Oculis Holding ( OCS ) lost more than 20% on Friday after the company announced the failure of two late-stage trials assessing its lead candidate, OCS-01, for diabetic macular edema, a serious eye condition linked to diabetes. Citing topline data, the Swiss biopharma said its Phase 3 DIAMOND-1 and DIAMOND-2 trials didn’t meet the primary endpoint. As the primary goal, the two international trials ...
Oculis Holding ( OCS ) lost more than 20% on Friday after the company announced the failure of two late-stage trials assessing its lead candidate, OCS-01, for diabetic macular edema, a serious eye condition linked to diabetes. Citing topline data, the Swiss biopharma said its Phase 3 DIAMOND-1 and DIAMOND-2 trials didn’t meet the primary endpoint. As the primary goal, the two international trials involving more than 800 patients assessed the average 52-week change in the best-corrected visual acuity early treatment diabetic retinopathy study letter score (BCVA ETDRS) . The secondary endpoint, the percentage of patients with at least a 15-letter gain in BCVA post OCS-01 therapy, was also not met. However, there were no new safety signals, and OCS-01 eye drops indicated a tolerability profile consistent with its prior studies, according to Oculis (OCLS). Given the setback, the company said it will not seek an FDA filing for OCS-01 in DME and plans to initiate a strategic prioritization of resources. More on Oculis Holding Seeking Alpha’s Quant Rating on Oculis Holding Historical earnings data for Oculis Holding Financial information for Oculis Holding
"Closing The Nuclear Fuel Cycle" - Newcleo's $780M War Chest And Oklo Partnership Fuel $2.4B SPAC Debut It's open season in the nuclear industry for going public, and this week's episode features newcleo, a European lead-cooled reactor developer. The Paris-based developer of lead-cooled fast reactors (LFRs) and closed-cycle MOX fuel announced it will merge with NewHold Investment Corp III (ticker ...
"Closing The Nuclear Fuel Cycle" - Newcleo's $780M War Chest And Oklo Partnership Fuel $2.4B SPAC Debut It's open season in the nuclear industry for going public, and this week's episode features newcleo, a European lead-cooled reactor developer. The Paris-based developer of lead-cooled fast reactors (LFRs) and closed-cycle MOX fuel announced it will merge with NewHold Investment Corp III (ticker NHIC) in a deal valuing the company at roughly $2.4 billion . A $220 million oversubscribed PIPE at $10 per share plus up to $209 million from the SPAC trust should deliver as much as $429 million in gross proceeds before redemptions and fees. The combined entity expects to list on Nasdaq under ticker NWCL in the second half of 2026 . Hopefully their transition to public markets doesn't follow the same path as microreactor developer Hadron Energy… Founded by Stefano Buono (the man who took Advanced Accelerator Applications public on Nasdaq in 2015 and sold it to Novartis for $3.9 billion in 2018), Newcleo has already raised approximately $780 million privately across Europe. It generated roughly $80 million in revenue last year from its vertically integrated supply-chain subsidiaries while building a 900-plus employee team across seven countries and 16 offices. The technology: Newcleo’s 200 MW (electric) reactor uses liquid lead coolant . The company highlights that lead is cheap, high-boiling, and chemically inert with water and air. The lead is paired with proprietary MOX fuel (a mixture of uranium and plutonium) fabricated from reprocessed nuclear waste. Their target for commercial fuel manufacturing is 2031, and they hold a pipeline of 9.2 GW of advanced commercial opportunities, including a state-backed Slovak project for up to four 200 MWe units. As we recently covered, Oklo was selected by the Department of Energy for advanced negotiations under the Surplus Plutonium Utilization Program; one of five firms tapped to convert up to 20 metric tons of Cold War-era weapons...
With the DOJ expected to approve the $110 billion Hollywood megamerger, political concerns over turmoil at Paramount’s CBS may push Democratic AGs to act, experts say.
With the DOJ expected to approve the $110 billion Hollywood megamerger, political concerns over turmoil at Paramount’s CBS may push Democratic AGs to act, experts say.
