MicroStockHub/iStock via Getty Images Investment Thesis This is my first time providing coverage of Monte Rosa Therapeutics, Inc. ( GLUE ), a Boston based biotech specializing in the development of a class of drugs known as molecular glue degraders ("MGDs"). As the company puts it in its Q1 2026 quarterly report / 10-Q filing : MGDs are small molecule drugs that employ the body’s natural protein d...
MicroStockHub/iStock via Getty Images Investment Thesis This is my first time providing coverage of Monte Rosa Therapeutics, Inc. ( GLUE ), a Boston based biotech specializing in the development of a class of drugs known as molecular glue degraders ("MGDs"). As the company puts it in its Q1 2026 quarterly report / 10-Q filing : MGDs are small molecule drugs that employ the body’s natural protein destruction mechanisms to selectively degrade therapeutically-relevant proteins. MGDs work by inducing the engagement of defined surfaces identified on target proteins by an E3 ligase, such as cereblon. We have developed a proprietary and industry-leading protein degradation discovery engine, called QuEENTM to enable our unique, and target-centric, MGD discovery and development and our rational design of MGD products. Protein degrader technology is being been developed by the likes of Kymera Therapeutics ( KYMR ), Arvinas ( ARVN ), and C4 Therapeutics ( CCCC ) and others, alongside several large Pharma companies, although only a handful of drugs with this mechanism of action ("MoA") have been approved to date. It is now recognized that lenalidomide and pomalidomide, marketed and sold as Revlimid and Pomalyst by Bristol-Myers Squibb Company ( BMY ) and indicated for multiple myeloma, are types of protein degrader drugs, as is the selective estrogen receptor degrader elacestrant, approved last January to treat breast cancer as Orserdu, and marketed and sold by Italian drugmaker Menarini, fulvestrant, another breast cancer drug marketed and sold by AstraZeneca ( AZN ) under the brand name Faslodex, and most recently Inluriyo (imlunestrant), developed by Eli Lilly ( LLY ), and also indicated for breast cancer. Monte Rosa completed its initial public offering ("IPO") in June 2021, raising ~$222m at $19 per share. At the time of writing, its stock trades at $16.8 per share, and its market cap valuation is $1.42bn. Stock is in fact up >220% on a 1-year basis. Its pipeline is illust...
A continuing rout of certain segments of the tech sector put some hurt on Microsoft (NASDAQ: MSFT) stock on Thursday. Investors also digested a media report about a long-standing unit of the company reducing its workforce. By the end of the trading day, its equity had shed nearly 2% of its value. Much of the downbeat sentiment in the sector stemmed from Oracle 's latest earnings report , released ...
A continuing rout of certain segments of the tech sector put some hurt on Microsoft (NASDAQ: MSFT) stock on Thursday. Investors also digested a media report about a long-standing unit of the company reducing its workforce. By the end of the trading day, its equity had shed nearly 2% of its value. Much of the downbeat sentiment in the sector stemmed from Oracle 's latest earnings report , released after the market close on Wednesday. At first glance, it was encouraging, with double-digit sales growth and top- and bottom-line beats. Image source: Getty Images. Continue reading
Microsoft (NASDAQ:MSFT), a leading software and cloud platform provider, closed Thursday’s session at $390.34, down 1.77%. The stock moved lower as Xbox restructuring headlines and sector-wide AI spending worries following an Oracle (NYSE:ORCL) cloud miss pressured sentiment, and
Microsoft (NASDAQ:MSFT), a leading software and cloud platform provider, closed Thursday’s session at $390.34, down 1.77%. The stock moved lower as Xbox restructuring headlines and sector-wide AI spending worries following an Oracle (NYSE:ORCL) cloud miss pressured sentiment, and
The ferocious fire that swept through a Hong Kong housing estate last year, killing 168 people and leaving about 5,000 homeless, raised many questions that need to be answered. Investigations immediately began into what happened at Wang Fuk Court and how the tragedy occurred. An ongoing independent public inquiry has already highlighted numerous areas of concern. Policies and laws are being change...
The ferocious fire that swept through a Hong Kong housing estate last year, killing 168 people and leaving about 5,000 homeless, raised many questions that need to be answered. Investigations immediately began into what happened at Wang Fuk Court and how the tragedy occurred. An ongoing independent public inquiry has already highlighted numerous areas of concern. Policies and laws are being changed in a bid to ensure lessons are learned and that a similar disaster can never happen...
Welcome to Bloomberg’s California Edition — covering all the events shaping one of the world’s biggest economies and its global influence. This week: A tale of two Tahoes. Sign up here if you’re not already on the list. Almost everyone who grew up in NorCal has fond memories of Lake Tahoe: impossible blue waters, towering pines and endless vacation days. Which is why you may want to pay attention ...
