图 上周五上午听的是Longevity Biotech Fellowship（LBF）的运营负责人Eric Magro的分享。这个成立约三年的非营利组织专注一件事：把“解决衰老”当成一个值得立项、拨款、招人的工程问题来做。 Eric开场放了一张死亡率曲线。年轻时，我们的死亡概率几乎贴地飞行，到了某个年龄后会突然指数级拉升。衰老，是全球大多数人的死因本质，但目前没有一个国家或大型机构在系统性地拆解这个问题。LBF的路线图就是想补上这个“战略空白”。 Last Friday morning I sat in on a session by Eric, Head of Operations from Longevity Biotech Fellowship (LBF). Founded roughly three years ago, this nonprofit focuses on one ...
图 上周五上午听的是Longevity Biotech Fellowship（LBF）的运营负责人Eric Magro的分享。这个成立约三年的非营利组织专注一件事：把“解决衰老”当成一个值得立项、拨款、招人的工程问题来做。 Eric开场放了一张死亡率曲线。年轻时，我们的死亡概率几乎贴地飞行，到了某个年龄后会突然指数级拉升。衰老，是全球大多数人的死因本质，但目前没有一个国家或大型机构在系统性地拆解这个问题。LBF的路线图就是想补上这个“战略空白”。 Last Friday morning I sat in on a session by Eric, Head of Operations from Longevity Biotech Fellowship (LBF). Founded roughly three years ago, this nonprofit focuses on one thing: treating "solving aging" as an engineering problem worthy of formal project launch, funding, and hiring. Eric opened with a mortality curve. When we're young, the probability of death hovers near zero; after a certain age, it spikes exponentially. Aging is essentially the leading cause of death worldwide, yet no country or major institution is systematically dismantling the problem. LBF's roadmap aims to fill this strategic void. [ LBF把解题思路系统性地拆成三条（难度和资金需求依次递减）] 生物工程（Bioengineering） ：彻底理解衰老生物学并干预。Eric认为这是最难、最花钱、最遥远的方向，因为人类至今没有公认的衰老理论框架，连因果通路都没完全摸清。 生物停滞（Biostasis） ：在衰老被解决前，把人“暂停”。主要是低温保存（cryonics），也包括其他尚未成熟的技术。Eric强调这更像工程问题而非基础科学问题，且目前全球从业者极少、资金严重不足。 替换（Replacement） ： 哪里坏了换哪里，从细胞、组织、器官到全身替换。LBF认为这条路径的成本和时间预估远低于生物工程，因此他们最为之兴奋。 [LBF breaks the solution into three paths, ranked by difficulty and capital needs] Bioengineering — fully understanding and intervening in aging biology. Eric considers this the hardest, most expensive, and most distant route. Humanity still lacks a consensus theoretical framework for aging; we haven't even fully mapped the causal pathways. Biostasis — putting people "on pause" until aging is solved. Primarily cryonics, plus other immature tech. Eric stresses this is more engineering than basic science, but global practitioners are scarce and funding is severely lacking. Replacement — swapping out whatever breaks, from cells to tissues to organs to whole bodies. LBF estimates this path demands far less cost and time than bioengineering, which is why they're most excited about it. [一些技术节点性事件已经发生] 2018年，中国科学家完成世界首例灵长类动物体细胞克隆（“中中”、“华华”），成果发表于Cell，这...
Data from Stocktwits shows that retail sentiment has cooled slightly to ‘bullish’ on SPY and QQQ, signaling some caution after the market’s sharp AI-driven rally. Loading... Loading... Loading... Loading... Loading... Loading... Loading... Loading... Loading... Loading... Loading... Loading... Loading... Loading... Loading... Loading... Investors balanced hopes of a U.S.-Iran deal against fresh ge...
