Fuse Img/iStock via Getty Images SAB Biotherapeutics, Inc. ( SABS ) is a biopharmaceutical company that develops SAB-142, a potential disease-modifying therapy for immune and autoimmune conditions. Currently, the candidate is being studied for the treatment of Type 1 Diabetes (T1D), which is when the disease is in stages 2 and 3. Its lead study is SAFEGUARD, which is in a registrational Phase 2b t...
Fuse Img/iStock via Getty Images SAB Biotherapeutics, Inc. ( SABS ) is a biopharmaceutical company that develops SAB-142, a potential disease-modifying therapy for immune and autoimmune conditions. Currently, the candidate is being studied for the treatment of Type 1 Diabetes (T1D), which is when the disease is in stages 2 and 3. Its lead study is SAFEGUARD, which is in a registrational Phase 2b trial in new onset stage 3 patients. A relevant comparator for SAB-142 is another immune-modifying therapy called Tzield, acquired by Sanofi ( SNY ). However, SAB-142 is different in principle because it's suitable for stages 2 and 3. This way, it could help preserve beta-cell function and C-peptide, whereas Tzield is approved only for stage 2 patients. In my view, the stock doesn’t yet fully reflect this potential, which is why I deem it a viable speculative “Buy” for long-term investors seeking exposure to new T1D candidates. Novel T1D Candidate SAB Biotherapeutics, Inc. is a clinical-stage biopharmaceutical company that develops antibody therapeutics for immune and autoimmune disorders. SABS was founded back in 2014 and has been publicly traded on Nasdaq since 2021. It's currently headquartered in Miami Beach, Florida, with a research and development campus in Sioux Falls, South Dakota. It’s essentially concentrated on a single asset called SAB-142, but given its long-term potential for T1D, I thought it was worthwhile covering this relatively underfollowed name. Source: Corporate Presentation. March 2026. As a quick overview, SABS leverages its platform that uses genetically engineered transchromosomic cattle (Tc-Bovine). This way, they produce high-potency human immunoglobulin G (hIgG) antibodies without relying on human donors or convalescent plasma. Their cattle are immunized with a target disease antigen as they’re engineered for this purpose. Then, SABS produces fully human antibodies in response to the targeted antigen. SABS later collects plasma from the cattle an...
UK chancellor tells US audience she is ‘not convinced that this conflict has made the world a safer place’ Middle East crisis – live updates Business live – latest updates Rachel Reeves has stepped up her criticism of Donald Trump’s war on Iran, describing it as a “mistake” that has destabilised the global economy and damaged living standards around the world. In a marked fraying of the transatlan...
UK chancellor tells US audience she is ‘not convinced that this conflict has made the world a safer place’ Middle East crisis – live updates Business live – latest updates Rachel Reeves has stepped up her criticism of Donald Trump’s war on Iran, describing it as a “mistake” that has destabilised the global economy and damaged living standards around the world. In a marked fraying of the transatlantic relationship, the UK chancellor said Trump breaking off from diplomatic talks with Iran and launching airstrikes had not made the world a safer place. Continue reading...
Xavier Lorenzo | Moment | Getty Images The federal tax deadline is April 15 for most taxpayers, but if you're not ready to file, there's still time to request an IRS tax extension , experts say. "If you have not filed yet, don't panic. You still have many options," Candace Harden, senior tax analyst with the IRS, said during a webinar on Tuesday. One option is filing a tax extension via Form 4868 ...
Xavier Lorenzo | Moment | Getty Images The federal tax deadline is April 15 for most taxpayers, but if you're not ready to file, there's still time to request an IRS tax extension , experts say. "If you have not filed yet, don't panic. You still have many options," Candace Harden, senior tax analyst with the IRS, said during a webinar on Tuesday. One option is filing a tax extension via Form 4868 , which pushes the due date to October 15. But you still must pay taxes by the original April 15 deadline to avoid penalties and interest . The failure-to-file penalty is 5% of your unpaid taxes monthly, up to 25%, while the failure-to-pay penalty is 0.5% of your balance monthly, with the same cap. You should estimate your total liability, subtract taxes paid and send the balance by the original due date, according to the IRS. Read more CNBC personal finance coverage How to file a tax extension for free by the April 15 deadline Over 643,000 student loan borrowers await repayment plans, forgiveness: court filing IRS audit red flags remain despite agency budget cuts Why BLTs just got more expensive — tariffs, war send tomato prices soaring Trump accounts sign up more than 5 million kids: Treasury Market volatility can 'weigh heavily' on Gen Z, advisor says — how to cope More buyers pick 7-year car loans 'to make the numbers fit': expert Tariff refunds unlikely to benefit consumers, CNBC CFO Council survey finds Average tax refund is 11% higher, latest IRS filing data shows Social Security 2027 cost-of-living adjustment estimate rises with gas prices Here's the inflation breakdown for March 2026 — in one chart How 'married filing separately' status could affect Trump tax breaks this season Student loan forgiveness may be pricier to access after new changes Personal assistant pleads guilty to defrauding elderly couple out of $10 million CNBC's Financial Advisor 100: Best financial advisors, top firms ranked Roughly 30% of Americans said they expected to procrastinate on their t...