This article first appeared on GuruFocus. Alphabet's (NASDAQ:GOOG) Waymo is moving further into the driverless ridehailing race with Ojai, a new autonomous vehicle built specifically for robotaxi service. The company said the vehicle will offer public rides in California and Arizona without human supervision, starting with select riders in San Francisco, Los Angeles and Phoenix. The move comes as ...
This article first appeared on GuruFocus. Alphabet's (NASDAQ:GOOG) Waymo is moving further into the driverless ridehailing race with Ojai, a new autonomous vehicle built specifically for robotaxi service. The company said the vehicle will offer public rides in California and Arizona without human supervision, starting with select riders in San Francisco, Los Angeles and Phoenix. The move comes as Waymo continues to lead the US market for paid driverless ridehailing, while Tesla (NASDAQ:TSLA) and Amazon's Zoox are beginning to push into the same space. The four-seat minivan is being developed with Zeekr, a unit of China-based Geely Automobile Holdings, through a partnership first announced in 2021. Waymo says the Ojai could improve both its economics and the rider experience versus retrofitted consumer vehicles, with a roomier cabin, flat floor, low step-in height and the latest generation of its autonomous driving system. Initial rides will be free as Waymo gathers feedback before adding more cities over time. The vehicle is designed in Sweden and built on an electric skateboard platform imported from China without self-driving or connectivity technology. Waymo will then integrate its autonomous driving system during final assembly at its Mesa, Arizona factory alongside Magna International, where the company said it is working to lift production to tens of thousands of vehicles per year. The rollout is focused on markets with more favorable weather and well-tested traffic conditions, after Waymo recently suspended service in multiple US cities when some vehicles drove into flooded roads.
IherPhoto/iStock via Getty Images I have highlighted the extreme valuations of the current market many, many times on these pages in recent quarters. Viewed from a historical lens, equities have only been priced this dearly once in U.S. history. That was during the tail end of the Internet Boom. By some metrics, the markets that are riding the AI wave are valued even more highly than during the la...
IherPhoto/iStock via Getty Images I have highlighted the extreme valuations of the current market many, many times on these pages in recent quarters. Viewed from a historical lens, equities have only been priced this dearly once in U.S. history. That was during the tail end of the Internet Boom. By some metrics, the markets that are riding the AI wave are valued even more highly than during the last technology paradigm shift at the end of the 20th century. AdvisorPerspectives.com However, to me the most intriguing part of the current market dynamics is the total divergence between equities and consumer sentiment. Especially given nearly 70% of economic activity in the U.S. is driven by consumers. Of note, 70% of GDP growth in Q1 was driven by AI-related activity due to the huge data centers that are being built across the nation. Zero Hedge In 1999, valuations were excessive, and the NASDAQ would lose 80% of its value from peak to trough during the ensuing Internet Bust. But at least economic growth was widespread and well dispersed in the late 1990s. GDP growth came in at four percent or better annually from 1996 to 1999. And this robust growth was reflected in consumer sentiment readings that hit all-time highs. TopDown Charts, LSEG The exact opposite is happening within this market. Equities are at all-time highs, and market concentration is past the extreme levels of the Internet Boom. However, consumer sentiment has reached all-time lows. In fact, consumer sentiment readings are at their lowest ebb since the University of Michigan began this monthly survey back in 1952. University of Michigan Investors should digest this for a minute. Consumers are more down in the dumps than they were during the worst of the Great Financial Crisis. Lower than the Vietnam War, below the brutal double-dip recession of 1980-1982, the OPEC embargo of 1973, and the Cuban Missile Crisis when the nation was on the brink of WWIII. Awealthofcommonsense.com So, why is consumer sentiment...
JUHTKONNA KOMMENTAAR PRFoodsi majandusaasta kolmas kvartal kulges jätkuvalt keerulises majanduskeskkonnas, mida mõjutasid nõrk tarbimine, hinnasurve ning ebakindlus nii Eesti kui ka lähiturgude jaekaubanduses. Juhtkond on keskendunud äritegevuse stabiliseerimisele ja kulubaasi kontrollile, kuid madalam müügimaht avaldas kvartali tulemustele märkimisväärset mõju.