Data from Stocktwits shows that retail sentiment has cooled slightly to ‘bullish’ on SPY and QQQ, signaling some caution after the market’s sharp AI-driven rally. Loading... Loading... Loading... Loading... Loading... Loading... Loading... Loading... Loading... Loading... Loading... Loading... Loading... Loading... Loading... Loading... Investors balanced hopes of a U.S.-Iran deal against fresh geopolitical tensions. Reports emerged that U.S. forces conducted defensive strikes on Iranian missile launch sites and boats overnight. ‘The Big Short’ investor Michael Burry renewed his criticism of the AI boom over the weekend, warning that hyperscalers and chipmakers may be overextending themselves in what he called a “temporary” surge in demand. Later this week, cloud software company Snowflake and chipmaker Marvell Technology will report results. U.S. stock futures were higher early Tuesday as markets resumed trade after the Memorial Day holiday amid geopolitical developments in the Middle East. While President Donald Trump stated that negotiations to end the three-month war with Iran are "proceeding nicely," the optimism was heavily checked by news of fresh U.S. defensive air strikes against Iranian missile sites and boats. These reports have triggered volatility in oil markets, sending Brent crude soaring through Asian trade before a temporary retreat below $100 a barrel. Keep an eye on United States Oil Fund (USO) & Battalion Oil (BATL) in trade today. Read Next Loading... Loading... As of 4:30 a.m. ET on Tuesday: Dow and Nasdaq futures were 0.6% higher, S&P 500 futures gained 0.8%, and Russell 2000 futures were up 1%. Retail sentiment toward the SPDR S&P 500 ETF (SPY), an exchange-traded fund that tracks the S&P 500 Index, and the Invesco QQQ Trust (QQQ) ETF, which tracks the Nasdaq-100 Index, has moderated to ‘bullish’ from ‘extremely bullish’ last week. Trending Stocks To Watch Nvidia (NVDA) remains in the spotlight. CEO Jensen Huang has reportedly demanded tighte...
Investors balanced hopes of a U.S.-Iran deal against fresh geopolitical tensions. Reports emerged that U.S. forces conducted defensive strikes on Iranian missile launch sites and boats overnight. ‘The Big Short’ investor Michael Burry renewed his criticism of the AI boom over the weekend, warning that hyperscalers and chipmakers may be overextending themselves in what he called a “temporary” surge...
Investors balanced hopes of a U.S.-Iran deal against fresh geopolitical tensions. Reports emerged that U.S. forces conducted defensive strikes on Iranian missile launch sites and boats overnight. ‘The Big Short’ investor Michael Burry renewed his criticism of the AI boom over the weekend, warning that hyperscalers and chipmakers may be overextending themselves in what he called a “temporary” surge in demand. Later this week, cloud software company Snowflake and chipmaker Marvell Technology will report results. U.S. stock futures were higher early Tuesday as markets resumed trade after the Memorial Day holiday amid geopolitical developments in the Middle East. While President Donald Trump stated that negotiations to end the three-month war with Iran are "proceeding nicely," the optimism was heavily checked by news of fresh U.S. defensive air strikes against Iranian missile sites and boats. These reports have triggered volatility in oil markets, sending Brent crude soaring through Asian trade before a temporary retreat below $100 a barrel. Keep an eye on United States Oil Fund (USO) & Battalion Oil (BATL) in trade today. See what 10M+ investors are talking about. Get the Stocktwits Daily Rip for what retail is watching right now, free to your inbox As of 4:30 a.m. ET on Tuesday: Dow and Nasdaq futures were 0.6% higher, S&P 500 futures gained 0.8%, and Russell 2000 futures were up 1%. Retail sentiment toward the SPDR S&P 500 ETF (SPY), an exchange-traded fund that tracks the S&P 500 Index, and the Invesco QQQ Trust (QQQ) ETF, which tracks the Nasdaq-100 Index, has moderated to ‘bullish’ from ‘extremely bullish’ last week. Trending Stocks To Watch Nvidia (NVDA) remains in the spotlight. CEO Jensen Huang has reportedly demanded tighter compliance from supplier Super Micro Computer (SMCI) following fraud arrests in Taiwan, while "The Big Short" investor Michael Burry has again warned that Nvidia's current hyperscaler demand is only "temporary." Microsoft (MSFT), Meta Plat...