The stream of imported goods through Southern California’s twin ports fell about 1% last month compared to the year before, as the Iran war adds pressure and uncertainty to the global supply chain. “The Port of Long Beach led the nation as the busiest container port for the month of March,” the port’s CEO Noel Hacegaba said Wednesday. “All terminals remain open and there are no direct impacts to o...
The stream of imported goods through Southern California’s twin ports fell about 1% last month compared to the year before, as the Iran war adds pressure and uncertainty to the global supply chain. “The Port of Long Beach led the nation as the busiest container port for the month of March,” the port’s CEO Noel Hacegaba said Wednesday. “All terminals remain open and there are no direct impacts to operations, but the war in the Middle East continues to add uncertainty for global supply chains.” The San Pedro Bay port handled nearly 375,000 import containers in March, a slight 1.5% decrease over the same month last year when importers rushed to bring goods in ahead of tariffs. Hacegaba noted while March’s cargo volumes likely don’t reflect the impact of the Iran war yet, some goods are now being rerouted through Los Angeles area seaports and via air freight. When ships get rerouted to avoid conflict zones, costs go up, he said. “Continued instability in the Strait of Hormuz will keep pressure on energy prices and by extension, consumer prices,” Hacegaba said. Dockworkers at the Long Beach port handled nearly 775,000 20-foot equivalent units, or TEUs, about 5% less than last year, Hacegaba said. Exports rose slightly to more than 100,000 TEUs. And empty containers declined 11% to 296,000. Meanwhile, the Port of Los Angeles processed 752,520 TEUs last month, a 3% decrease compared to last year, according to port data. Loaded imports were 380,733 TEUs, just 1% lower than last year. Export containers totaled 132,129, an increase of 7% over 2025, and the port handled 239,658 empty container units, 11% less than last year. The energy shock from the Iran war is manifesting itself most acutely in vessel fuel prices that have doubled since the US and Israeli bombing of Iran started Feb. 28, Port of Los Angeles Executive Director Gene Seroka told Bloomberg TV this week. That was followed by Tehran’s retaliatory strikes against infrastructure in Gulf states and the near-end of tr...
FeelPic Franklin Templeton CEO Jenny Johnson maintains that the U.S. remains the world’s premier investment destination, pointing to the country’s deep markets, innovative ecosystem, and the fact that the S&P 500 ( SP500 ) represents 60% of global market capitalization. Despite concerns about tariffs and market valuations, Johnson told CNBC that America’s unique combination of rule of law and crea...
FeelPic Franklin Templeton CEO Jenny Johnson maintains that the U.S. remains the world’s premier investment destination, pointing to the country’s deep markets, innovative ecosystem, and the fact that the S&P 500 ( SP500 ) represents 60% of global market capitalization. Despite concerns about tariffs and market valuations, Johnson told CNBC that America’s unique combination of rule of law and creative financial instruments continues to attract institutional investors worldwide. Johnson downplayed the impact of tariffs on the U.S. economy, noting that imports and exports only account for 10% to 14% of GDP. “It was never going to be a huge impact on the U.S. It was much more of an impact on other countries,” she said, while highlighting that the Magnificent Seven companies ( MAGS ) are just the beginning of American dominance, particularly as AI becomes more critical across sectors. Comparing the U.S. regulatory environment to Europe’s, Johnson noted that European regulations create a significant drag on company earnings. Despite any frustrations with American policy, she concluded plainly, “The reality is it’s still the best place to invest.” However, Johnson acknowledged challenges facing innovative companies in the public markets. The pressure of quarterly earnings reporting makes it difficult for CEOs to invest in long-term technological development, with many firms choosing to stay private longer due to the vast amount of capital available in private markets. Franklin Templeton itself has been involved in blockchain technology for seven years, illustrating the kind of patient investment that public market pressures can discourage. Johnson pointed to InvestNet, a financial adviser platform taken private by Bain Capital, as an example of this dynamic. The company needed to rebuild on new technology but couldn’t justify telling shareholders that earnings would be reinvested for two years. “You can’t do that as a public company,” Johnson explained, adding that such b...