JUHTKONNA KOMMENTAAR PRFoodsi majandusaasta kolmas kvartal kulges jätkuvalt keerulises majanduskeskkonnas, mida mõjutasid nõrk tarbimine, hinnasurve ning ebakindlus nii Eesti kui ka lähiturgude jaekaubanduses. Juhtkond on keskendunud äritegevuse stabiliseerimisele ja kulubaasi kontrollile, kuid madalam müügimaht avaldas kvartali tulemustele märkimisväärset mõju.
MANAGEMENT COMMENTARY PRFoods’ third quarter of the financial year continued to be affected by a challenging economic environment, characterised by weak consumer demand, price pressure and uncertainty in the retail sector both in Estonia and in neighbouring markets. Management has focused on stabilising operations and controlling the cost base, but lower sales volumes had a significant impact on t...
MANAGEMENT COMMENTARY PRFoods’ third quarter of the financial year continued to be affected by a challenging economic environment, characterised by weak consumer demand, price pressure and uncertainty in the retail sector both in Estonia and in neighbouring markets. Management has focused on stabilising operations and controlling the cost base, but lower sales volumes had a significant impact on the quarter’s results. Third‑quarter revenue amounted to EUR 3.2 million, a decrease of 14% compared to the same period last year. Gross profit declined to EUR 0.4 million, driven by lower production volumes and higher raw material prices. EBITDA for the quarter was EUR ‑0.3 million (Q3 2024/2025: EUR 0.7 million), and operating loss totalled EUR ‑0.5 million (Q3 2024/2025: EUR ‑0.3 million). The net loss for the quarter was EUR ‑0.9 million, compared to a net loss of EUR ‑0.5 million a year earlier. The increase in net loss was further amplified by higher finance costs arising from restructured debt obligations, which amounted to EUR 0.4 million during the quarter. Revenue for the first nine months reached EUR 11.9 million, a decrease of 21% year‑on‑year. Gross profit was EUR 2.1 million, 34% lower than in the same period last year, and nine‑month EBITDA amounted to EUR ‑0.5 million, compared to EUR 0.6 million in the previous year. Operating loss totalled EUR ‑0.8 million (9M 2024/2025: EUR 0.1 million), and net loss reached EUR ‑2.4 million (9M 2024/2025: EUR ‑0.9 million). The results were significantly affected by interest expenses related to restructured debt, which amounted to EUR 1.6 million over the nine‑month period. Geographically, the Group’s sales remained heavily concentrated in the United Kingdom. Revenue in the UK amounted to EUR 10.4 million, representing 87% of total sales. Sales in Estonia declined to EUR 1.5 million, a decrease of nearly 65% year‑on‑year, reflecting persistently weak consumer demand and pressure in the retail sector. The Group entered the...
You never know when your number is going to be called. That’s what I learned playing team sports as a kid. Though to be honest, my number was not often called. But I digress. For a couple of weeks during May, I was fortunate enough to be chosen by Barchart’s editors to fill the formidable shoes of Jim Van Meerten by writing this website’s regular Chart of the Day column. It was a temporary gig, a ...
You never know when your number is going to be called. That’s what I learned playing team sports as a kid. Though to be honest, my number was not often called. But I digress. For a couple of weeks during May, I was fortunate enough to be chosen by Barchart’s editors to fill the formidable shoes of Jim Van Meerten by writing this website’s regular Chart of the Day column. It was a temporary gig, a cameo role, and one which I am happy to be repeating later in June. As it turned out, going through that specific daily process of selecting one stock to highlight, and then detailing why, was a fantastic exercise in keeping my analytical gears greased. Oh, but it turned out to be much more than that for me. It turned into an intellectual lightning strike. I’ll explain why in a moment. But first, the easy part: I am now a Chart of the Day subscriber. It’s delivered right to my inbox every day at no cost. That was my easiest call of the month, because one of the first things you learn as an investment writer and analyst is to spot value-added content from your peers. I’d suggest you do the same (and only partly because when Jim takes a break from the action again in a couple of weeks, you’ll get to follow along with my next round of daily takes). Now, back to that lightning strike… The Benefits of Borrowing Jim’s Boxster (Proverbially) If you have followed my research here , and perhaps elsewhere, you know where my head has been. I have spent decades focused on macro risk, asset allocation, and helping self-directed investors survive a market that frequently feels unhinged. As a result, I tend to look at the investing world from 30,000 feet. But with Jim enjoying a well-deserved sabbatical from his daily chart duties, I was now forcing myself to sit down every single morning, scan thousands of symbols, select one specific stock chart, and defend it to Barchart’s sharp public audience. That process did something unexpected. It broke through my own macro fog and completely re-...