If you're trying to identify the best-performing stocks of this century, Netflix (NFLX 0.74%) should probably be on that list. Over the past two decades, the streaming stock has soared 22,050% (as of May 22). Netflix has clearly done things right from an operational and strategic perspective to deliver a remarkable performance like that. The business, which now sports a market capitalization of $3...
If you're trying to identify the best-performing stocks of this century, Netflix (NFLX 0.74%) should probably be on that list. Over the past two decades, the streaming stock has soared 22,050% (as of May 22). Netflix has clearly done things right from an operational and strategic perspective to deliver a remarkable performance like that. The business, which now sports a market capitalization of $373 billion, has certainly developed an economic moat. But is it the widest one in streaming? Scale is critical in streaming Netflix has experienced such rapid growth because it was early to the streaming race. People found it provided a drastically better experience than cable TV. As of Dec. 31, 2025, Netflix had over 325 million subscribers, up from 71 million paid members 10 years before. In 2026, management expects the company to report about $51 billion in revenue. This is a scaled operator, enabled by its first-mover advantage. That scale provides a cost advantage, which supports Netflix's moat. Unlike subscale peers, this business produces meaningful profits. Its operating margin was 32.3% in Q1 (ended March 31). And leadership's forecast calls for $12.5 billion in free cash flow for all of 2026. Plus, it's hard to underplay the brand. Netflix's name has become synonymous with streaming video. And it's often used as a verb, indicating robust consumer mind share. Scale is clearly a key component for streaming businesses to achieve profitability. Just look at Walt Disney, which is one of the few streamers that can be mentioned in the same breath as Netflix. For years, the House of Mouse was posting significant operating losses within its streaming segment, which is anchored by flagship service Disney+. Since the third quarter of fiscal 2024, the company's direct-to-consumer operations have generated ballooning profits. With higher revenue and a larger subscriber base that can absorb sizable content investments, the bottom line has exploded. Netflix's rival possesses a p...
Palantir attacks London mayor over cancelled policing technology deal Blocking the contract could undermine public safety, it says Palantir’s Louis Mosley has hit back after City Hall blocked a £50m contract. The row over AI and policing deepened on Friday after the US technology firm Palantir Technologies accused the Mayor of London, Sadiq Khan, of jeopardising public safety by blocking a £50m co...
Palantir attacks London mayor over cancelled policing technology deal Blocking the contract could undermine public safety, it says Palantir’s Louis Mosley has hit back after City Hall blocked a £50m contract. The row over AI and policing deepened on Friday after the US technology firm Palantir Technologies accused the Mayor of London, Sadiq Khan, of jeopardising public safety by blocking a £50m contract with the Metropolitan Police. The dispute centres on plans for Scotland Yard to expand its use of Palantir's software to analyse criminal intelligence and identify patterns in investigations. The deal was halted after City Hall officials concluded there had been a "clear and serious breach" of procurement rules. Officials in the mayor's office argued the tendering process may have unfairly favoured Palantir and failed to give rival suppliers a meaningful opportunity to compete for the contract. Louis Mosley, Palantir's head of UK and European operations, criticised the decision, accusing the mayor of allowing political considerations to interfere with policing. "What Londoners value is not being mugged, not being raped by a serving police officer," he told Times Radio. "If we are going to politicise procurement in that way then we are going to compromise public safety." Mosley’s comments prompted immediate criticism from Labour MP Stella Creasy, who said the executive "should be ashamed of himself" for invoking cases of sexual abuse involving police officers in defence of a commercial contract. "To hear the CEO of Palantir using the serious matter of sexual abuse by Met officers to attack the mayor of London for rejecting his company and so cutting his profits shows exactly why Palantir are not fit to lecture anyone on values," she said. Questions over Palantir's record The dispute has revived scrutiny of Palantir's wider international work. The company, co-founded by billionaire investor Peter Thiel, has contracts with the Israeli military and has supported immigrat...
