Rasi Bhadramani/iStock via Getty Images The Thesis Palisade Bio, Inc. ( PALI ) is an early-stage biotechnology company focused on developing a new class of PDE4 inhibitor prodrugs. Their lead asset, PALI-2108, recently received IND clearance and is set to initiate a Global Phase 2 ASCENTRA-UC Study in Ulcerative Colitis (UC), with the trial expected to commence in Q3 2026. In the completed Phase 1...
Rasi Bhadramani/iStock via Getty Images The Thesis Palisade Bio, Inc. ( PALI ) is an early-stage biotechnology company focused on developing a new class of PDE4 inhibitor prodrugs. Their lead asset, PALI-2108, recently received IND clearance and is set to initiate a Global Phase 2 ASCENTRA-UC Study in Ulcerative Colitis (UC), with the trial expected to commence in Q3 2026. In the completed Phase 1a/b trial, Palisade reported positive data featuring a favorable safety and tolerability profile, evidence of target engagement in ileal and colon tissue, and early signals of clinical activity in Crohn’s disease (CD). Furthermore, their balance sheet is sufficient to fund operations through the Phase 2 primary efficacy readouts for PALI-2108: specifically, for UC in the second half of 2027, and for CD in early 2028. As of the first quarter, Palisade held cash and cash equivalents of $132.6 million. What makes Palisade worth analyzing is its unique addition to the standard Mechanism of Action (MoA). Compared to other UC drugs like mufemilast , PALI-2108 restricts the PDE4 inhibitor to the gut to enable localized action. Ideally, this targeted approach could lead to fewer systemic side effects and greater efficacy. Why Now Is The Right Time Palisade is initiating its Global Phase 2 UC study in the coming weeks. The company is currently valued at a market cap of around $365 million; with $132.6 million in cash and no debt, its Enterprise Value (EV) sits at roughly $232.4 million. Looking at recent history, other early-stage UC companies with a differentiated MoA have held massive valuations. For instance, MORF reached a ~$3.1 billion valuation on the back of just an open-label Phase 2a study with a small patient cohort. Palisade expects its Phase 2 primary efficacy readout in early 2028, which could place the company on the same trajectory MORF was at its peak valuation. Success is entirely dependent on Palisade proving its unique MoA in larger trials, but the early clinical ...
Vancouver, BC, Canada, July 10, 2026 (GLOBE NEWSWIRE) -- Global Power Solutions Corp. (TSX Venture Exchange: PWER; Frankfurt Stock Exchanges: NJA) (“Global Power” or the “Company”) is pleased to announce that the Company has registered and will be in attendance at the Data Centre West 2026 (“Data Centre West”) conference, taking place September 9, 2026 at the Hyatt Regency in downtown Calgary, Alb...
Vancouver, BC, Canada, July 10, 2026 (GLOBE NEWSWIRE) -- Global Power Solutions Corp. (TSX Venture Exchange: PWER; Frankfurt Stock Exchanges: NJA) (“Global Power” or the “Company”) is pleased to announce that the Company has registered and will be in attendance at the Data Centre West 2026 (“Data Centre West”) conference, taking place September 9, 2026 at the Hyatt Regency in downtown Calgary, Alberta. Figure 1. Data Centre West – Learn more here Data Centre West is one of Western Canada’s leadi
India’s largest power producer is seeking to invest in overseas uranium mines to secure supplies needed to fuel 30 gigawatts of nuclear power capacity it plans to build over the next two decades. State-controlled NTPC Ltd. issued a tender to appoint consultants that will help identify potential assets in uranium-mining countries including Canada, Australia, Kazakhstan and South Africa, according t...