Key Points Alphabet's advertising business was responsible for 80% of the company's first-quarter revenue. The cloud computing division has a backlog of $462 billion, with half of that to be converted to revenue in the next two years. 10 stocks we like better than Alphabet › If there were any doubts, they are certainly put to rest by now. Artificial intelligence (AI) stocks have legitimate staying...
Key Points Alphabet's advertising business was responsible for 80% of the company's first-quarter revenue. The cloud computing division has a backlog of $462 billion, with half of that to be converted to revenue in the next two years. 10 stocks we like better than Alphabet › If there were any doubts, they are certainly put to rest by now. Artificial intelligence (AI) stocks have legitimate staying power and appear destined to be one of the biggest long-term drivers in the stock market for the next several years. Not even a first-quarter swoon in AI stocks has derailed the market rally. The Nasdaq CTA Artificial Intelligence Index, which tracks the performance of companies involved with AI in the tech, industrial, medical, and other economic sectors, is up nearly 40% this year -- with 30% of that gain coming in the last 90 days. Will AI create the world's first trillionaire? Our team just released a report on the one little-known company, called an "Indispensable Monopoly" providing the critical technology Nvidia and Intel both need. Continue » I've been bullish on the tech sector and AI opportunities for several years. And as I look at the sector and seek stocks with a strong growth trajectory that also fit my buy-and-hold philosophy, there's one name that stands out as perhaps the best long-term opportunity in the AI space. That company is Alphabet (NASDAQ: GOOG) (NASDAQ: GOOGL). Here are two reasons why. 1. Alphabet's dominant core business For everything that Alphabet is involved in -- YouTube, the Android operating system, Waymo robotaxis, and more -- Alphabet's roots are in advertising. And that's the engine that funds Alphabet's AI ambitions. Alphabet's revenue in the first quarter was $109.89 billion, up 22% from a year ago. And most of that money came directly from advertising. Segment Q1 2026 Revenue Increase (YOY) Google Search and other $60.39 billion 19.1% YouTube ads $9.88 billion 10.7% Google Network $6.97 billion (3.9%) Total Google advertising $77.25...
(RTTNews) - After coming under pressure during an abbreviated holiday session last Friday, treasuries showed a lack of direction during trading on Monday. Bond prices spent much of the session lingering near the unchanged line. Subsequently, the yield on the benchmark ten-year note, which moves opposite of its price, crept up by less than a basis point to 3.415 percent. The choppy trading on the d...
(RTTNews) - After coming under pressure during an abbreviated holiday session last Friday, treasuries showed a lack of direction during trading on Monday. Bond prices spent much of the session lingering near the unchanged line. Subsequently, the yield on the benchmark ten-year note, which moves opposite of its price, crept up by less than a basis point to 3.415 percent. The choppy trading on the day came after treasuries fell sharply in the previous session following the release of the Labor Department's closely watched monthly jobs report. The report said non-farm payroll employment climbed by 236,000 jobs in March after jumping by an upwardly revised 326,000 jobs in February. Economists had expected employment to rise by about 240,000 jobs compared to the addition of 311,000 jobs originally reported for the previous month. Meanwhile, the Labor Department said the unemployment rate edged down to 3.5 percent in March from 3.6 percent in February. The unemployment rate was expected to be unchanged. On the heels of the report, CME Group's FedWatch Tool is currently indicating a 71.7 percent chance the Federal Reserve will raise interest rates by a quarter point next month. Traders were also looking ahead to key inflation data later in the week along with reports on retail sales and industrial production as well as the minutes of the latest Federal Reserve meeting. A lack of major U.S. economic data may lead to choppy trading on Tuesday, as traders look ahead to the release of key data later in the week. The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.