The UK recorded its hottest ever day in May on Monday, with an all-time high of 34.8C recorded at London’s Kew Gardens. Temperatures above 33C were recorded across the south-east of England, while Wales also provisionally broke its May temperature record. The heat is expected to persist through the week, with a 35C peak forecast on Tuesday. We want to hear from you. How are you coping with the hea...
The UK recorded its hottest ever day in May on Monday, with an all-time high of 34.8C recorded at London’s Kew Gardens. Temperatures above 33C were recorded across the south-east of England, while Wales also provisionally broke its May temperature record. The heat is expected to persist through the week, with a 35C peak forecast on Tuesday. We want to hear from you. How are you coping with the heat this summer at work and at home? What impact has hot weather had on you? Have you been forced to make lifestyle changes recently to cope with the temperatures? Share your experience You can tell us your experience using this form. Please share your story if you are 18 or over, anonymously if you wish. For more information please see our terms of service and privacy policy Tell us here Your responses, which can be anonymous, are secure as the form is encrypted and only the Guardian has access to your contributions. We will only use the data you provide us for the purpose of the feature and we will delete any personal data when we no longer require it for this purpose. For alternative ways to get in touch securely please see our tips guide Name Where do you live? Tell us a bit about yourself (e.g. age, background, what you do) Optional How are you being affected by the heatwave? Please include as much detail as possible. If you are happy to, please upload a photo of yourself here Optional Please note, the maximum file size is 5.7 MB . Choose file Can we publish your response? Yes, entirely Yes, but contact me first Yes, but please keep me anonymous No, this is information only Phone number Optional Your contact details are helpful so we can contact you for more information. They will only be seen by the Guardian. Email address Your contact details are helpful so we can contact you for more information. They will only be seen by the Guardian. You can add more information here Optional If you include other people's names please ask them first. Would you be interested in speak...
The mother of a teenager who believes he died in a TikTok challenge gone wrong has said that Downing Street has been too slow to move towards a social media ban for under-16s, and accused the government of “kicking it down the road”. Ellen Roome, the mother of Jools Sweeney, 14, is among the families who will meet Keir Starmer on Tuesday as a consultation into the social media ban closes this week...
The mother of a teenager who believes he died in a TikTok challenge gone wrong has said that Downing Street has been too slow to move towards a social media ban for under-16s, and accused the government of “kicking it down the road”. Ellen Roome, the mother of Jools Sweeney, 14, is among the families who will meet Keir Starmer on Tuesday as a consultation into the social media ban closes this week. “Come on, get a grip, let’s actually stand up, do something, make a decision,” she said on Today on BBC Radio 4. “I don’t care if they take it away for adults and children until it’s safe, just take it away, fix it, and then we can give it back.” Roome said she hoped a ban would give technology companies the impetus to make the platforms safer. “They spend millions and billions of pounds on making their system. They could spend some money on actually fixing their system and say this is now a safe product, and give it back. But until it’s safe, I absolutely wholeheartedly say take it away.” Anna Turley, the Labour party chair, said the government would “seize this moment” but said it was right there had been time taken on the consultation. “We need to make sure that legislation and protection keeps pace with technology as it changes and protects our children going forward,” she added. “We’ve got legislation in place already to enable us to take these powers, so we’ll be acting as soon as possible because we need to make sure we protect children going forward and we get this right.” The former health secretary Wes Streeting, who compared social media to tobacco in a Guardian interview on Monday, told Today that the tech companies were to blame for making their products so addictive. “They know that it is harmful, and the business model is orientated towards getting kids, while they’re young, addicting them with the design features that are designed for addiction to grab your attention and keep you on their platform for as long as possible,” he said. He said there was “a gro...
Trumpeter Robyn Steward thought clubs weren’t for her until she encountered Fabric’s accessible upgrade – the new home for her radically inclusive, space-themed night Until May last year, trumpeter Robyn Steward had never been in a nightclub space, save for playing trumpet with Lancaster duo the Lovely Eggs at London’s Heaven, and a few nights in a university hall that doubled as a lunch room. Ste...
