Vertex Pharmaceuticals ( VRTX ) announced on Wednesday that the U.S. FDA approved label expansions for Alyftrek and Trikafta, its treatments for cystic fibrosis, a hereditary disease caused by mutations in the CFTR gene. Alyftrek is Vertex's ( VRTX ) next-generation, triple-combination CFTR modulator taken once daily, while Trikafta, another CFTR modulator, requires twice-daily dosing. “With this ...
Vertex Pharmaceuticals ( VRTX ) announced on Wednesday that the U.S. FDA approved label expansions for Alyftrek and Trikafta, its treatments for cystic fibrosis, a hereditary disease caused by mutations in the CFTR gene. Alyftrek is Vertex's ( VRTX ) next-generation, triple-combination CFTR modulator taken once daily, while Trikafta, another CFTR modulator, requires twice-daily dosing. “With this label expansion, any variant that results in production of CFTR protein is now included in the ALYFTREK and TRIKAFTA labels,” said Carmen Bozic, chief medical officer of Vertex ( VRTX ). The label expansion on Alyftrek allows its use in CF patients aged six years and older with a variant in the CFTR gene that leads to the production of the CFTR protein or is found to be responsive based on clinical and/or non-clinical data. As for Trikafta, the FDA has expanded the indication to include CF patients aged two years and older. Following the label expansions, nearly 800 more people with CF in the U.S. will become eligible for a CFTR modulator for the first time, the company said in a statement. More on Vertex Pharmaceuticals Vertex Pharmaceuticals Incorporated (VRTX) Presents at Barclays 28th Annual Global Healthcare Conference Transcript Vertex Pharmaceuticals Incorporated (VRTX) Presents at Leerink Global Healthcare Conference 2026 Transcript Is A Vertex Buyout Of Crispr Therapeutics Inevitable? Here's My Take Vertex completes rolling BLA submission for povetacicept Vertex Pharmaceuticals climbs on positive interim data from IgAN phase 3 trial
In this article ORCL Follow your favorite stocks CREATE FREE ACCOUNT Oracle Corp. signage on the floor of the New York Stock Exchange (NYSE) in New York, US, on Wednesday, Dec. 31, 2025. Michael Nagle | Bloomberg | Getty Images Oracle rose in premarket trading on Wednesday as the multinational tech conglomerate looks to cut thousands of jobs to free up cash to build AI data center infrastructure. ...
In this article ORCL Follow your favorite stocks CREATE FREE ACCOUNT Oracle Corp. signage on the floor of the New York Stock Exchange (NYSE) in New York, US, on Wednesday, Dec. 31, 2025. Michael Nagle | Bloomberg | Getty Images Oracle rose in premarket trading on Wednesday as the multinational tech conglomerate looks to cut thousands of jobs to free up cash to build AI data center infrastructure. The software giant has started telling its 162,000-strong workforce that thousands of people will be affected in a new round of layoffs, two people familiar with the matter told CNBC on Tuesday. Its shares were last up 2.6% in early market trading on Wednesday. Oracle declined to comment on CNBC's report. Investors remain uneasy about the company's hefty capital expenditure on data centers that can handle AI workloads . While shares closed up nearly 6% Tuesday, Oracle's stock is down roughly 25% so far this year. Oracle cutting thousands in latest layoff round as company continues to ramp AI spending The company announced plans in early February to fundraise up to $50 billion during the 2025 calendar year through a mixture of debt and equity, to expand capacity for contracted cloud demand from customers, including Nvidia , Meta , OpenAI, Advanced Micro Devices and xAI. Major AI hyperscalers Alphabet , Microsoft , Meta and Amazon have also committed to capital expenditure of nearly $700 billion to fund their AI buildouts this year, which has alarmed investors as it will reduce the companies' free cash flow without a clear promise on near-term returns. watch now VIDEO 3:47 03:47 Oracle's AI spending surge sparks bubble concerns Squawk Box Europe Job cuts at Oracle will help free up cash flow, Barclays analysts said in a note on Thursday. The investment bank said it is its overweight rating of the stock. "Given ORCL's existing FY26 Restructuring Plan and prior reports, we do not see today's layoffs as being a surprise to the market, which seemed to have appreciated the cost sa...