India’s largest power producer is seeking to invest in overseas uranium mines to secure supplies needed to fuel 30 gigawatts of nuclear power capacity it plans to build over the next two decades. State-controlled NTPC Ltd. issued a tender to appoint consultants that will help identify potential assets in uranium-mining countries including Canada, Australia, Kazakhstan and South Africa, according to documents posted on its tender website. Bids are due July 16. The search for uranium marks the latest step in India’s ambition to grow atomic power capacity more than elevenfold by 2047, part of a broader push to decarbonize an economy that’s driven largely by coal and other fossil fuels. NTPC aims to build around 30% of the country’s 100-gigawatt target. In December, the Indian parliament passed a law that will end a decades-old state monopoly in atomic power generation and open the industry up to private firms. The new legislation also envisages sweeping changes to the country’s liability provisions that had spooked investors. Read More: India Overhauls Nuclear Law to Allow Private Investment “The scale of planned capacity addition necessitates securing a sustainable fuel supply of uranium,” NTPC said in the bid document. “Considering the limitations of domestic fuel and mining reserves, overseas exploration and the acquisition of uranium mines are required.” At present, India relies on another state-controlled company – Uranium Corp. of India – for domestic supplies of the metal. The country’s only producer mines mainly in the states of Jharkhand and Andhra Pradesh. New Delhi has already been diversifying its overseas supplies, agreeing during Prime Minister Narendra Modi’s visit to Melbourne this week to import uranium from Australia . India also buys the atomic mineral from Uzbekistan and Russia, while shipments from Canadian miner Cameco Corp. are due to begin next year. Global uranium mining is relatively concentrated, with the top five producers accounting for alm...
格隆汇7月10日|有投资者在互动平台向首都在线提问,请问公司有多少数据中心?多少机柜啊?算力涨价对公司业绩有积极影响吗?首都在线回复称,目前公司在全球范围内运营数据中心节点,覆盖美洲、欧洲、亚太三大核心区域,已形成全球化算力服务网络。自建数据中心方面,公司聚焦张家口、芜湖、文昌及海外达拉斯等 AI 算力枢纽节点,布局高功率自建 AIDC,支撑大规模智算集群部署。 随着 AI 应用加速落地,算力需求...
格隆汇7月10日|有投资者在互动平台向首都在线提问,请问公司有多少数据中心?多少机柜啊?算力涨价对公司业绩有积极影响吗?首都在线回复称,目前公司在全球范围内运营数据中心节点,覆盖美洲、欧洲、亚太三大核心区域,已形成全球化算力服务网络。自建数据中心方面,公司聚焦张家口、芜湖、文昌及海外达拉斯等 AI 算力枢纽节点,布局高功率自建 AIDC,支撑大规模智算集群部署。 随着 AI 应用加速落地,算力需求持续增长,算力市场供需格局持续改善。公司凭借规模化GPU算力储备与成熟的交付能力,将充分受益于行业红利,智算业务将成为公司业绩修复的重要支撑。
The attacking players spent two years together at BVB, forming a friendship on their way to the very top This World Cup has been about the biggest names from the beginning but as Miami welcomes back its new favourite sporting pleasure on Saturday night, the man in with a shout of the Ballon d’Or probably won’t be the headline. With apologies to Harry Kane, in a football world moving past its two-d...
The attacking players spent two years together at BVB, forming a friendship on their way to the very top This World Cup has been about the biggest names from the beginning but as Miami welcomes back its new favourite sporting pleasure on Saturday night, the man in with a shout of the Ballon d’Or probably won’t be the headline. With apologies to Harry Kane, in a football world moving past its two-decades-long domination by the Lionel Messi/Cristiano Ronaldo duopoly, a pair of younger world-class stars will be drawing the majority of the glare as England take on Norway. Jude Bellingham and Erling Haaland have met regularly in the Champions League for Real Madrid and Manchester City over the past three years, but this is different. Their first encounter at international level is news in the front pages of the tabloids and gossip mags alike, Hello! running a feature entitled “Inside Jude Bellingham and Erling Haaland’s unlikely friendship before fierce Fifa showdown” before Saturday’s World Cup quarter-final in Florida. If Bellingham and Haaland were the game’s next superstar rivalry in the years to come (again, with apologies to Kylian Mbappé and Lamine Yamal) they would define the competition in starkly different parameters to their Argentinian and Portuguese predecessors. Continue reading...
Jayèma on working with England stars, a new look for Raphinha and forging a friendship with Lamine Yamal’s family Jayèma has had a World Cup like no other. Who else but the London hair stylist has worked with footballers from England, Brazil, the United States and Canada, and hung out with Lamine Yamal and his family, while having no idea who Lionel Messi is until recently? Who else but Jayèma has...