Trumpeter Robyn Steward thought clubs weren’t for her until she encountered Fabric’s accessible upgrade – the new home for her radically inclusive, space-themed night Until May last year, trumpeter Robyn Steward had never been in a nightclub space, save for playing trumpet with Lancaster duo the Lovely Eggs at London’s Heaven, and a few nights in a university hall that doubled as a lunch room. Steward is autistic and has multiple disabilities including cerebral palsy. “Sometimes strobes can trigger migraines for me, or feel a bit overwhelming,” she says. “I feel like my body’s a bit lost.” When she wanted to see a gig at Fabric nightclub in London, she asked a friend to go with her as a carer. “I was amazed at how accessible it was,” she says. Subtle touches integrate multiple access needs into the space. “The mezzanine level meant that I didn’t have the strobes in my face. There was a rail that I could hold on to, and there was seating opposite the balcony so I could sit and watch the gig.” She also noticed Fabric’s recently upgraded sensory dancefloor, which deliberately transforms sound into tactile vibrations to better cater for the hearing impaired. “I could see that the lights were strobing and everything, but I felt safe,” Steward says. Continue reading...
ToucanStudios London ( UKX ) +0.63% Germany ( DAX:IND ) -0.66% France ( CAC:IND ) -0.74% In other parts of Europe, producer price inflation in Spain spiked to 8.3% year-on-year in April 2026, the steepest since December 2022, from a downwardly revised 3.1% in the prior month. The pan-European Stoxx 600 ( STOXX) eased 0.2% on Tuesday as investors tracked developments in the Middle East and Ukraine ...
ToucanStudios London ( UKX ) +0.63% Germany ( DAX:IND ) -0.66% France ( CAC:IND ) -0.74% In other parts of Europe, producer price inflation in Spain spiked to 8.3% year-on-year in April 2026, the steepest since December 2022, from a downwardly revised 3.1% in the prior month. The pan-European Stoxx 600 ( STOXX) eased 0.2% on Tuesday as investors tracked developments in the Middle East and Ukraine amid renewed volatility in oil markets, following strong gains across the region’s major bourses in the previous session. On the geopolitical front, U.S. forces carried out what Central Command described as “self defense” strikes in southern Iran early Tuesday. Secretary of State Marco Rubio, who is in India, said that the Strait of Hormuz ultimately will have to be opened “one way or the other.” Investors are also closely monitoring events in the ongoing war in Ukraine, after Russia’s foreign minister Sergei Lavrov, told his U.S. counterpart, Marco Rubio, to evacuate diplomats and citizens from Kyiv ahead of fresh “systematic strikes” on the Ukrainian capital. In corporate news, shares of Ferrari ( RACE ) tumbled more than 6% after the luxury automaker introduced its first fully electric vehicle, the Ferrari Luce, on Tuesday. Meanwhile, Kingfisher ( KGFHF ) — the owner of U.K. home improvement chains B&Q and Screwfix—climbed to the top of the Stoxx 600 after reporting its first-quarter earnings update. In the bond market, the yield on the US 10-year Treasury was down 6 basis points to 4.51%. UK's 10-year yield was down 4 basis points to 4.86%. Germany's 10-year yield was up 3 basis points to 2.96%. Currencies: ( EUR:USD ) ( GBP:USD ) ( CHF:USD ) ETFs: (NYSEARCA: EWG ), (NYSE: GF ), (NYSEARCA: EWI ), (NYSEARCA: EWQ ), (NASDAQ: FGM ), (NASDAQ: DAX ), (NYSEARCA: FLGR ), (NYSEARCA: FXB ), (NYSEARCA: EWU ), (NASDAQ: FKU ), (BATS: EWUS ), (NYSEARCA: FLGB ), (NYSEARCA: GREK ) More on Europe, GREK: Stealthy YTD Gains Likely To Continue, Eyes On Banks A Final Path To Peace? Markets...