This little-known business development company (BDC) is trading 26% below its net asset value (NAV) per share and is doling out a sustainable high-octane yield.
This little-known business development company (BDC) is trading 26% below its net asset value (NAV) per share and is doling out a sustainable high-octane yield.
Nathan Howard/Getty Images News P resident Donald Trump said he is considering withdrawing the U.S. from NATO, calling the 77-year-old defense alliance a “paper tiger” in an interview with The Telegraph newspaper published Wednesday. “I was never swayed by NATO. I always knew they were a paper tiger, and Putin knows that too, by the way,” Trump said. When asked if he would reconsider U.S. membersh...
Nathan Howard/Getty Images News P resident Donald Trump said he is considering withdrawing the U.S. from NATO, calling the 77-year-old defense alliance a “paper tiger” in an interview with The Telegraph newspaper published Wednesday. “I was never swayed by NATO. I always knew they were a paper tiger, and Putin knows that too, by the way,” Trump said. When asked if he would reconsider U.S. membership after the Iran conflict ends, he responded, “Oh yes, I would say [it’s] beyond reconsideration.” The threat comes amid growing tension between the U.S. and European allies over their refusal to help reopen the Strait of Hormuz or allow American forces to use military bases for operations against Iran. European leaders view the Iran conflict as a war of choice that they were not consulted on before it began in late February. Secretary of State Marco Rubio echoed the president’s frustration Monday, telling Al Jazeera that Washington would have to “re-examine” its relationship with NATO once the war ends. Rubio said Tuesda y that Washington could see the "finish line" in the Iran war and that the U.S. will have to re-examine ties with NATO after the conflict. British Prime Minister Keir Starmer reportedly responded to Trump’s criticism at a press conference Wednesday, saying he would not change his position on joining the war “whatever the pressure, whatever the noise. I am the British prime minister and I have to act in our national interests,” he said. Meanwhile, Trump is set to deliver a prime-time address on Wednesday at 9 p.m. Washington time to provide an update on the war in Iran. Dear readers: We recognize that politics often intersects with the financial news of the day, so we invite you to click here to join the separate political discussion. More on the Markets Hope Boosts Risk Appetites And Drags The Greenback Lower Sell The Rally - There Is No Easy Way Out Of Iran War Chart Of The Day: Deal Volume Jumps In Q1 (But Will It Persist?) U.S. stock dispersion signals...
Suspension Lifted On Helicopter Crews For Viral Fly-By At Kid Rock's Home Authored by Troy Myers via The Epoch Times, Two AH-64 Apache helicopter crews were suspended, then quickly unsuspended Tuesday after they hovered next to Kid Rock’s “Southern White House” home in Nashville on Saturday. The long-time country rock musician posted a video of the fly-by on X, showing him clapping and saluting th...
Suspension Lifted On Helicopter Crews For Viral Fly-By At Kid Rock's Home Authored by Troy Myers via The Epoch Times, Two AH-64 Apache helicopter crews were suspended, then quickly unsuspended Tuesday after they hovered next to Kid Rock’s “Southern White House” home in Nashville on Saturday. The long-time country rock musician posted a video of the fly-by on X, showing him clapping and saluting the helicopter crews, whose suspension was a discretionary step for an investigation , the Army said in a statement Tuesday. Department of War Secretary Pete Hegseth pulled that suspension later the same day. “Thank you [Kid Rock]. [U.S. Army] pilots suspension LIFTED. No punishment. No investigation. Carry on, patriots,” Hegseth wrote on X. Prior to the secretary’s announcement, the army released a statement about the Saturday fly-by. “The Army has confirmed that on March 28, two Apache helicopters from the 101st Combat Aviation Brigade at Fort Campbell conducted a flight in the Nashville area that has attracted public and media attention,” the Army said. Kid Rock’s video on X, which he captioned with a grateful message to the U.S. military and a jab at California Gov. Gavin Newsom, has garnered more than 10 million views as of this publication. Standing next to a replica of the Statue of Liberty, Kid Rock claps, salutes, and raises his fist as one of the helicopters hovers near his pool. The second helicopter can be seen zipping by in the background of a second video post on X. Trump commented on the Army’s suspension of the crews, telling reporters in the Oval Office, “They probably shouldn’t have been doing it … You’re not supposed to be playing games. “But I’ll take a look at it. You like Kid Rock? I like Kid Rock. Maybe they were trying to defend him—I don’t know.” Kid Rock, whose real name is Robert James Ritchie, told a local Nashville station that it’s not uncommon for helicopters from nearby Fort Campbell to pass near his 27,000-square-foot mansion. “I think they kn...