Responding to an article by the PM, Caroline Lucas says he must be clearer about climate risks, Molly Scott Cato says we must reverse Brexit and Dr Victor Ajuwon applauds Labour’s directness. Plus, letters by Toby Harris and Dr Tracey Elliott Keir Starmer’s warning that the UK should not be at the mercy of events abroad is well made ( The Iran war is a warning: Britain must build resilience – at h...
Responding to an article by the PM, Caroline Lucas says he must be clearer about climate risks, Molly Scott Cato says we must reverse Brexit and Dr Victor Ajuwon applauds Labour’s directness. Plus, letters by Toby Harris and Dr Tracey Elliott Keir Starmer’s warning that the UK should not be at the mercy of events abroad is well made ( The Iran war is a warning: Britain must build resilience – at home and with our allies in Europe, 9 April ), but would carry more weight were he to level with the British public about the full breadth of the crises we face. It is extraordinary that nowhere in an article devoted to resilience did he find space to include the growing threat posed to the UK by the dramatic decline in the health of nature around the world. It is even more extraordinary – and, frankly, unforgivable – given that his own intelligence chiefs at the joint intelligence committee (JIC) have recently spelled it out for him in no uncertain terms. In a report that the government shamefully sought first to suppress and then to redact, so that some of the most alarming warnings were removed , the JIC warned of “cascading risks” from the degradation of some of the planet’s most important ecosystems, including conflict, increased competition for resources and economic shocks. Six ecosystems “critical for UK national security” are all “on a pathway to collapse”, some potentially within five years – in other words, they face “irreversible loss of function beyond repair”. The UK’s heavy reliance on food and fertiliser imports means our food security is particularly at risk, threatening food shortages, higher prices and civil unrest. Continue reading...
Dr Helen Holt and Dr Peter Davis respond to an article by Polly Toynbee on the latest round of strikes by resident doctors Polly Toynbee is right that it is time to stop the doctors’ strikes ( Both doctors and the government are handling this strike badly – that’s why there is no end in sight, 10 April ). She suggests that doctors are not feeling the pain of industrial action, but this is far from...
Dr Helen Holt and Dr Peter Davis respond to an article by Polly Toynbee on the latest round of strikes by resident doctors Polly Toynbee is right that it is time to stop the doctors’ strikes ( Both doctors and the government are handling this strike badly – that’s why there is no end in sight, 10 April ). She suggests that doctors are not feeling the pain of industrial action, but this is far from true. We are anxious about our patients and their cancelled appointments and procedures; we are exhausted covering work that we are not familiar with; and those being paid overtime for shifts they don’t want to do are uncomfortable about the financial impact on the NHS. Many of us reluctantly supported industrial action at the beginning, with a government that wasn’t listening – wanting to support junior colleagues whose pay had fallen far behind contemporaries. Now we see how divided and conflicted resident doctors are too, and we long for a resolution. We recognise that the strikes are harmful. Communication and diplomacy are skills we pride ourselves on, and politicians have never needed them more than now. Diplomacy is the way to resolve this crisis for our NHS as well. Dr Helen Holt Consultant physician and chair of the medical staff committee , University Hospitals Dorset Continue reading...
Prof Michael Krawczak says the required molecular genetic testing comes at a cost, but should not be ruled out as it was in a recent court case I read with great astonishment your article regarding the court of appeal’s decision on proving paternity in the case of a child whose father could be either one of a pair of monozygotic twins ( Court of appeal says it cannot rule on which identical twin f...
Prof Michael Krawczak says the required molecular genetic testing comes at a cost, but should not be ruled out as it was in a recent court case I read with great astonishment your article regarding the court of appeal’s decision on proving paternity in the case of a child whose father could be either one of a pair of monozygotic twins ( Court of appeal says it cannot rule on which identical twin fathered a child, 30 April ). I was particularly surprised by the court’s statement that it was “not possible” to say which twin fathered the child. This is definitely not true. The germ cells of monozygotic twins differ with sufficient probability and to a sufficient degree to allow their respective children to be clearly assigned to either of them using molecular genetic techniques. I and my colleagues first presented the idea for this approach back in 2012, and clearly demonstrated its practical feasibility in 2018. Of course, the required molecular genetic testing entails considerable costs (currently in the five-figure range). However, whether such costs would be so “very significant” (the court’s words) as to preclude genetic testing seems highly questionable, given the potential consequences of inaction for those involved. Prof Michael Krawczak Kiel University, Germany Continue reading...