Welcome to Bloomberg’s California Edition — covering all the events shaping one of the world’s biggest economies and its global influence. This week: A tale of two Tahoes. Sign up here if you’re not already on the list. Almost everyone who grew up in NorCal has fond memories of Lake Tahoe: impossible blue waters, towering pines and endless vacation days. Which is why you may want to pay attention to what’s happening to Incline Village. Just across the border to Nevada, what was once a cheap refuge for airline pilots, then home to ski bums and middle-class vacationers is quickly becoming a billionaires’ playground . Yes, you’d be right to point out that California’s richest have often fled to Lake Tahoe ( remember Mark Zuckerberg wake surfing there? ). However, a proposed state wealth tax, combined with new fortunes minted by SpaceX and soaring AI valuations, is accelerating the migration — particularly to the tax-friendly Nevada side of the alpine lake. The result is a town of fewer than 10,000 residents being transformed into a luxury ZIP code with room for ultrarich tech titans and few others. In Incline Village, a historic property is being turned into a luxe wellness hotel featuring members-only access through underground tunnels and priority entry to “Burning Man Decompression.” The nearby airport has an eight-year waiting list for jet hangars, while the local private school is near capacity, and homes by the lake are selling at record prices — with a $125 million recent purchase ranking among the most expensive in the nation. Here’s Eliyahu Kamisher breaking down how an exodus of California wealth is leading to a tale of two Tahoes . And a handy map on the who’s who of the billionaires with homes at the Nevada side of the lake. Up Front Ultrawealthy Californians are not the only ones pushing back against new taxes . Voters in San Francisco rejected Proposition D, also known as the Overpaid CEO Act, a ballot measure that would have increased taxes on large busi...
SlavkoSereda/iStock via Getty Images CME Group ( CME ) said post-market Thursday it plans to expand 24/7 trading to new, smaller-sized crude oil and gold contracts, pending regulatory review. CME ( CME ) said the new 10-Barrel WTI Crude Oil contract will be one-tenth the size of its existing Micro WTI futures and will launch on August 30, and 24/7 trading for the company's existing 1-Ounce Gold fu...
SlavkoSereda/iStock via Getty Images CME Group ( CME ) said post-market Thursday it plans to expand 24/7 trading to new, smaller-sized crude oil and gold contracts, pending regulatory review. CME ( CME ) said the new 10-Barrel WTI Crude Oil contract will be one-tenth the size of its existing Micro WTI futures and will launch on August 30, and 24/7 trading for the company's existing 1-Ounce Gold futures would begin on July 26. The new offerings aim to allow traders to manage their trading exposure whenever news breaks, the company said. "Traders are increasingly looking to diversify their portfolios across commodity markets in the face of geopolitical uncertainty," CME Group ( CME ) Senior Managing Director and Global Head of Commodities Markets Derek Sammann said. More on CME Group CME Group Presents at Piper Sandler Global Exchange and Fintech Conference Transcript CME Group Q1 Earnings Show Strength, But The Stock Still Looks Expensive As Chicago Thaws In Spring, CME Group Remains A Hot Dividend Idea
U.S. Attorney for the District of Columbia Jeanine Pirro announces charges in connection with an international car theft ring during a press conference at the Justice Department in Washington, D.C., U.S., April 22, 2026. Nathan Howard | Reuters A federal judge in Washington denied on Thursday a prosecutor's request to erase the record of the government's legal losses its attempt to investigate for...
U.S. Attorney for the District of Columbia Jeanine Pirro announces charges in connection with an international car theft ring during a press conference at the Justice Department in Washington, D.C., U.S., April 22, 2026. Nathan Howard | Reuters A federal judge in Washington denied on Thursday a prosecutor's request to erase the record of the government's legal losses its attempt to investigate former Federal Reserve Chair Jerome Powell . Chief Judge James E. Boasberg in the D.C. Circuit's scathing order, replete with media quotes and links to YouTube clips, denied a motion by the office of U.S. Attorney Jeanine Pirro to vacate his earlier rulings that had gone against Pirro. The latest development caps a monthslong legal saga that saw Boasberg halt aspects of an investigation by Pirro into the Fed. Boasberg in March quashed a pair of subpoenas Pirro issued because, he ruled, Pirro's effort was intended at least in part to "harass and pressure Powell" on behalf of the president, who wanted lower interest rates. Read more CNBC politics coverage Trump family got about $500M from crypto venture — but investors saw steep losses Trump repeats claims that Iran deal is only 'days' away, despite recent strikes USDA Secretary Rollins calls Texas ag chief 'unserious' amid screwworm threat Trump nominates Todd Blanche for attorney general amid controversy over DOJ fund Pirro in April agreed to close the investigation of Powell under pressure from Republican Sen. Thom Tillis of North Carolina. Tillis dropped a Senate blockade of the confirmation of Kevin Warsh , Trump's nominee to replace Powell as leader of the Fed. Warsh was confirmed in May and will chair his first meeting of the Fed's rate-setting committee next week. Powell stepped down from the Fed chair as required by law but opted to retain his separate seat on the Fed's board . He wanted to ensure that the legal threat to the Fed had truly ended, even after Pirro said she had dropped the investigation. Boasberg in a sca...