Jayèma on working with England stars, a new look for Raphinha and forging a friendship with Lamine Yamal’s family Jayèma has had a World Cup like no other. Who else but the London hair stylist has worked with footballers from England, Brazil, the United States and Canada, and hung out with Lamine Yamal and his family, while having no idea who Lionel Messi is until recently? Who else but Jayèma has been to her first game of men’s football and left before the end of a tumultuous match between Mexico and England at the Azteca Stadium because the atmosphere was too “rowdy”? Who else has made so many footballers feel especially good about their hair and themselves, but the hardest-working stylist and male groomer in elite sport? Continue reading...
Wildcard’s remarkable run to Wimbledon semi-finals has stunned the world and he will need to excel in specific areas to topple the French Open champion With the exception of his first‑round match against Damir Dzumhur, few people gave Arthur Fery much of a chance against any of his opponents en route to the semi-finals of Wimbledon. Certainly most expected him to lose to Grigor Dimitrov in the fou...
Wildcard’s remarkable run to Wimbledon semi-finals has stunned the world and he will need to excel in specific areas to topple the French Open champion With the exception of his first‑round match against Damir Dzumhur, few people gave Arthur Fery much of a chance against any of his opponents en route to the semi-finals of Wimbledon. Certainly most expected him to lose to Grigor Dimitrov in the fourth round and most felt Flavio Cobolli would see him off in the quarters . But the 23-year-old has shown enormous resolve and no little skill to make it to the semi-finals and though Alexander Zverev is a massive step up, anything’s possible. Here are the areas he will need to excel in to reach the Wimbledon final. Continue reading...
Unesco report shows children lost out to servicing debt in 113 countries, with 18 spending five times more on loans Most developing countries spent less on education than they did repaying debt last year, according to the UN, at the same time as global aid to education is predicted to decline by up to 30%. More was spent on servicing foreign debt than on education in 113 developing countries in 20...
Unesco report shows children lost out to servicing debt in 113 countries, with 18 spending five times more on loans Most developing countries spent less on education than they did repaying debt last year, according to the UN, at the same time as global aid to education is predicted to decline by up to 30%. More was spent on servicing foreign debt than on education in 113 developing countries in 2025, according to research by the UN’s culture and education agency, Unesco. In sub-Saharan Africa, countries spent 3.6 times more on debt than education . Continue reading...
Britain’s PM-in-waiting is right that the country has been failed by 40 years of neoliberalism. There will be obstacles, but he must embrace radicalism Of all the many prime ministers who have walked through the doors of 10 Downing Street in the past decade, the one Andy Burnham resembles most is Liz Truss. Both had a view of what was going wrong with the economy. Both wanted to break with the pol...
Britain’s PM-in-waiting is right that the country has been failed by 40 years of neoliberalism. There will be obstacles, but he must embrace radicalism Of all the many prime ministers who have walked through the doors of 10 Downing Street in the past decade, the one Andy Burnham resembles most is Liz Truss. Both had a view of what was going wrong with the economy. Both wanted to break with the politics of managed decline. Both had ambitious ideas for what needed to be done. Truss, of course, came to grief within weeks of becoming prime minister, after her tax-cutting mini-budget was brutally rejected by the financial markets . The big question for Burnham is whether he can deliver on his agenda without suffering the same fate. He can, but it won’t be easy. Larry Elliott is a Guardian columnist Continue reading...
After beating Leonard Cohen to Canada’s biggest music prize and splicing dembow with classical, the cross-cultural artist is now confronting Colombia’s new president When I speak to the Colombian Canadian musician Lido Pimienta , it’s in the run-up to Colombia’s presidential election, and she is worried. One of the two remaining candidates, Abelardo de la Espriella , “is so rightwing he wants to o...
