Almost as soon as researchers started exploring the capabilities of the CRISPR/Cas9 system, they recognized its potential use in targeted gene editing. But the intervening decades have seen slow progress as people worked to determine how to do so in a way that would be safe for use in humans. It was only a little over two years ago, decades after CRISPR's discovery, that the FDA approved the first...
Almost as soon as researchers started exploring the capabilities of the CRISPR/Cas9 system, they recognized its potential use in targeted gene editing. But the intervening decades have seen slow progress as people worked to determine how to do so in a way that would be safe for use in humans. It was only a little over two years ago, decades after CRISPR's discovery, that the FDA approved the first CRISPR-based therapy , for sickle-cell anemia. Now, following up on that success, a large Chinese collaboration has followed up with a description of an improved gene editing system that produces more focused changes and fewer mistakes. And they've used it to produce a therapy that addresses a disease that's closely related to sickle-cell anemia: β-Thalassaemia. Gene editing and its limits The CRISPR/Cas-9 system provides bacteria with a form of immunity. It uses specially structured RNAs (called guide RNAs) that can base-pair with a targeted sequence. The Cas-9 protein then recognizes this structure and cuts the DNA nearby. This is quite effective when the guide RNA can base-pair with a DNA virus, as the resulting cut will inactivate the virus. Read full article Comments
Comprehensive cross-platform coverage of the U.S. market close on Bloomberg Television, Bloomberg Radio, and YouTube with Romaine Bostick, Katie Greifeld, Carol Massar and Tim Stenovec. (Source: Bloomberg)
Comprehensive cross-platform coverage of the U.S. market close on Bloomberg Television, Bloomberg Radio, and YouTube with Romaine Bostick, Katie Greifeld, Carol Massar and Tim Stenovec. (Source: Bloomberg)
BayCom Corp. ( BCML ), the holding company for United Business Bank, announced on Thursday that its Board of Directors (the “Board”) has approved a leadership transition and appointed three new executives to execute the company's next phase of growth. The company has appointed Christopher F. Baron as president and chief executive officer of the company and the bank. Additionally, the board has app...
BayCom Corp. ( BCML ), the holding company for United Business Bank, announced on Thursday that its Board of Directors (the “Board”) has approved a leadership transition and appointed three new executives to execute the company's next phase of growth. The company has appointed Christopher F. Baron as president and chief executive officer of the company and the bank. Additionally, the board has appointed Kevin L. Thompson as executive vice president and chief financial officer of the company and the bank. The board has also appointed William J. Black , Jr., as executive vice chairman of the Company and the bank. In connection with the management transition, George J. Guarini , Janet L. King and Keary L. Colwell have each tendered their resignations from the board of directors of the company, effective April 10, 2026. The company’s board has approved the appointments of Baron and Black as members of the board, each effective as of April 13, 2026. Lloyd W. Kendall , Jr., will continue to serve as chair and William J. Black , Jr., will serve as executive vice chair. Source: Press Release More on Bay Commercial Bank Seeking Alpha’s Quant Rating on Bay Commercial Bank Historical earnings data for Bay Commercial Bank Dividend scorecard for Bay Commercial Bank Financial information for Bay Commercial Bank
vadimrysev/iStock via Getty Images Why the petrodollar is at risk When in 1971 the Bretton Woods system collapsed, the US was looking for new ways to keep the world relying on the US Dollar. The latter was no longer backed by gold, so it was necessary to find new influential allies able to preserve the US Dollar status across the world. Why not GCC countries? Back in 1970s, the GCC (Gulf Cooperati...
