The Principal Investigator of the Study, Professor Zou Hejian from Huashan Hospital, Fudan University, said: "Current gout treatment has dual challenges of drug safety concerns and insufficient efficacy. The Phase 2 data of IBI128 have shown significant advantages in lowering uric acid. This Phase 3 study, through head-to-head design and long-term observation, is expected to provide high-level evi...
The Principal Investigator of the Study, Professor Zou Hejian from Huashan Hospital, Fudan University, said: "Current gout treatment has dual challenges of drug safety concerns and insufficient efficacy. The Phase 2 data of IBI128 have shown significant advantages in lowering uric acid. This Phase 3 study, through head-to-head design and long-term observation, is expected to provide high-level evidence-based evidence for clinical practice. As a metabolic disease with the fastest growth rate in prevalence in China, gout also has multiple unmet medical needs, including the safety risks of existing drugs, such as cardiovascular risks, hypersensitivity reactions limiting clinical application, and the risk of acute kidney injury caused by excessive uric acid excretion load; the lack of efficacy, such as insufficient drug compliance rate and medication restrictions for patients with renal impairment. Tigulixostat is expected to provide a new treatment option to better meet the above needs. As a new-generation highly selective XOI, the 100 mg dose group in the Phase 2 study (CIBI128A201) had a sUA compliance rate (< 360 μmol/L) of 81% at 16 weeks, which was significantly better than that in the febuxostat 40 mg group. In addition, it showed good safety characteristics in previous clinical studies, with good renal and cardiovascular safety. This Phase 3 study will further verify its long-term therapeutic benefits and fill the unmet medical needs. " This study adopts a randomized, double-blind, multi-center Phase 3 design, and plans to enroll 600 Chinese patients who meet the 2015 ACR/EULAR gout diagnostic criteria, and randomize them in a 1:1 ratio to receive tigulixostat 100 mg or febuxostat 40 mg for 24 weeks. The treatment period of the trial was one year. The primary endpoint was the proportion of patients with serum uric acid (sUA) < 360 μmol/L at week 24. SAN FRANCISCO and SUZHOU, China, March 22, 2026 /PRNewswire/ -- Innovent Biologics, Inc. ("Innovent", HKEX: 01801)...
Singapore’s bonds have beaten all their developed-market peers this year as the war in Iran has bolstered haven demand, and fund managers say they are still one of the safest places to be. A Bloomberg index of sovereign debt from the island state has returned 0.8% so far in 2026, outperforming 13 other global counterparts, even as surging oil prices have buffeted most fixed-income assets. That set...
Singapore’s bonds have beaten all their developed-market peers this year as the war in Iran has bolstered haven demand, and fund managers say they are still one of the safest places to be. A Bloomberg index of sovereign debt from the island state has returned 0.8% so far in 2026, outperforming 13 other global counterparts, even as surging oil prices have buffeted most fixed-income assets. That sets them apart from many traditional havens such as US Treasuries and the yen that have declined. Singapore has earned the reputation as a haven and may have “attracted capital inflows as foreign investors seek refuge during times of heightened geopolitical risk,” said Wei Ming Cheong , a fund manager at Eastspring Investments in Singapore. The relative outperformance of Singapore’s bonds is likely to continue, barring any sustained impact on the nation’s macro fundamentals, he said. This isn’t the only time Singapore’s bonds have stood out. The securities beat all their developed-nation peers in the first half of last year during a selloff triggered by US President Donald Trump’s announcement of higher global tariffs in April. Part of the reason for the positive return has been the Singapore government’s prudent financial management, according to Principal Asset Management Co. “Singapore’s recent outperformance has been underpinned by its comparatively strong fiscal position relative to many developed‑market peers,” said Howe Chung Wan , head of fixed income for Asia at Principal Asset in Singapore. This “has helped reinforce investor confidence at a time of heightened global uncertainty,” he said. The island state’s bonds have also been given an extra tailwind by the relative strength of the local currency, which is the best performer in Asia this year after the Malaysian ringgit and Chinese yuan. Read more: Singapore Central Bank to Tighten Policy in April and July, ANZ Says While quicker inflation is bad for bonds, any uptick in the nation’s consumer-price numbers due thi...