After beating Leonard Cohen to Canada’s biggest music prize and splicing dembow with classical, the cross-cultural artist is now confronting Colombia’s new president When I speak to the Colombian Canadian musician Lido Pimienta , it’s in the run-up to Colombia’s presidential election, and she is worried. One of the two remaining candidates, Abelardo de la Espriella , “is so rightwing he wants to open up our beautiful country to fracking and the influence of the US,” she says – and at one point in his campaign, De la Espriella said he wanted to “disembowel” the left . He later waved that away as a mere figure of speech, but Pimienta fears that leftwing artists like her “would be target number one” for a De la Espriella presidency. He ended up winning in a narrow victory that brought praise from Donald Trump and a promise of “a new era, a change of order”. Despite the potential risks, the singer-songwriter has never shied away from speaking her mind. Since the release of her breakthrough second album, 2016’s La Papessa – which beat Leonard Cohen’s You Want It Darker, the last album released during his lifetime, to win Canada’s prestigious Polaris prize – 39-year-old Pimienta has made ebullient, genre-defying records that hiss with indignation at racism, colonialism, misogyny and music industry expectations. Continue reading...
Now based in London and gaining respite from relentless attention at home, Indian legend still has the form and aura that make him the main attraction In a sporting summer that is challenging even the most voracious appetites, the one-day international series between England and India that gets under way next Tuesday could be viewed as the wafer-thin mint that tips people over the edge. But for al...
Now based in London and gaining respite from relentless attention at home, Indian legend still has the form and aura that make him the main attraction In a sporting summer that is challenging even the most voracious appetites, the one-day international series between England and India that gets under way next Tuesday could be viewed as the wafer-thin mint that tips people over the edge. But for all that 50-over cricket is on the retreat, and its World Cup is still 15 months away, it is worth loosening the belt a further notch or two for this one. Virat Kohli will be back smouldering in blue for the tourists, in what will probably be the last chance to watch one of the all-time greats bat in this country. Continue reading...
England have been happy with their Kansas City base but it has led to them travelling more than the other quarter-finalists – here’s just how much more Much was made of the challenge England faced by playing Mexico at altitude in the Azteca Stadium. The greater concern might be the enormous cumulative distance the team has travelled at the World Cup. It is far greater than any of their rivals. The...
England have been happy with their Kansas City base but it has led to them travelling more than the other quarter-finalists – here’s just how much more Much was made of the challenge England faced by playing Mexico at altitude in the Azteca Stadium. The greater concern might be the enormous cumulative distance the team has travelled at the World Cup. It is far greater than any of their rivals. The Football Association chose to base England in Kansas City , even though the team were not scheduled to play any of their matches there. They reasoned that a central location would limit the length of flights the players had to take for any of their fixtures. But it has also ensured they have made round trips of at least 670 miles for every game, if we keep things simple by measuring straight lines between the cities of their base camp and match venues. Continue reading...
The Frenchman is ranked world No 12, but that is a disappointment after he became the youngest ever 2800-rated player at 18 years and five months Alireza Firouzja is shaping up to be one of the nearly men of grandmaster chess. The Iran-born Frenchman, 23, has just won the St Louis-organised Croatia Super Rapid and Blitz in Zagreb. He was far ahead at the start of the last day, but had a poor run o...
The Frenchman is ranked world No 12, but that is a disappointment after he became the youngest ever 2800-rated player at 18 years and five months Alireza Firouzja is shaping up to be one of the nearly men of grandmaster chess. The Iran-born Frenchman, 23, has just won the St Louis-organised Croatia Super Rapid and Blitz in Zagreb. He was far ahead at the start of the last day, but had a poor run of 2/7 during the final rounds before a successful Armageddon tie-break. Firouzja’s career has been limited by his below-par performances in the Candidates. In 2022, he spoiled his chances by playing blitz into the small hours; in 2024, he did worse still, finishing seventh out of eight. He made a major effort to qualify again in 2025, hiring the late Daniel Naroditsky as his coach for the Grand Swiss in Samarkand, but finished third when only two qualified. At the victory ceremony, the bronze medal podium was conspicuously uninhabited. Continue reading...
Banks and finance firms should combine their buying power to avoid losing out in negotiations with US tech giants, according to raft of Dutch proposals aimed at tackling Europe’s over-dependence on foreign providers of critical services such as AI and cloud computing. In a report presented to the Dutch government Friday, watchdogs including the nation’s central bank and data protection agency warn...
