He talked about the Tau Scaling Law. It’s Huawei’s answer to Moore’s Law, which claims the number of transistors in a microchip will double every two years while costs halve. Nvidia CEO Jensen Huang is known for saying semiconductor development is outpacing the doubling timeline of Moore’s Law. The Tau Scaling Law dispenses with the measure of progress that Moore’s Law sets altogether. Instead of doubling the number of transistors, the Law of Tao basically measures data transmission speed. Focusing on improving this metric with LogicFolding could help Huawei improve chips without relying on the latest lithography equipment. Wait and See: Stacked designs, like the ones made by LogicFolding, can make chips hotter. Keeping chips cool is a major cost for tech...
Higher prices could persist over the summer even if ceasefire talks between the US and Iran bear fruit, consumers have been warned, with economic shock waves likely to be felt “for many months to come”. Disruption to global shipping, coupled with soaring prices for energy and raw materials, have driven up costs for UK companies, with the impact already filtering through to prices paid at the tills...
Higher prices could persist over the summer even if ceasefire talks between the US and Iran bear fruit, consumers have been warned, with economic shock waves likely to be felt “for many months to come”. Disruption to global shipping, coupled with soaring prices for energy and raw materials, have driven up costs for UK companies, with the impact already filtering through to prices paid at the tills, according to fresh inflation figures. Retailers have responded by launching promotions to tempt bargain hunters but businesses said it was getting harder to stave off price increases, and called on the government to go beyond existing measures to help alleviate the pressure. Shop price inflation is already on the rise, according to figures from the British Retail Consortium (BRC). Furniture and health and beauty products are among the items that have risen most in recent weeks, driving an increase in shop prices of 1.2% year on year in May. The rate was slightly above the three-month average of 1.1%. High oil prices and the ripple effect of the prolonged closure of the strait of Hormuz shipping channel were among the factors cited by the BRC. Customers can still find bargains on TV and audiovisual equipment, it said, as retailers target football fans getting “World Cup ready” for this summer’s tournament in the US, which starts next month. Intense competition between supermarkets has also kept a lid on food price inflation, which fell to 2.7% in May, below the longer-term average of 3.1%. However, while some promotions were likely to be extended over the summer as retailers compete hard for consumers’ disposable income, the trade body voiced doubts about the broader outlook for cost-conscious consumers. “While retailers work hard to keep prices down for customers, they continue to face significant cost pressures, including higher energy bills and disruption linked to the conflict in Iran,” said Helen Dickinson, the BRC’s chief executive. “Businesses cannot absorb these co...
Like so many Britons, I usually consult a weather app before venturing out of the house – and often cancel plans if I don’t like what I see. Here’s what happened when I went cold turkey for a week When I heard on the radio that more than half of British people would consider cancelling an outing if they saw a 40% chance of rain all day on their weather app, I felt seen. I, too, am a slave to my ap...
Like so many Britons, I usually consult a weather app before venturing out of the house – and often cancel plans if I don’t like what I see. Here’s what happened when I went cold turkey for a week When I heard on the radio that more than half of British people would consider cancelling an outing if they saw a 40% chance of rain all day on their weather app, I felt seen. I, too, am a slave to my app. Not that I would ever make a decision based on one whole-day percentage. I pore over three-hourly breakdowns for chances of rain versus minutes of sunshine. If rain is on the cards, I check the probable millimetres. Less than one? I may well throw caution to the wind. Speaking of which, wind speed and direction must also be considered, along with overall and “feels like” temperatures. For the cherry on top, I’ll compare notes with a loved one’s app if they use a different one, quietly mistrusting theirs, and simmering in silent rage if theirs wins. I’ll admit, though, that my compulsion to check my app (I long ago chose WeatherPro, which I knew nothing about, but liked its layout and name) is borderline neurotic; I fret over probabilities and outfit appropriateness, when I could simply step outside for real-time hyper-local accuracy. I can lose procrastinatory hours consulting long-range forecasts, or checking the weather in Melbourne (where my sister lives) and holiday destinations I have no immediate plans to visit. Continue reading...