vadimrysev/iStock via Getty Images Why the petrodollar is at risk When in 1971 the Bretton Woods system collapsed, the US was looking for new ways to keep the world relying on the US Dollar. The latter was no longer backed by gold, so it was necessary to find new influential allies able to preserve the US Dollar status across the world. Why not GCC countries? Back in 1970s, the GCC (Gulf Cooperation Council) countries had already recognized how influential they were in the global economy, in fact they held the majority of world’s easy-to-reach oil. However, the GCC countries found themselves in a peculiar situation: selling oil made them rich on paper, but their cities didn’t reflect that richness. There were no advanced infrastructures, no high-quality hospitals and innovating companies. This is not a surprise, after all, they went from extreme poverty to extreme richness in a couple of decades, just because they were sitting on the most profitable soil in the world without even knowing it. In other words, the GCC had the raw material, but they lacked the human expertise to exploit their wealth. Guess who was willing to share its expertise in exchange of that raw material? Obviously, the US, a major net oil importer in 1970s. Chart made by the author, US Energy Information Administration data The US had all the incentive to make GCC a close ally, but it went even further. The US acknowledged that GCC would have become the backbone of the future global economy, in fact they had all the cards in their favor: a strategic position in the middle of the world, halfway between the West and the East, on top of having access to main global maritime routes through the Strait of Bab al Mandeb and the Strait of Hormuz. Basically, they possess the most important commodity and also the perfect way to deliver it. GCC countries were meant to be among the greatest powers in the world, and the US was smart enough to benefit from their ascent through the Petrodollar agreement. Here i...
In trading on Thursday, shares of the First Trust Financials AlphaDEX Fund ETF (Symbol: FXO) crossed above their 200 day moving average of $58.59, changing hands as high as $59.01 per share. First Trust Financials AlphaDEX Fund shares are currently trading up about 0.8% on the
In trading on Thursday, shares of the First Trust Financials AlphaDEX Fund ETF (Symbol: FXO) crossed above their 200 day moving average of $58.59, changing hands as high as $59.01 per share. First Trust Financials AlphaDEX Fund shares are currently trading up about 0.8% on the
Intel stock has been on an incredible run and the gains just keep on coming. The chip company’s stellar streak was under threat early Thursday until it announced a multiyear collaboration with Google to advance the next generation of artificial intelligence and cloud infrastructure. Essentially, the Alphabet owner will keep using Intel’s chips.
Intel stock has been on an incredible run and the gains just keep on coming. The chip company’s stellar streak was under threat early Thursday until it announced a multiyear collaboration with Google to advance the next generation of artificial intelligence and cloud infrastructure. Essentially, the Alphabet owner will keep using Intel’s chips.
In trading on Thursday, shares of Morgan Stanley's Depositary Shares RPRSTG 6.625% Non-Cumulative Preferred Stock, Series Q (Symbol: MS.PRQ) were yielding above the 6.5% mark based on its quarterly dividend (annualized to $1.6563), with shares changing hands as low as $25.48 on
In trading on Thursday, shares of Morgan Stanley's Depositary Shares RPRSTG 6.625% Non-Cumulative Preferred Stock, Series Q (Symbol: MS.PRQ) were yielding above the 6.5% mark based on its quarterly dividend (annualized to $1.6563), with shares changing hands as low as $25.48 on
Shares of StubHub (NYSE: STUB) fell as much as 9.7% on Thursday, before recovering to just a 3.1% decline by the end of the day's trading. StubHub had already had a rough go of it in its short time as a public company, beginning the day at $6.36 per share -- a far cry from its $23.50 IPO price last September. However, things went from tough to worse, as the Federal Trade Commission announced it wa...
