Oselote/iStock via Getty Images Pfizer ( PFE ), Alnylam Pharma ( ALNY ), and BridgeBio Pharma ( BBIO ), which market drugs for a rare heart condition known as ATTR-CM, are on the rise in the premarket on Thursday after AstraZeneca ( AZN ) and Ionis Pharma ( IONS ) failed in a late-stage trial for a rival therapy. AstraZeneca ( AZN ) shares fell ~8%, and Ionis ( IONS ) lost ~20% after the companies...
Oselote/iStock via Getty Images Pfizer ( PFE ), Alnylam Pharma ( ALNY ), and BridgeBio Pharma ( BBIO ), which market drugs for a rare heart condition known as ATTR-CM, are on the rise in the premarket on Thursday after AstraZeneca ( AZN ) and Ionis Pharma ( IONS ) failed in a late-stage trial for a rival therapy. AstraZeneca ( AZN ) shares fell ~8%, and Ionis ( IONS ) lost ~20% after the companies said that their CARDIO-TTRansform Phase 3 trial for the once-monthly RNA-targeted silencer Wainua didn’t meet the primary goal in patients with ATTR-CM. Also known as transthyretin-mediated amyloid cardiomyopathy, ATTR-CM is a fatal heart condition affecting 300,000 to 500,000 people worldwide. BridgeBio ( BBIO ) and Alnylam ( ALNY ) received FDA approval for their ATTR-CM products, Attruby and Amvuttra, in November and March 2025, respectively, challenging the then-market leader, Pfizer ( PFE ), whose ATTR-CM therapy, Vyndamax, generated $5.4B in global revenue in 2024. The companies are expected to retain their dominance in the market after the setback to Astra ( AZN ) and Ionis ( IONS ), which said they would analyze the full CARDIO-TTRansform results for the purpose of further understanding the data. BridgeBio ( BBIO ) and Alnylam ( ALNY ) have added ~15% and ~18% in the premarket so far, respectively, while Pfizer ( PFE ) is trading ~1% higher. Meanwhile, Intellia Therapeutics ( NTLA ), whose gene-editing therapy, nex-z, developed with Regeneron Pharmaceuticals ( REGN ), is currently in late-stage development for ATTR-CM, has added ~1%. More on Pfizer, Alnylam Pharmaceuticals, etc. BridgeBio: 3 New Drug Approvals In Sight Outweigh Attruby Issues, Still Bullish Pfizer: Why Being Bullish Makes Sense Despite The Patent Cliff Alnylam Pharmaceuticals, Inc. (ALNY) Discusses ALN-6400 RNAi Therapy Targeting Plasminogen for Rare Bleeding Disorders Transcript White House weighing contenders for FDA's top job Most and least shorted mid- to mega-cap healthcare stocks at the end o...
Sean Gallup/Getty Images News Drone warfare has come a long way over the last century. What started primarily as a weapon for spying and surveillance has turned into loitering munitions and kamikaze UAVs, shaping the modern battlefield in every arena. That includes the war in Ukraine, where Fire Point drone swarms continue to take out Russian refineries, clashes between Israel and Hezbollah, as we...
Sean Gallup/Getty Images News Drone warfare has come a long way over the last century. What started primarily as a weapon for spying and surveillance has turned into loitering munitions and kamikaze UAVs, shaping the modern battlefield in every arena. That includes the war in Ukraine, where Fire Point drone swarms continue to take out Russian refineries, clashes between Israel and Hezbollah, as well as the U.S. military operation in Iran, where the Islamic Republic's Shahed drones have wreaked havoc on shipping in the Strait of Hormuz. Backdrop: While there were early attempts at suicide drones, like the U.S. Navy's TDR-1 in World War II and repurposed F6F-5K Hellcats during the Korean War, the technology surrounding cameras and radios at the time was incredibly heavy, easily jammed, fragile and expensive. In the subsequent decades, nations focused on cruise missiles as their choice for one-way weapons, but that changed in the 1990s, when Israel sold its IAI Harpy to several international militaries. However, many countries, like the U.S., still chose to rely on complex and expensive reusable drones like General Atomics' Predator and Reaper, which dominated the skies throughout the 2000s and 2010s. Modern suicide drones, like SpektreWorks' LUCAS, are more economical, with features that are making them a staple in the U.S. arsenal. Compared to cruise missiles, kamikaze drones are unmatched in affordability and can be deployed in large numbers to overwhelm enemy defenses. They can also loiter in the air for minutes or hours, giving operators the ability to search and strike moving or hidden targets, and some units can even be recalled once fired. Drones can additionally travel low to the ground to avoid enemy radar and don't require the massive logistics needed to launch cruise missiles, like specialized trucks, ships or bombers. New realities: It's not only about a good offense. NATO is now beginning to pivot as well, announcing the launch of the "Drone Edge" initiat...