His detractors say he shouldn’t be making pop music in times of war and destruction. His millions of fans say he has given them permission to celebrate their culture and their cause The first time I heard a song by Saint Levant, only three years ago, was in a world that does not exist any more. Gaza’s buildings were intact, as were its schools and roads and markets and mosques. My home city of Kha...
His detractors say he shouldn’t be making pop music in times of war and destruction. His millions of fans say he has given them permission to celebrate their culture and their cause The first time I heard a song by Saint Levant, only three years ago, was in a world that does not exist any more. Gaza’s buildings were intact, as were its schools and roads and markets and mosques. My home city of Khartoum in Sudan was standing, as it had for centuries. Back then, I could scroll for fun, not in dread. I could stumble, say, in late 2022, upon an arresting clip on TikTok of a song by an Arab artist with a pun for a name; Saint Levant, a play on Saint Laurent – the icon of western style had been Arabised in homage to the Middle East’s Levant region. I began to see the same song all over my social media. In the video, Saint Levant, then 22, is in a white vest and brown trousers. A gold pendant chain dangles on his chest, a tattoo encircles his left arm. He starts by rapping in English, telling the woman he is wooing that “he’s not toxic, he’s broken baby”. And then, the twist, as he switches to Arabic, then French, then English again. Like a wholesome boy next door, he tells her to send his regards to her grandmother and her brother. Then says that he wants to make her forget about her ex, he wants her overthinking all her texts, he wants the neighbours to hear her yell. “Lover boy Levant is back in the building,” he declared. Continue reading...
The trial of former Democratic Unionist party (DUP) leader Sir Jeffrey Donaldson for alleged sex offences is set to begin in a case that triggered a political earthquake in Northern Ireland. Donaldson, 63, is charged with rape, gross indecency and other sexual offences spanning 21 years. His wife, Eleanor Donaldson, 60, is charged with aiding and abetting rape and indecent assault and will be subj...
The trial of former Democratic Unionist party (DUP) leader Sir Jeffrey Donaldson for alleged sex offences is set to begin in a case that triggered a political earthquake in Northern Ireland. Donaldson, 63, is charged with rape, gross indecency and other sexual offences spanning 21 years. His wife, Eleanor Donaldson, 60, is charged with aiding and abetting rape and indecent assault and will be subject to a trial of facts. A heavy security and media presence is expected at Newry crown court for the opening of a trial on Tuesday that is expected to last at least four weeks. Donaldson, a former MP for Lagan Valley in County Down, was a dominant figure in unionism and a key player at Westminster who helped to broker the post-Brexit Windsor framework on Northern Ireland’s trading arrangements. Police arrested him and his wife at their home and questioned them in March 2024. He resigned as an MP and DUP leader and was suspended from the party. The case threw the DUP and the Stormont executive into disarray. He is charged with 18 offences involving two alleged victims. The rape charge alleges he had unlawful sexual intercourse with the alleged victim without her consent on a date unknown between 1985 and 1991. Nine allegations of indecent assault span 1985 to 2006. He is also charged with committing an act of gross indecency towards a child between 2005 and 2006. Lady Donaldson faces five charges relating to aiding and abetting her husband’s alleged offending. Both deny the charges and have pleaded not guilty. After several delays to the trial, the judge, Paul Ramsey, ruled last week that Eleanor Donaldson was unfit to stand trial on mental health grounds and would instead face a trial of facts. “The interests of justice require that this case be progressed in a manner that is fair to all parties, but also as expeditiously as such fairness permits,” he said. A trial of facts tests the evidence but cannot result in a criminal conviction. Lawyers will represent Eleanor Donald...
Protests over the production of cancer-linked Pfas chemicals have spread across India, after an investigation revealed that an Italian factory shut down due to an environmental scandal was bought by an Indian company and partly rebuilt. At the end of last year, the Guardian revealed that the former Miteni plant in Vicenza had been acquired by the Indian company Laxmi Organic Industries. The factor...