VivoSim Labs ( VIVS ) announced on Wednesday the pricing of up to a $4M best-efforts public offering, with $3M funded at an initial closing of the offering and another $1M to be funded on the 30 th day following the date of the initial closing. The initial closing of the offering is expected to occur on April 1, 2026. The initial closing of the public offering consists of the issuance and sale of ...
VivoSim Labs ( VIVS ) announced on Wednesday the pricing of up to a $4M best-efforts public offering, with $3M funded at an initial closing of the offering and another $1M to be funded on the 30 th day following the date of the initial closing. The initial closing of the offering is expected to occur on April 1, 2026. The initial closing of the public offering consists of the issuance and sale of $3 million in common stock at a subscription price of $1.140 per share and $1.139 per prefunded warrant, representing 286,557 common shares and 2.34M prefunded warrants. Additionally, the company will issue 3.95M common warrants to purchase up to 150% of the aggregate number of shares of common stock sold at the initial closing. Such common warrants will have an exercise price of $1.710 per share, will be immediately exercisable, and will expire five years from their date of issuance. The prefunded warrants will have an exercise price of $0.001 per prefunded warrant share, will be immediately exercisable, and will expire when exercised in full. The second closing will consist of the issuance and sale of an additional $1M in common stock (or pre-funded warrant in lieu of common stock) and common warrants to purchase up to 150% of the aggregate number of shares of common stock (or pre-funded warrants) sold at the second closing. The second closing is subject to the satisfaction of certain conditions, including conditions related to minimum closing price and average trading volume. VIVS -34.84% premarket to $0.9317. Source: Press Release More on Organovo Holdings VivoSim launches $4M offering with warrants and two-tranche structure Financial information for Organovo Holdings
Joe Raedle/Getty Images News NASA is preparing to send four astronauts on a roughly 10-day journey around the moon as early as Wednesday evening, a mission that represents the agency’s most significant human spaceflight effort in decades and a key milestone in its plan to return astronauts to the lunar surface ahead of China’s anticipated crewed landing. Mission managers confirmed a “go” decision ...
Joe Raedle/Getty Images News NASA is preparing to send four astronauts on a roughly 10-day journey around the moon as early as Wednesday evening, a mission that represents the agency’s most significant human spaceflight effort in decades and a key milestone in its plan to return astronauts to the lunar surface ahead of China’s anticipated crewed landing. Mission managers confirmed a “go” decision on Monday for liftoff of the 322-foot Space Launch System rocket carrying the Orion crew capsule, with a launch window opening at 6:24 p.m. EDT from Kennedy Space Center. The launch site sits near the historic pad used during the Apollo program. The Artemis II crew includes NASA astronauts Christina Koch, Victor Glover and Reid Wiseman, alongside Canadian astronaut Jeremy Hansen. The team recently completed a quarantine period and spent time with family before final launch preparations. Launch director Charlie Blackwell-Thompson said conditions appear favorable heading into the countdown, with only a modest risk of weather disruption during the two-hour launch window. If needed, backup opportunities extend through early April, with a later window opening at the end of the month. The mission had previously been delayed from earlier target dates due to a hydrogen leak that required engineers to roll the rocket back for inspection. Record-setting journey Artemis II will carry astronauts approximately 252,000 miles (405,554.69 kilometers) into space, surpassing the distance reached by the crew of Apollo 13, which holds the current record for the farthest human spaceflight. That mission was forced to abort its lunar landing after an onboard explosion. No humans have traveled beyond Earth orbit since 1972. NASA’s first Artemis mission in 2022 tested the Orion spacecraft on a similar trajectory without a crew. Testing systems for future landings Unlike its uncrewed predecessor, Artemis II will put Orion and the Space Launch System through more rigorous testing with astronauts onbo...