Williams is one of the most successful athletes to ever take part in tennis, but she’s also been steadily building her collection of properties for many years.
Williams is one of the most successful athletes to ever take part in tennis, but she’s also been steadily building her collection of properties for many years.
Nurix Therapeutics ( NRIX ) shares surged on Monday after the company entered a global collaboration and licensing agreement with Roche ( RHHBY ) to develop and commercialize bexobrutideg, a potential best-in-class oral BTK degrader, in a deal worth up to $3B, including a $700M upfront payment. Development costs will be shared 40% by Nurix and 60% by Roche. The parties will equally split the profi...
Nurix Therapeutics ( NRIX ) shares surged on Monday after the company entered a global collaboration and licensing agreement with Roche ( RHHBY ) to develop and commercialize bexobrutideg, a potential best-in-class oral BTK degrader, in a deal worth up to $3B, including a $700M upfront payment. Development costs will be shared 40% by Nurix and 60% by Roche. The parties will equally split the profits and losses from U.S . commercialization. Nurix and Roche will co-commercialize bexobrutideg in the United States across all indications, the companies said . Outside of the United States , Roche will be responsible for commercialization, with Nurix eligible to receive royalties ranging from the low- to high-teens. Nurix Therapeutics ( NRIX ) shares surged 43% in early trading. The collaboration encompasses a comprehensive clinical development plan spanning malignant hematology, immunology, and neurology intended to explore the full clinical potential of BTK degradation across diverse patient populations. In addition to executing the previously disclosed pivotal Phase 2 and Phase 3 trials in CLL, the collaboration plans to pursue multiple label-enabling studies across a range of malignant hematology indications as monotherapy and in combination regimens and to expand development into immune-mediated diseases, including Phase 2 trials in MS and CSU. More on Roche Holding, Nurix Therapeutics Roche Holding AG (RHHBY) Presents at American Society of Clinical Oncology (ASCO) Annual Meeting 2026 - Slideshow Nurix Therapeutics, Inc. (NRIX) Presents at RBC Capital Markets Global Healthcare Conference 2026 Transcript Roche Holding AG (RHHBY) Analyst/Investor Day Transcript Zealand phase 2 data on petrelintide shows durable weight loss IDEAYA to work with Roche on combo pancreatic cancer treatment
A 2x daily leveraged ETF that owns nothing but swaps on a single AI server stock did what 2x daily leveraged ETFs on single AI server stocks do when the AI server trade breaks. Defiance Daily Target 2X Long SMCI ETF (NASDAQ:SMCX) fell 22% on June 5, 2026, closing at $23.22 after opening near $29.95. ... SMCX Sank 67% in a Year While the Underlying Stock Rose 2%
A 2x daily leveraged ETF that owns nothing but swaps on a single AI server stock did what 2x daily leveraged ETFs on single AI server stocks do when the AI server trade breaks. Defiance Daily Target 2X Long SMCI ETF (NASDAQ:SMCX) fell 22% on June 5, 2026, closing at $23.22 after opening near $29.95. ... SMCX Sank 67% in a Year While the Underlying Stock Rose 2%
President Trump is pursuing a Bernie-like interest in having the U.S. government take stakes in AI giants — not out of populism, but with a dealmaker's eye for profit.
President Trump is pursuing a Bernie-like interest in having the U.S. government take stakes in AI giants — not out of populism, but with a dealmaker's eye for profit.
From ludicrously fun 80s love affairs to outrageously scandalous drama, this has already been a year of great television. Here are our favourite shows of the year *** Continue reading...
From ludicrously fun 80s love affairs to outrageously scandalous drama, this has already been a year of great television. Here are our favourite shows of the year *** Continue reading...
Like many couples, my husband and I bickered over who would do what and who did more. We came up with a radical solution It was when my second child was born in 2021 that I realised I needed a new system for parenting. We were coming out of lockdown, and I was tired and overwhelmed. During the pandemic, my husband and I had built our own mini unit in the UK, as our families lived in the US. I had ...
Like many couples, my husband and I bickered over who would do what and who did more. We came up with a radical solution It was when my second child was born in 2021 that I realised I needed a new system for parenting. We were coming out of lockdown, and I was tired and overwhelmed. During the pandemic, my husband and I had built our own mini unit in the UK, as our families lived in the US. I had decided to start my own literary agency as soon as my daughter was old enough to start nursery at six months. It wasn’t ideal timing, but I wanted to start as soon as possible. I approached finding a parenting system the way I think many women of my generation do, with the same intensity that we would have approached a school dissertation. I decided to crowdsource my research: I watched videos of home-schooling mums in the US demonstrating their morning routines, I read every parenting book I could, I listened to podcasters interviewing mothers who seemingly “had it all”, and listened to others who argued that “having it all” was impossible. Continue reading...
If you’re in a rut, kids can show you the way out. That’s the latest message from the author of the bestselling Steal Like an Artist. I asked him to help me rediscover my playful, creative side … As a child, I couldn’t wait to be an adult. I’d spend hours daydreaming about the future, my exciting life and what I’d do with all that autonomy, such as own exotic pets, paint my walls bright pink and s...