Banks and finance firms should combine their buying power to avoid losing out in negotiations with US tech giants, according to raft of Dutch proposals aimed at tackling Europe’s over-dependence on foreign providers of critical services such as AI and cloud computing. In a report presented to the Dutch government Friday, watchdogs including the nation’s central bank and data protection agency warn that digital dependencies on overseas companies “continue to grow” in entities they supervise, despite Europe ’s policy push toward strategic autonomy. They say fears over antitrust law need not be a barrier to collective buying, provided its done in line with current exemptions. The Dutch grouping propose a series of measures to reverse the trend, including prioritizing the allocation of land for data centers that contribute to Europe’s “competitiveness, autonomy and resilience” over other projects, and guarding against the takeover of strategically important European tech companies. One idea pushed by the regulators is institutions, or public authorities, “pooling demand and setting joint requirements” when procuring technology services that would make it easier to move provider later. “As supervisory authorities, we often see that firms are reluctant to cooperate but the Competition Act permits cooperation in many cases,” the report says. “We expressly invite organizations to engage in early consultation and dialogue, for example if they are uncertain about interpretation of the rules,” the report adds. The efforts come as Europe doubles down on efforts to develop its own tech infrastructure, including through a newly-launched digital sovereignty push, amid fears that over-reliance on foreign tech giants have left the bloc vulnerable to cyber attacks, outages and predatory pricing. AI has been at the forefront of the most recent concerns, after US firms were given preferential access to models from San Francisco-based Anthropic so they could fight cyber attacks, and EU ...
Andrii Yalanskyi/iStock via Getty Images By Jason Hill Fund Performance and Positioning We manage CMNIX to provide stable performance regardless of interest rates. The fund has outperformed the bond market over the quarter and year to date, as it has over longer periods. CMNIX’s Recent Performance Extends a Longer Pattern of Consistent Outperformance Data as of 6/30/2026. Source: Morningstar. Perf...
Andrii Yalanskyi/iStock via Getty Images By Jason Hill Fund Performance and Positioning We manage CMNIX to provide stable performance regardless of interest rates. The fund has outperformed the bond market over the quarter and year to date, as it has over longer periods. CMNIX’s Recent Performance Extends a Longer Pattern of Consistent Outperformance Data as of 6/30/2026. Source: Morningstar. Performance data quoted represents past performance, which is no guarantee of future results. Current performance may be lower or higher than the performance quoted. Please refer to Important Risk Information. The principal value and return of an investment will fluctuate so that your shares, when redeemed, may be worth more or less than their original cost. All performance shown assumes reinvestment of dividends and capital gains distributions. The fund’s gross expense ratio as of the prospectus dated 2/27/2026 is 1.01% for Class I shares. Hedged Equity Strategy The hedged equity strategy was the most significant contributor to returns for both the second quarter and year-to-date through June 30, 2026. Although our decision to run a heavier-than-average, more defensive hedge meant that we gave up some equity market upside participation, the increased income we earned from our hedge offset it. Higher interest rates make the calls we write more expensive and the puts we buy cheaper, and when combined with current moderate volatility levels, we believe that a more defensive, income-focused hedge remains ideal for our investors. We were also active at the margin during the quarter. The core of the hedge stayed in place, but we traded around a small piece of our end-of-June 7500 short calls as volatility moved, covering and re-selling that slice repeatedly to monetize the intra-quarter swings. We ultimately rolled a large portion of the hedge out to August. The structure of the book pays us to be hedged and patient—a posture we believe is most favorable as equities press higher and...
Your exchange-traded fund is flat. Remember that ETF you tucked away that invests in developed markets outside the U.S.—the one that looked cheap but has lagged behind the S&P 500 forever because it’s loaded with crusty old companies in Europe and Japan? By the way, both of these overseas funds, developed and emerging, beat the S&P 500 by a lot in 2025, too, but that was partly because the value o...
Your exchange-traded fund is flat. Remember that ETF you tucked away that invests in developed markets outside the U.S.—the one that looked cheap but has lagged behind the S&P 500 forever because it’s loaded with crusty old companies in Europe and Japan? By the way, both of these overseas funds, developed and emerging, beat the S&P 500 by a lot in 2025, too, but that was partly because the value of the dollar tanked last year as the Federal Reserve was cutting interest rates.