Navitas Semiconductor got a lot of attention last year as its stock price surged some 376% for the year to more than $17 per share in late October. The chipmaker's stock price has fallen back to roughly $9 per share as of March 19, but it is still up 23% year to date and 250% over the past 12 months. Navitas' meteoric rise was fueled by several factors. One of the major catalysts was a new partner...
Navitas Semiconductor got a lot of attention last year as its stock price surged some 376% for the year to more than $17 per share in late October. The chipmaker's stock price has fallen back to roughly $9 per share as of March 19, but it is still up 23% year to date and 250% over the past 12 months. Navitas' meteoric rise was fueled by several factors. One of the major catalysts was a new partnership with Nvidia to supply it with its gallium nitride (GaN) and silicon carbide (SiC) chips for AI data centers. These Navitas chips are considered faster and more efficient than traditional silicon wafers and will be used in Nvidia's next-generation data center architecture, starting in 2027. Also, Navitas is pivoting from providing chips for consumer markets -- smart phones, PC, and electronics -- to bigger power markets, like data centers, electric vehicles, and industrial. Analysts expect to see revenue decline this year, due to the pivot, but bounce back in 2027 when the Nvidia contract kicks in. Navitas stock has a median price target of $8 per share, which would suggest a 9% decline in the stock price. While Navitas stock could certainly be a stellar long-term option, it is still not consistently profitable and faces uncertainties with its pivot. A more cautious investor may want to consider a less volatile AI stock, IBM (IBM 3.44%). IBM pivots toward AI and quantum computing IBM has made the transition from a computer hardware company to an AI powerhouse, focusing on AI consulting through its watsonX platform and cloud computing. In 2025, IBM grew revenue by 8% and adjusted earnings by 12%. It also lifted its gross profit margin by 1.7 percentage points to 59.5%. For this fiscal year, it anticipates revenue growth of 5% and free cash flow to increase by about $1 billion. In March, IBM signed an agreement with Nvidia for its watsonX AI platform to increase performance and reduce costs for the extraction of large AI datasets. Expand NYSE : IBM International Business ...
TAIPEI, March 23, 2026 /PRNewswire/ -- QBit Semiconductor LTD. ("QBit") announced that it has completed its Series B fundraising round with participation from an affiliate of Arm Holdings plc. Following this investment, QBit plans to apply for an initial public offering in Taiwan by the fourth quarter of 2026. Simon Shen, Chairman and Chief Executive Officer of QBit Semiconductor Founded in 2016, ...
TAIPEI, March 23, 2026 /PRNewswire/ -- QBit Semiconductor LTD. ("QBit") announced that it has completed its Series B fundraising round with participation from an affiliate of Arm Holdings plc. Following this investment, QBit plans to apply for an initial public offering in Taiwan by the fourth quarter of 2026. Simon Shen, Chairman and Chief Executive Officer of QBit Semiconductor Founded in 2016, QBit is a fabless semiconductor design company headquartered in Taipei, Taiwan, with additional offices in Boston, United States, and Tokyo, Japan. The founding team has extensive industry experience originating from Qualcomm and CSR, bringing deep expertise in semiconductor design and system integration. QBit is one of very few semiconductor companies that have successfully developed and integrated three core technologies: Intelligent Image Process, Precision Motion Control, and Energy-Aware Sensing Management. These technologies form the foundation of QBit's differentiated system-on-chip (SoC) platforms. QBit's primary products include SoCs for multifunction printers, which are widely adopted by major tier-one international printer brands. In addition, the company's solutions are also widely used across a broad range of imaging-related applications, including medical printers, photo printers, scanners, barcode printers, and industrial printers. Looking ahead, QBit plans to leverage its SoC expertise to expand into emerging application areas such as kiosks, robotics, and drones. Besides Arm's investment, the Taiwan government currently also holds more than 6% stake in QBit, reflecting institutional support for the company's long-term development and strategic positioning within Taiwan's semiconductor ecosystem. QBit plans to apply for its IPO on the Taiwan Stock Exchange by the fourth quarter of 2026, subject to regulatory approval and market conditions. Will Abbey, Executive VP and Chief Commercial Officer, Arm, added, "Through our collaboration with QBit, we're bringing ...