The S&P 500 (^GSPC) is full of established businesses, but only some continue to outperform the market. A few standout companies are thriving thanks to strong fundamentals and sustained competitive advantages.
The S&P 500 (^GSPC) is full of established businesses, but only some continue to outperform the market. A few standout companies are thriving thanks to strong fundamentals and sustained competitive advantages.
David McNew/Getty Images News FuelCell Energy ( FCEL ) up 11.4% pre-market Thursday after announcing a collaboration with Siemens ( SIEGY ) to explore scalable fuel cell power solutions. As part of the collaboration, Siemens ( SIEGY ) will design and supply electrical balance of plant (EBOP) systems for fuel cell installations, supporting the rapid deployment of 100-plus MW commercial projects. Th...
David McNew/Getty Images News FuelCell Energy ( FCEL ) up 11.4% pre-market Thursday after announcing a collaboration with Siemens ( SIEGY ) to explore scalable fuel cell power solutions. As part of the collaboration, Siemens ( SIEGY ) will design and supply electrical balance of plant (EBOP) systems for fuel cell installations, supporting the rapid deployment of 100-plus MW commercial projects. The work will include joint project development spanning engineering, integration, and delivery of distributed energy systems incorporating fuel cells, battery energy storage, microgrid controls, and medium-voltage electrical equipment, the companies said. "By combining FuelCell Energy’s fuel cell technology with Siemens’ electrical infrastructure, service, and integration expertise, we can deliver scalable, on-site power solutions for energy-intensive applications — helping customers deploy power faster, scale with confidence, and advance their transition to lower-emission, more resilient energy systems," Siemens ( SIEGY ) said. More on FuelCell Energy and Siemens FuelCell Energy: AI Data Center Opportunity Still Questionable, But Improved Access To Capital FuelCell Energy: What Goes Up Must Always Come Back Down Siemens: Still Looks Early In Its AI Repricing
Starbucks ( SBUX ) is expanding its use of AI across its operations as the coffee chain seeks to reduce its reliance on software from Microsoft ( MSFT ) and IBM ( IBM ), Bloomberg reported, citing an internal company presentation. The coffee store is building alternatives to Microsoft's ( MSFT ) inventory management system and IBM's ( IBM ) maintenance management software, with some internally dev...
Starbucks ( SBUX ) is expanding its use of AI across its operations as the coffee chain seeks to reduce its reliance on software from Microsoft ( MSFT ) and IBM ( IBM ), Bloomberg reported, citing an internal company presentation. The coffee store is building alternatives to Microsoft's ( MSFT ) inventory management system and IBM's ( IBM ) maintenance management software, with some internally developed applications expected to roll out by the end of next year, pending testing, the report said . CTO Anand Varadarajan told employees earlier this year that Starbucks ( SBUX ) spends about $400M annually on software and sees "clear opportunities to reduce the spend in software." The company is reviewing every technology contract and service and, in some cases, building its own software to replace applications that engineers already heavily customize. Starbucks ( SBUX ) has also been working for several years on a point-of-sale system designed to replace Oracle's ( ORCL ) Simphony platform. AI-assisted coding played a key role in developing the platform that could replace IBM's ( IBM ) tool, according to the internal presentation. Starbucks ( SBUX ) has been pushing its tech workers to use AI, even factoring AI usage into employee bonuses. The enterprise technology team is on track to reduce its budget by about $30M in the fiscal year ending in late September, including about $10M in software savings and another $13M primarily from reducing contractor spending and replacing some roles with in-house staff. The initiative comes as the coffee chain ( SBUX ) aims to cut $2B in costs during its turnaround. The move is part of Starbucks' ( SBUX ) broader technology strategy under CEO Brian Niccol, who has prioritized faster service, operational improvements, and a better in-store experience. More on Starbucks Starbucks: Comps Turnaround And Operating Income Surge (Upgrade) Starbucks: The Market Is Pricing In Success Too Soon Starbucks Corporation (SBUX) Presents at The 6th Ann...