Madge Christopher was featured in an article on Storm Goretti, then Robert called My photograph appeared in your article on the aftermath of Storm Goretti ( ‘ It has been traumatic’: the Cornwall landmark left battered by Storm Goretti, 3 April ), and now I have an extraordinary tale to tell. Within a day or so of the publication, I received an email from a man called Robert who said that, more th...
Madge Christopher was featured in an article on Storm Goretti, then Robert called My photograph appeared in your article on the aftermath of Storm Goretti ( ‘ It has been traumatic’: the Cornwall landmark left battered by Storm Goretti, 3 April ), and now I have an extraordinary tale to tell. Within a day or so of the publication, I received an email from a man called Robert who said that, more than 50 years ago, we had worked in the same local government establishment, which was an office with a small number of employees. But there was more… Continue reading...
MF3d/iStock via Getty Images By Zeno Mercer I just got back from HumanX, the enterprise AI conference held last week in San Francisco. Now in its second year, HumanX has already hit a remarkable milestone: over 6,500 attendees and hundreds of speakers, ranging from Al Gore, to Fei-Fei Li (widely known as the godmother of AI), and Daniela Rus, director of MIT’s CSAIL and strategic advisor for the R...
MF3d/iStock via Getty Images By Zeno Mercer I just got back from HumanX, the enterprise AI conference held last week in San Francisco. Now in its second year, HumanX has already hit a remarkable milestone: over 6,500 attendees and hundreds of speakers, ranging from Al Gore, to Fei-Fei Li (widely known as the godmother of AI), and Daniela Rus, director of MIT’s CSAIL and strategic advisor for the ROBO Global Index suite. Zeno Mercer (front right) at Daniela Rus’ (center) more intimate roundtable discussion that occurred right after her panel “Building AI Systems That Sense, Decide, and Act” at HumanX 2026. The Biggest Takeaway? That there are now two types of companies in the world. The first treats headcount and agentic workflows + token usage/optimization as equally important inputs into how the business runs. The second is still in discovery, without a real AI strategy. The gap between them is widening by the quarter. To leaders across the world, whether it’s executive leadership, government, academic institution, or nonprofit, it is time to lock in. Others already have. If your AI strategy is rolling out Gemini or Copilot seats and tracking license utilization, you are measuring the wrong thing. The step change is not seat count. It is whether your organization knows how to design, deploy, and manage agentic workflows, including for roles that were previously considered “non-technical”. Look at how Jack Dorsey is rebuilding Block ( XYZ ) as an AI-first company. As an internal AI agent that now handles roughly 90% of code submissions, headcount came down 40%, and guidance went up. That is what an operating model built around agents looks like, not a dashboard counting chat prompts. It is also the direction that we will eventually see the majority of companies head - industry and context depending - over the coming years. The Big 3 Takeaways Trust (and budget, and access to compute) is the bottleneck, not capability. Twenty-three panels centered on the disconnect b...
The AirPods Pro 3 are $50 off, which is one of the biggest discounts we’ve seen this year. | Photo by Amelia Holowaty Krales / The Verge If you missed out on Amazon’s recent spring sales event, Best Buy’s Ultimate Upgrade Sale presents yet another opportunity to score steep discounts on some of our favorite gadgets. The five-day sale runs through April 19th and features deals on a wide range of te...
The AirPods Pro 3 are $50 off, which is one of the biggest discounts we’ve seen this year. | Photo by Amelia Holowaty Krales / The Verge If you missed out on Amazon’s recent spring sales event, Best Buy’s Ultimate Upgrade Sale presents yet another opportunity to score steep discounts on some of our favorite gadgets. The five-day sale runs through April 19th and features deals on a wide range of tech, including 4K TVs, Apple gear, smartphones, smart home devices, and more. Whether you’ve had your eye on LG’s budget-friendlier B5 OLED or Bose’s latest QuietComfort Ultra Earbuds , several Verge favorites are either at or near their record-low price. Even products released just last month — including Google’s Pixel 10A and the new 11-inch iPad Air — are on sale, so it’s not just older devices. Best of all, competing retailers like Amazon are matching many of these prices, so you can snag the same deals no matter where you shop. LG B5 OLED TV LG’s B5 TV is a great way to get OLED picture quality for less. It features support for both Dolby Vision and Dolby Atmos, along with a 120Hz panel and four HDMI 2.1 ports for hooking up the latest gaming consoles. It also runs LG’s webOS platform, supports Amazon Alexa, and provides easy access to a wide range of popular streaming apps. Where to Buy: $1299.99 $599.99 at Best Buy (48-inch) $1499.99 $799.99 at Amazon (55-inch) $1499.99 $799.99 at Best Buy (55-inch) AirPods Pro 3 The AirPods Pro 3 have a new design that improves their fit, superior noise cancellation, better bass, and fairly accurate heart rate sensors. Read our review . Where to Buy: $249.99 $199.99 at Best Buy $249 $199 at Amazon $249 $199.99 at Walmart Google Pixel 10A Google’s new Pixel 10A introduces faster wired charging, Satellite SOS, and new AI tools like Camera Coach and Auto Best Take. Otherwise, it’s basically the Pixel 9A, with the same Tensor G4 chip and a dual-camera system. Read our hands-on impressions. Where to Buy: $499 $449 at Amazon (128GB) $499 $...