Shares of StubHub (NYSE: STUB) fell as much as 9.7% on Thursday, before recovering to just a 3.1% decline by the end of the day's trading. StubHub had already had a rough go of it in its short time as a public company, beginning the day at $6.36 per share -- a far cry from its $23.50 IPO price last September. However, things went from tough to worse, as the Federal Trade Commission announced it was filing a lawsuit against the company, charging StubHub with violating the agency's "all-in" pricing initiative, which went into effect May 12, 2025. Continue reading
Among the underlying components of the Russell 3000 index, we saw noteworthy options trading volume today in Intuit Inc (Symbol: INTU), where a total of 15,526 contracts have traded so far, representing approximately 1.6 million underlying shares. That amounts to about 54.4% of
Among the underlying components of the Russell 3000 index, we saw noteworthy options trading volume today in Intuit Inc (Symbol: INTU), where a total of 15,526 contracts have traded so far, representing approximately 1.6 million underlying shares. That amounts to about 54.4% of
In trading on Thursday, shares of the ENPX ETF (Symbol: ENPX) entered into oversold territory, changing hands as low as $11 per share. We define oversold territory using the Relative Strength Index, or RSI, which is a technical analysis indicator used to measure momentum on a s
In trading on Thursday, shares of the ENPX ETF (Symbol: ENPX) entered into oversold territory, changing hands as low as $11 per share. We define oversold territory using the Relative Strength Index, or RSI, which is a technical analysis indicator used to measure momentum on a s
In trading on Thursday, shares of Edwards Lifesciences Corp (Symbol: EW) crossed below their 200 day moving average of $80.75, changing hands as low as $79.06 per share. Edwards Lifesciences Corp shares are currently trading off about 2.9% on the day. The chart below shows the
In trading on Thursday, shares of Edwards Lifesciences Corp (Symbol: EW) crossed below their 200 day moving average of $80.75, changing hands as low as $79.06 per share. Edwards Lifesciences Corp shares are currently trading off about 2.9% on the day. The chart below shows the
In trading on Thursday, shares of the Direxion Daily AMZN Bear 1X Shares ETF (Symbol: AMZD) entered into oversold territory, changing hands as low as $9.77 per share. We define oversold territory using the Relative Strength Index, or RSI, which is a technical analysis indicator
In trading on Thursday, shares of the Direxion Daily AMZN Bear 1X Shares ETF (Symbol: AMZD) entered into oversold territory, changing hands as low as $9.77 per share. We define oversold territory using the Relative Strength Index, or RSI, which is a technical analysis indicator
In trading on Thursday, shares of Teradata Corp (Symbol: TDC) crossed below their 200 day moving average of $25.46, changing hands as low as $24.77 per share. Teradata Corp shares are currently trading down about 3.1% on the day. The chart below shows the one year performance
In trading on Thursday, shares of Teradata Corp (Symbol: TDC) crossed below their 200 day moving average of $25.46, changing hands as low as $24.77 per share. Teradata Corp shares are currently trading down about 3.1% on the day. The chart below shows the one year performance
In trading on Thursday, shares of Dick's Sporting Goods, Inc (Symbol: DKS) crossed above their 200 day moving average of $211.99, changing hands as high as $212.74 per share. Dick's Sporting Goods, Inc shares are currently trading up about 3.8% on the day. The chart below show
In trading on Thursday, shares of Dick's Sporting Goods, Inc (Symbol: DKS) crossed above their 200 day moving average of $211.99, changing hands as high as $212.74 per share. Dick's Sporting Goods, Inc shares are currently trading up about 3.8% on the day. The chart below show
Among the underlying components of the Russell 3000 index, we saw noteworthy options trading volume today in EOS Energy Enterprises Inc (Symbol: EOSE), where a total of 138,878 contracts have traded so far, representing approximately 13.9 million underlying shares. That amounts
Among the underlying components of the Russell 3000 index, we saw noteworthy options trading volume today in EOS Energy Enterprises Inc (Symbol: EOSE), where a total of 138,878 contracts have traded so far, representing approximately 13.9 million underlying shares. That amounts
Looking at options trading activity among components of the Russell 3000 index, there is noteworthy activity today in Marathon Digital Holdings Inc (Symbol: MARA), where a total volume of 285,539 contracts has been traded thus far today, a contract volume which is representative
Looking at options trading activity among components of the Russell 3000 index, there is noteworthy activity today in Marathon Digital Holdings Inc (Symbol: MARA), where a total volume of 285,539 contracts has been traded thus far today, a contract volume which is representative
Looking at options trading activity among components of the Russell 3000 index, there is noteworthy activity today in Bloom Energy Corp (Symbol: BE), where a total volume of 64,197 contracts has been traded thus far today, a contract volume which is representative of approximate
Looking at options trading activity among components of the Russell 3000 index, there is noteworthy activity today in Bloom Energy Corp (Symbol: BE), where a total volume of 64,197 contracts has been traded thus far today, a contract volume which is representative of approximate
Kremlin proposes 32-hour ceasefire starting on Saturday afternoon – with Ukraine expected to agree to plan Vladimir Putin has declared a 32-hour ceasefire in Ukraine over the Orthodox Easter weekend, after an earlier call from Volodymyr Zelenskyy for a pause. The president’s decree, released by the Kremlin on Thursday, orders Russian forces to observe a ceasefire starting on 4pm Saturday and lasti...