If you’re in a rut, kids can show you the way out. That’s the latest message from the author of the bestselling Steal Like an Artist. I asked him to help me rediscover my playful, creative side … As a child, I couldn’t wait to be an adult. I’d spend hours daydreaming about the future, my exciting life and what I’d do with all that autonomy, such as own exotic pets, paint my walls bright pink and stay up all night. Now that I’m in my mid-30s, it’s fair to say that adulthood has somewhat lost its lustre. Nothing is wrong , exactly – I’ve even achieved some of my dreams, with a bright pink bathroom and two weird cats – but there’s still a sense of going through the motions, and my days being dully predictable: gym, work, cook, clean, collapse on to the sofa. Continue reading...
Marine biologist Issah Seidu has found a way for Ghana’s fishing communities to earn a living – and help protect the ancient and critically endangered fish species Guitarfish are an odd-looking and ancient species, with the tail of a shark and the flattened body of a ray, but their coveted fins have driven populations to the brink of extinction. In west Africa, where their meat is also a local del...
Marine biologist Issah Seidu has found a way for Ghana’s fishing communities to earn a living – and help protect the ancient and critically endangered fish species Guitarfish are an odd-looking and ancient species, with the tail of a shark and the flattened body of a ray, but their coveted fins have driven populations to the brink of extinction. In west Africa, where their meat is also a local delicacy, many guitarfish species are among the most critically endangered fish in the ocean. Conservationists at the International Union for the Conservation of Nature (IUCN) describe the slow-maturing ray, which produce young annually, as an “indicator species”, which reflect the overall health of an ecosystem and pose challenges in the way coastal fishing of them is managed. The IUCN red list categorises more than half of guitarfish species as critically endangered . Continue reading...
As a former NBA player, I know that criticism is part of the game. But in an age when players are under attack constantly, the Knick star is an example to us all The entire basketball world is singing the praises of Jalen Brunson and rightfully so. He has led the Knicks to the NBA finals for the first time since 1999 and has united the entire city of New York in a unique way. On every New York str...
As a former NBA player, I know that criticism is part of the game. But in an age when players are under attack constantly, the Knick star is an example to us all The entire basketball world is singing the praises of Jalen Brunson and rightfully so. He has led the Knicks to the NBA finals for the first time since 1999 and has united the entire city of New York in a unique way. On every New York street you can see people of every race, color, creed, nationality, religion, economic status and political affiliation unified in excitement as the team seek their first NBA title since 1973. While older Knicks fans break out their Patrick Ewing, Charles Oakley and John Starks jerseys, younger fans have the names of Brunson, Josh Hart and Karl-Anthony Towns on their backs. Chants of “MVP!” fill the air in every New York borough every time Jalen Brunson steps up to the free-throw line. Knicks fans have staged watch parties on the sidewalks, in the parks, and on the corners. All of New York is, in the words of JadaKiss, “outside”. Etan Thomas played in the NBA from 2000 through 2011. He is a published author, podcaster, poet, activist and motivational speaker. Continue reading...
Even the finest miss out on a place at the finals and for those who do get there, decisions can make or break a dream Ismail Elfath was taking his children to the park near his home in Texas when a message arrived. “Congratulations,” it read. Elfath hugged his wife. Fifa had selected him for his second World Cup. Relief and pride swept over him. “Going to a World Cup is the dream of every referee,...
Even the finest miss out on a place at the finals and for those who do get there, decisions can make or break a dream Ismail Elfath was taking his children to the park near his home in Texas when a message arrived. “Congratulations,” it read. Elfath hugged his wife. Fifa had selected him for his second World Cup. Relief and pride swept over him. “Going to a World Cup is the dream of every referee, but going to a second one means you have stayed consistent for eight years plus,” he said. For referees, the World Cup is the pinnacle. The tournament comes around only every four years, and only a tiny number make the cut. “First you have to be the best in your own country, and even then you might not be selected,” the former Swiss referee Urs Meier said. Continue reading...
The latest in our series of writers highlighting their most rewatched comfort films is a dread-filled journey into the woods I’m not sure I could blame anyone for choosing, as their feelgood film, a film in which the characters feel good. Cinema is supposed to manipulate us emotionally - that’s the whole point. Nemo feels good when he’s found, and we feel good for him. By this logic, horror films ...
The latest in our series of writers highlighting their most rewatched comfort films is a dread-filled journey into the woods I’m not sure I could blame anyone for choosing, as their feelgood film, a film in which the characters feel good. Cinema is supposed to manipulate us emotionally - that’s the whole point. Nemo feels good when he’s found, and we feel good for him. By this logic, horror films should make us feel bad. So, when it was released in 1999, why did The Blair Witch Project – a film in which three film students are hunted, terrorised and presumably killed by an unseen entity – make nearly $250m at the box office? That’s the same as Love Actually. Of all the millions of people who paid to sit and watch Eduardo Sánchez and Daniel Myrick’s claustrophobic found-footage nightmare, I’m sure that not a single one of them entered the cinema hoping for their day to be ruined. I was technically too young to see The Blair Witch Project when it came out, but like so many other children of laissez-faire 90s parents, I found a way. And that way was a friend’s sleepover. Fingers slick with Pizza Hut grease, we slid the 15 certificate VHS cassette into the player and gleefully waited to have the shit scared out of us. And it did. But not in the way we were used to. Up until this point, I’d seen the likes of Hellraiser, Candyman and Nightmare on Elm Street – horror meant guts strewn across the screen like party streamers. But what Blair Witch lacked in viscera is made up for in pure, uncut dread. The fact that you never even see the titular witch somehow made it even more terrifying. Believe me, in the imagination of a child who’d been fed horror films like multipack breakfast cereals, that witch was scarier than Pinhead and Freddy Krueger’s bastard baby. And I … loved her? Continue reading...