Iran’s military threatened on Wednesday to shut down Red Sea trade unless the US lifted its naval blockade on Tehran’s ports, saying the ceasefire was at risk. State media reported that the commander of Iran’s joint military command warned that Iran would completely block exports and imports across the Persian Gulf region, the Sea of Oman, and the Red Sea. “Iran will act with strength to defend it...
Iran’s military threatened on Wednesday to shut down Red Sea trade unless the US lifted its naval blockade on Tehran’s ports, saying the ceasefire was at risk. State media reported that the commander of Iran’s joint military command warned that Iran would completely block exports and imports across the Persian Gulf region, the Sea of Oman, and the Red Sea. “Iran will act with strength to defend its national sovereignty and its interests,” said Ali Abdollahi. He added that the US blockade is “a...
The S&P 500 Index ($SPX ) (SPY ) today is up +0.36%, the Dow Jones Industrial Average ($DOWI ) (DIA ) is down -0.391%, and the Nasdaq 100 Index ($IUXX ) (QQQ ) is up +0.63%. June E-mini S&P futures (ESM26 ) are up +0.37%, and June E-mini Nasdaq futures...
The S&P 500 Index ($SPX ) (SPY ) today is up +0.36%, the Dow Jones Industrial Average ($DOWI ) (DIA ) is down -0.391%, and the Nasdaq 100 Index ($IUXX ) (QQQ ) is up +0.63%. June E-mini S&P futures (ESM26 ) are up +0.37%, and June E-mini Nasdaq futures...
Edison SpA said it has replaced most Qatari gas supplies disrupted by the war in the Middle East, and sees no immediate risk to serving its customers in Italy. The Italian utility, owned by Electricite de France SA , had 10 Qatari liquefied natural gas cargoes scheduled for delivery between April and mid-June — equivalent to about 1.4 billion cubic meters — that were cancelled after QatarEnergy de...
Edison SpA said it has replaced most Qatari gas supplies disrupted by the war in the Middle East, and sees no immediate risk to serving its customers in Italy. The Italian utility, owned by Electricite de France SA , had 10 Qatari liquefied natural gas cargoes scheduled for delivery between April and mid-June — equivalent to about 1.4 billion cubic meters — that were cancelled after QatarEnergy declared force majeure. The last deliveries to Edison from Qatar date back to March. Qatar is a key gas supplier to Europe, and Italy is its largest buyer in the continent, receiving roughly five cargoes a month under long-term contracts. Edison has since secured seven replacement cargoes on the spot market, six of which are sourced from the US. The first replacement cargo arrived on April 11, a second is expected imminently, a third will arrive later in April, and the remaining deliveries are scheduled along May and June. These purchases allow the company to cover most of the shortfall and maintain supply commitments. Edison’s Executive Vice President Fabio Dubini said, however, that a force majeure declared by QatarEnergy could be extended if constraints persist, adding it’s “reasonable to expect” it may be prolonged given the ongoing closure of the Strait of Hormuz. Despite the disruption, Edison described QatarEnergy as a highly reliable long-term partner, highlighting a 25-year contract in place since 2009 and a track record of meeting obligations even during past crises. The company said global gas markets remain tight but supplied, with stronger competition from Asia pushing prices higher.
Gloo (NASDAQ: GLOO) stock has been making wild swings in Wednesday's trading, but it's currently in the red on the daily session. The company's share price was down 2.3% as of 1 p.m. ET. Gloo shares had been up as much as 15.9% early in today's trading but then saw a substantial bearish reversal. The company's share price had also been down as much as 4.7% in the session before regaining some grou...
Gloo (NASDAQ: GLOO) stock has been making wild swings in Wednesday's trading, but it's currently in the red on the daily session. The company's share price was down 2.3% as of 1 p.m. ET. Gloo shares had been up as much as 15.9% early in today's trading but then saw a substantial bearish reversal. The company's share price had also been down as much as 4.7% in the session before regaining some ground. Image source: Getty Images. Continue reading