Kremlin proposes 32-hour ceasefire starting on Saturday afternoon – with Ukraine expected to agree to plan Vladimir Putin has declared a 32-hour ceasefire in Ukraine over the Orthodox Easter weekend, after an earlier call from Volodymyr Zelenskyy for a pause. The president’s decree, released by the Kremlin on Thursday, orders Russian forces to observe a ceasefire starting on 4pm Saturday and lasting until the end of Sunday. Continue reading...
TriNet ( TNET ) ( NYSE: TNET ) on Thursday said it has agreed to acquire leave management technology provider Cocoon, in a deal aimed at strengthening its services for small and medium-sized businesses. Cocoon will add a compliance-focused leave of absence platform with automated workflows and AI-enabled capabilities to TriNet’s offerings. The transaction is expected to close this month, subject t...
TriNet ( TNET ) ( NYSE: TNET ) on Thursday said it has agreed to acquire leave management technology provider Cocoon, in a deal aimed at strengthening its services for small and medium-sized businesses. Cocoon will add a compliance-focused leave of absence platform with automated workflows and AI-enabled capabilities to TriNet’s offerings. The transaction is expected to close this month, subject to customary conditions and regulatory approvals. Financial terms were not disclosed, and TriNet said the deal is not expected to materially impact its 2026 financial guidance. Source: Press Release More on TriNet TriNet Group, Inc. (TNET) Q4 2025 Earnings Call Transcript Small-Cap industrial stocks ranked by quant ratings after earnings season Top 10 mid-cap industrial stocks ranked by lowest RSI Seeking Alpha’s Quant Rating on TriNet Historical earnings data for TriNet
Italian Prime Minister Giorgia Meloni ousted the chief executive officer of Leonardo SpA , the state-backed aerospace and defense contractor, while retaining CEOs at energy firms Eni SpA and Enel SpA . Leonardo CEO Roberto Cingolani will be replaced by Lorenzo Mariani , a senior executive at missile-maker MBDA Missile Systems Services SAS , Italy’s Finance Ministry said late Thursday. The governme...
Italian Prime Minister Giorgia Meloni ousted the chief executive officer of Leonardo SpA , the state-backed aerospace and defense contractor, while retaining CEOs at energy firms Eni SpA and Enel SpA . Leonardo CEO Roberto Cingolani will be replaced by Lorenzo Mariani , a senior executive at missile-maker MBDA Missile Systems Services SAS , Italy’s Finance Ministry said late Thursday. The government renewed the terms of Eni CEO Claudio Descalzi and Enel’s Flavio Cattaneo for another three years. Meloni is recalibrating leadership at state-controlled firms ahead of a re-election campaign set to take place by the end of next year. A polling setback last month weakened the premier and prompted changes in her cabinet, heightening attention on the round of executive appointments. Cingolani’s departure, after a turnaround at Leonardo that’s been welcomed by investors, underscores the pressure on Meloni to reassert power after the referendum on judicial reform she supported was soundly rejected at the polls. Opponents had urged voters to show their dissatisfaction with her leadership, and the outcome weakened the premier politically. Read More: Italy’s Meloni Vows to Govern Until End of Five-Year Mandate Italy owns significant stakes in a number of public and non-public companies considered strategic to the country’s security interests. The government exerts control through board majorities and proposes the CEOs on a three-year cycle. Its nominations require shareholder approvals. Poste Italiane SpA CEO Matteo Del Fante was nominated for a fourth term on April 2. Leonardo Turnaround Cingolani, 64, was appointed in 2023 by Meloni, and his position was initially seen as safe as his term came up for renewal. The former government minister presided over a 28% increase in revenue from 2023 to 2025, and the stock has risen fivefold as he repositioned Leonardo as a consolidator in the fast-changing European defense sector. People who have worked with him have described Cingolani ...