Protests over the production of cancer-linked Pfas chemicals have spread across India, after an investigation revealed that an Italian factory shut down due to an environmental scandal was bought by an Indian company and partly rebuilt. At the end of last year, the Guardian revealed that the former Miteni plant in Vicenza had been acquired by the Indian company Laxmi Organic Industries. The factory produced Pfas and was shut down in 2018 after being linked to one of Italy’s worst environmental contamination scandals. In June 2025, former Miteni executives were convicted over contamination linked to the plant, in a first-instance ruling widely seen as a landmark for environmental justice in Europe. The factory left behind the contamination of one of Europe’s largest aquifers, affecting more than 350,000 people across the provinces of Vicenza, Verona and Padua through the drinking water. Miteni’s workers were worst affected, with one former employee showing one of the highest concentrations of Pfas ever recorded in human blood. High levels of Pfas in the blood are associated with increased risk of cancer, cardiovascular diseases, liver and kidney damage, reproductive disorders and more. The factory’s equipment was dismantled, shipped and reassembled in Lote Parshuram, south of Mumbai. Its purpose remained the same: producing Pfas, often referred to as “forever chemicals” because of their persistence in the environment. The investigation revealed that Laxmi included in its portfolio some of the same products once manufactured by Miteni and maintained commercial relationships with clients that previously sourced from the Italian company. Laxmi has denied allegations of pollution. Since early 2025, Laxmi’s site in Lote Parshuram has been fully operational, producing chemicals that will be used in pesticides, pharmaceuticals, dyes, cosmetics and other products. After publication of the Guardian’s investigation, protests and political debate have spread across India. On 8 ...
The hallowed radio show is celebrating 75 glorious years – by stepping out of the studio and on to the stage. We sent the Guardian’s food writer (and Ambridge obsessive) along to meet her heroes and find out more I’m very careful not to betray my true levels of excitement when I speak to The Archers actor Susie Riddell, before a nationwide theatre tour to mark the rural radio drama’s 75th annivers...
The hallowed radio show is celebrating 75 glorious years – by stepping out of the studio and on to the stage. We sent the Guardian’s food writer (and Ambridge obsessive) along to meet her heroes and find out more I’m very careful not to betray my true levels of excitement when I speak to The Archers actor Susie Riddell, before a nationwide theatre tour to mark the rural radio drama’s 75th anniversary. I may be an Ambridge superfan but I still don’t want to scare the horses (nor indeed the cows, pigs or sheep). Riddell’s character Tracy Horrobin (who will be appearing with husband, Jazzer, local lush Lilian and cravat-wearing criminal Brian) is not one to hold back however: “It’s like a dream come true for me too!” she confides, slipping easily into broad Borsetshire. “I never thought I’d see the day that I was interviewed by the Guardian. I’ve seen it in the Bull!” The Bull, for the uninitiated, is a half-timbered pub on the village green offering ale, artisanal food and, it seems, copies of the Guardian. It’s a thrilling thought: I briefly entertain the idea of rock star turned vegan baker turned wedding caterer turned pub chef Fallon sitting in the snug, poring over my pie recipes in the Guardian. But it’s stretching credibility to believe an old-fashioned village boozer would find room for any reading material more substantial than Farmers Weekly. Riddell concedes the point. “Maybe Helen left it behind?” Continue reading...
More people regret knee surgery than abortion. So why is the patriarchy still scaring us with lifelong torment? Ireland’s parliament, the Dáil, voted down a reproductive rights amendment bill this month that would have abolished the country’s mandatory three-day waiting period for access to an abortion. Supporters of the unsuccessful reform bill, tabled by the Social Democrats, argued that the del...
More people regret knee surgery than abortion. So why is the patriarchy still scaring us with lifelong torment? Ireland’s parliament, the Dáil, voted down a reproductive rights amendment bill this month that would have abolished the country’s mandatory three-day waiting period for access to an abortion. Supporters of the unsuccessful reform bill, tabled by the Social Democrats, argued that the delay serves no medical purpose. As the bill moved through political debate and media coverage, those defending the requirement to wait three days from the time of requesting an abortion before care can be accessed barely attempted to argue otherwise, instead structuring their opposition to reform around the idea that women cannot be trusted to know what they want. The waiting period, which is not required in most European countries , was repeatedly described as “a cooling off” period; time to “reflect”, “reconsider”, “rethink”. Supporters of the status quo spoke extensively of wanting to save women from feelings of regret. Continue reading...