Key Points Recession fears are back, and many investors are worried about their portfolios right now. Nobody knows for certain how the market will fare in the coming months. However, the market's long-term outlook remains promising. 10 stocks we like better than S&P 500 Index › The S&P 500 (SNPINDEX: ^GSPC) has dipped by 4.95% since the beginning of the year, as of this writing, while the tech-hea...
Key Points Recession fears are back, and many investors are worried about their portfolios right now. Nobody knows for certain how the market will fare in the coming months. However, the market's long-term outlook remains promising. 10 stocks we like better than S&P 500 Index › The S&P 500 (SNPINDEX: ^GSPC) has dipped by 4.95% since the beginning of the year, as of this writing, while the tech-heavy Nasdaq Composite (NASDAQINDEX: ^IXIC) has slipped 6.86% in that time. If you're starting to feel nervous about the future of the market, you're not alone. Recession fears are ramping up, and even many seasoned investors feel unnerved during periods of volatility. Will AI create the world's first trillionaire? Our team just released a report on the one little-known company, called an "Indispensable Monopoly" providing the critical technology Nvidia and Intel both need. Continue » While the bad news is that nobody knows what will happen in the coming months, the good news is that the market's long-term future is always promising. Here's how long-term investors can prepare, regardless of what's on the horizon. What history says about the future of the market No recession or bear market is exactly the same, so if we're headed for a downturn, there's no telling how long it might last or how severe it might be. Historically, though, the good times last far longer than the bad. The average S&P 500 bear market since 1929 has lasted 286 days, according to analysis from Bespoke Investment Group, or around nine months. Meanwhile, the average bull market has lasted more than 1,000 days -- or close to three years. Of course, some of those bear markets were still brutal in the short term. Many investors remember the Great Recession and the dot-com bubble burst. At the time, those recessions seemed as if they would last an eternity. But even they were only temporary, and the market eventually went on to earn record-breaking returns. In fact, since 2000, the S&P 500 has earned total ret...
Activist investors are piling into Japanese shipping stocks as limited shipbuilding capacity and elevated freight rates boost the value of their fleets. Elliott Investment Management LP said earlier this month that it has taken a “significant” stake in Mitsui OSK Lines Ltd. , adding that “the market materially undervalues the business”. This follows a similar move by investment firm Fuel, which bu...
Activist investors are piling into Japanese shipping stocks as limited shipbuilding capacity and elevated freight rates boost the value of their fleets. Elliott Investment Management LP said earlier this month that it has taken a “significant” stake in Mitsui OSK Lines Ltd. , adding that “the market materially undervalues the business”. This follows a similar move by investment firm Fuel, which built a stake of about 5% in Tamai Steamship Co. Vessel prices, which have been trending upward globally, driven by robust demand, inflation and limited shipbuilding capacity have also been lifting unrealized gains of shipping fleets. The war in the Middle East has also lifted freight rates. Large tankers with an age of 15 years are now valued at around $78 million — up 39% this year and are at the highest level since records began in 2013. Elliott believes Mitsui OSK should sell off its property assets or seek a relisting for its real estate subsidiary, Daibiru, in order to improve its valuation, according to people familiar with the fund’s thinking. Additionally, Elliott is also focused on the potential gains to the company’s capital efficiency from selling and leasing back some of its fleet, the people added. The US activist fund believes the market value of the vessels Mitsui OSK owns are worth more than double their book value of 1.3 trillion yen, the people said. Elliott Investment, Mitsui OSK and Tamai Steamship declined to comment. Good quality, Japanese-built used vessels command high prices, and transport disruptions due to the Iran war have further boosted valuations of large tankers, said Veson Nautical Corp. analyst Rebecca Galanopoulos . Bulk carriers are also valued at a record $34 million on average, according to data compiled by the US shipping solution firm. “Dry bulk carrier prices are at historically high levels, and the company should consider realizing paper gains through measures such as leasebacks,” said Yushun Ozawa, CEO of investment firm Fuel, refer...