Woo Jin Ho, Bloomberg Intelligence Senior Hardware and Networking Analyst, says "in terms of scale" he would put his money on Dell. Dell shares surged the most in two years on Friday after the hardware maker gave an outlook for annual sales that far surpassed analysts’ estimates, fueled by demand for servers that power artificial intelligence work. (Source: Bloomberg)
Woo Jin Ho, Bloomberg Intelligence Senior Hardware and Networking Analyst, says "in terms of scale" he would put his money on Dell. Dell shares surged the most in two years on Friday after the hardware maker gave an outlook for annual sales that far surpassed analysts’ estimates, fueled by demand for servers that power artificial intelligence work. (Source: Bloomberg)
美國及古巴軍方高層罕有會面 To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video 【有線新聞】美國南方司令部司令和古巴軍方高層官員會面。 南方司令部司令多諾萬罕有前往古巴關塔那摩灣的美軍基地，和古巴武裝部隊總參謀長索托隆等高層會面，...
美國及古巴軍方高層罕有會面 To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video 【有線新聞】美國南方司令部司令和古巴軍方高層官員會面。 南方司令部司令多諾萬罕有前往古巴關塔那摩灣的美軍基地，和古巴武裝部隊總參謀長索托隆等高層會面，短暫交流軍事行動安全議題。多諾萬亦評估基地安全狀況，並和駐軍交流。古巴武裝部隊指今次會談是在雙方同意下舉行，會面氣氛積極，兩軍同意繼續保持溝通。 美國總統特朗普近期加強對古巴施壓，威脅推動政權更替，同時又派中情局局長拉特克利夫等官員和古巴官員談判。
Yagi Studio/DigitalVision via Getty Images The Defiance Drone and Modern Warfare ETF ( JEDI ) is beating the classic industrial ETFs in the defense and aerospace sector. How is that possible? I asked myself. After all, the sector is the same. Yet in the construction method of this ETF, there is a particular mechanism that has made it even more "high-beta" compared to its sector. And considering th...
Yagi Studio/DigitalVision via Getty Images The Defiance Drone and Modern Warfare ETF ( JEDI ) is beating the classic industrial ETFs in the defense and aerospace sector. How is that possible? I asked myself. After all, the sector is the same. Yet in the construction method of this ETF, there is a particular mechanism that has made it even more "high-beta" compared to its sector. And considering the ongoing catalysts, in the last quarter strong inflows came into JEDI. That said, in these sectors, there is, in my opinion, a strategy with which it's better to move. Obviously a personal opinion, but it has often helped me manage high-beta sector ETFs like JEDI. But before talking about it… What Is JEDI? JEDI is a passive ETF (indexing approach) with a sector theme that launched on September 25, 2025, with an expense ratio of 0.69% per year. The fund follows the BITA Drone and Modern Warfare Select Index with full physical replication and semi-annual rebalancing frequency with a special rule on IPOs and companies that "pivot" toward modern defense; considering the high degree of innovation, these can be added at any time, with only two business days' notice. JEDI - profile (Seeking Alpha) The index, and therefore the ETF, gives exposure to global companies in developed markets that derive at least 50% of revenues from the drone and modern warfare sector. Super interesting is the fact that the strategy explicitly excludes traditional defense (conventional weapons, armored vehicles, logistical aircraft). In theory, this makes it a truly distinctive contributor in a portfolio. The price return performance compared to defense-oriented solutions like ITA demonstrates it. JEDI - price return (Seeking Alpha) It must be said that the fund immediately captured attention because in about eight months after inception, AUM multiplied by nearly 7x, especially with the outbreak of the conflict in the Middle East. JEDI - S&P 500: total return (Seeking Alpha) But What's Inside? An unusu...