📖 Reading time: approx. 4 minutes · 761 words · 4,716 characters 🔊 Listen − 1.0× + ⏹ Stop The upcoming Steam Machine appears in the official Vulkan conformance database of the Khronos Group. Technically, this entry is far more interesting than another retailer placeholder, because it does not reflect pricing, wishful thinking, or supply-chain speculation, but a passed API conformance test. Neverth...
📖 Reading time: approx. 4 minutes · 761 words · 4,716 characters 🔊 Listen − 1.0× + ⏹ Stop The upcoming Steam Machine appears in the official Vulkan conformance database of the Khronos Group. Technically, this entry is far more interesting than another retailer placeholder, because it does not reflect pricing, wishful thinking, or supply-chain speculation, but a passed API conformance test. Nevertheless, the following applies: Vulkan-conformant does not mean available, does not mean fast, and certainly does not mean “on store shelves tomorrow.” In the Khronos database, under the date May 23, 2026, there is an entry for an “AMD Steam Machine.” Listed are Vulkan 1.4, CTS version 1.4.5.3, the product family RADV_NAVI33, the Mesa/RADV driver, an “AMD Custom CPU 1772,” and as the operating system a Linux kernel with Valve reference: “Linux 6.16.12-valve6-1-neptune.” This is a rather specific technical fingerprint. The combination of Navi33 and RADV is particularly notable, because it points to an open Linux graphics stack rather than a proprietary Windows driver path. For a SteamOS device, that would be consistent, almost suspiciously sensible. What matters here is the division of roles. The entry is not listed as a classic product announcement by Valve, but becomes visible via the conformance list itself. Khronos is therefore not confirming the launch of a console, but that the submitted implementation passed the Vulkan tests for the specified specification. That is exactly what matters to developers: if a driver cleanly conforms to Vulkan 1.4, the risk decreases that games or middleware will fail because individual implementations behave differently. Khronos itself describes Vulkan 1.4 as a version that moves previously optional features more strongly into the core standard and is therefore intended to simplify cross-platform development. Technically, the entry matches the officially presented direction of the new Steam Machine. Valve positions the device as a compact g...
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Over the last few years, beauty has seen a massive blurring of lines between the wellness and health space and its convergence with beauty. In a presentation at the WWD Beauty CEO Summit, James Hart, president of YipitData, spoke about the current lack of separation between all categories and how inner beauty and supplements are driving growth. While the company has been around for the past 13 yea...
Over the last few years, beauty has seen a massive blurring of lines between the wellness and health space and its convergence with beauty. In a presentation at the WWD Beauty CEO Summit, James Hart, president of YipitData, spoke about the current lack of separation between all categories and how inner beauty and supplements are driving growth. While the company has been around for the past 13 years, YipitData started in beauty in the past two years — but has seen growth quickly in the space. Now, the market research firm works with more than 650 companies, including public and private investors and publicly traded companies. The company has tapped into more than 12 million U.S. shoppers and their purchases both digitally and in-store, accessing data from Amazon, Walmart, Sephora and more. “There’s a convergence of beauty, of wellness and supplements, across all ages,” said Hart. “This blurring is the next stage of growth — for those brands and retailers who take advantage of this are going to be the ones who ultimately win.” One of the noteworthy shifts YipitData has seen is the rise of holistic beauty, i.e., ingestibles, topicals and lifestyle products becoming part of a consumer’s beauty routine. “In every dimension of beauty, these products are becoming more functional. Makeup behaves like skin care, body care is premiumizing,” he continued. The rise in overall health trends such as preventive care, longevity and GLP-1 adoption is also pushing consumers to think about beauty more broadly. “Supplements are the fastest growing sector and we continue to see it to be this over the next 10 years,” said Hart. “$700 million in sales is a real number for beauty supplements alone, but more importantly, it’s growing at a 20 percent rate, which is outpacing the broader beauty market.” Hart shared that this growth points to the why for consumers, who are looking for long-term solutions to systemic concerns and not just a short-term fix. And there’s been a growing awareness ...