Meta Platforms plans to start manufacturing an artificial intelligence chip from September as part of its plan to boost overall computing power to 14 gigawatts next year, showed an internal memo reviewed by Reuters. The tech firm's data center chip, code-named "Iris", is part of a four-generation project for Meta Training and Inference Accelerators (MTIA) that it will design in-house. Meta tailo...
Meta Platforms plans to start manufacturing an artificial intelligence chip from September as part of its plan to boost overall computing power to 14 gigawatts next year, showed an internal memo reviewed by Reuters. The tech firm's data center chip, code-named "Iris", is part of a four-generation project for Meta Training and Inference Accelerators (MTIA) that it will design in-house. Meta tailored the chip for its own needs and is working with Broadcom to help design it and Taiwan Semiconductor Manufacturing Co to manufacture it.
Democrat Graham Platner ended his bid last night for U.S. Senate. And, prominent civil rights attorney Ben Crump has been enlisted to help get answers in the July Fourth weekend death of Nolan Wells. (Image credit: Laura Brett)
Democrat Graham Platner ended his bid last night for U.S. Senate. And, prominent civil rights attorney Ben Crump has been enlisted to help get answers in the July Fourth weekend death of Nolan Wells. (Image credit: Laura Brett)
Versatile Essex-born hitmaker known for Rhinestone Cowboy, It Only Takes a Minute and many more had been living with Alzheimer’s disease Brian Potter, one of the most versatile and successful British producers and songwriters of his generation, has died aged 87. He had been living with Alzheimer’s disease in recent years, his daughter told Billboard. Working with American songwriting partner Denni...
Versatile Essex-born hitmaker known for Rhinestone Cowboy, It Only Takes a Minute and many more had been living with Alzheimer’s disease Brian Potter, one of the most versatile and successful British producers and songwriters of his generation, has died aged 87. He had been living with Alzheimer’s disease in recent years, his daughter told Billboard. Working with American songwriting partner Dennis Lambert, the Essex-born Potter was behind an astounding array of 1970s hits spanning pop, soul, soft rock, country and beyond. The best-known include Glen Campbell’s Rhinestone Cowboy, a US No 1 in 1975; It Only Takes a Minute, a barnstorming disco hit for Tavares and later Take That; Player’s super-smooth Baby Come Back, another US No 1; and Ain’t No Woman (Like the One I’ve Got), one of the biggest hits for soul-poppers the Four Tops. Continue reading...
Biden Defender JB Pritzker Now Claims Trump Has 'Dementia' Authored by Luis Cornelio via Headline USA , Illinois Gov. JB Pritzker , one of President Joe Biden’s most vocal defenders when the former president faced questions about his mental acuity, is now claiming President Donald Trump has dementia. Pritzker made the remarks during a June 29 interview with CNN host Caitlin Collins while discussin...
Biden Defender JB Pritzker Now Claims Trump Has 'Dementia' Authored by Luis Cornelio via Headline USA , Illinois Gov. JB Pritzker , one of President Joe Biden’s most vocal defenders when the former president faced questions about his mental acuity, is now claiming President Donald Trump has dementia. Pritzker made the remarks during a June 29 interview with CNN host Caitlin Collins while discussing Trump’s criticism of democratic socialism. Trump had argued that socialism represents a similar threat to the country than historical crises. “The man is continually suffering from dementia. I don’t think he really understands what he’s saying,” Pritzker stated, providing no evidence for his claim. Gov. JB Pritzker says he thinks President Trump has dementia. "I really think that there's something genuinely wrong with him," he says, while adding, "I'm not a doctor." pic.twitter.com/Y2vrFvScz8 — Kaitlan Collins (@kaitlancollins) July 1, 2026 Pritzker’s comments mark a stark contrast from how he defended Biden during the 2024 presidential campaign, when questions about the former president’s mental fitness intensified. Pritzker served as one of Biden’s fiercest campaign surrogates and even sat on his national advisory board. For instance, when Special Counsel Robert Hur raised concerns about Biden’s memory, Pritzker quickly went on the defensive , going as far as accusing Hur of being politically motivated. “I’ve been with the President of the United States many times. He is on the ball. The man knows more than most of us have forgotten,” Pritzker claimed in February 2024. "Joe Biden is on the ball. The man knows more than most of us have forgotten." - JB Pritzker in 2024. https://t.co/wBEn8sWFOP pic.twitter.com/pUCJRd0T2t — Greg Price (@greg_price11) April 8, 2026 In 2023, ahead of the presidential election, Pritzker downplayed questions about Biden’s fitness for office, praising him as “a gem of a human” while describing Trump as “cruel, cowardly and small.” Pritzker doub...