peterschreiber.media Invivyd ( IVVD ) shares rose on Thursday after the Waltham, Massachusetts-based biotech announced progress in a late-stage trial for VYD2311, its experimental therapy to prevent COVID-19 symptoms. Based on an interim analysis of its Phase 3 pivotal study, DECLARATION, the company stated that the trial has already recorded sufficient clinical events, which could support the sta...
peterschreiber.media Invivyd ( IVVD ) shares rose on Thursday after the Waltham, Massachusetts-based biotech announced progress in a late-stage trial for VYD2311, its experimental therapy to prevent COVID-19 symptoms. Based on an interim analysis of its Phase 3 pivotal study, DECLARATION, the company stated that the trial has already recorded sufficient clinical events, which could support the statistical power required to prove the high end of VYD231's targeted efficacy levels. The sample-size re-estimation analysis, which was added to improve the study’s statistical power and conducted on April 6 (Day 45), has triggered upsizing of the trial by nearly 500 additional enrollments, Invivyd ( IVVD ) noted. As a result, subject to recruitment rates, the company said that it shifted the timeline to share DECLARATION’s topline data by roughly two months, to Q3 2026 from mid-2026. “Our conservative upsizing algorithm means that we can move to higher confidence in statistical power with very modest additional time,” Invivyd ( IVVD ) chairman Marc Elia added. More on Invivyd Invivyd: A Logical Bull Thesis With A Major Catalyst Approaching Invivyd, Inc. 2025 Q4 - Results - Earnings Call Presentation Invivyd, Inc. (IVVD) Q4 2025 Earnings Call Transcript Invivyd outlines mid-2026 pivotal data timeline for VYD2311 as DECLARATION study reaches target enrollment Invivyd rises as FDA agrees with late-stage trial design for COVID-19 therapy
AlexSecret/iStock via Getty Images Key themes for 2Q 2026 Crosscurrents and risks confront the global economy The latest Middle East conflict and energy shock are posing downside risks to global activity and upside risks to global inflation. As a net energy exporter, the U.S. is the least vulnerable. By contrast, Europe and Asia are very exposed. The U.S. economy is likely to cool slightly as cons...
AlexSecret/iStock via Getty Images Key themes for 2Q 2026 Crosscurrents and risks confront the global economy The latest Middle East conflict and energy shock are posing downside risks to global activity and upside risks to global inflation. As a net energy exporter, the U.S. is the least vulnerable. By contrast, Europe and Asia are very exposed. The U.S. economy is likely to cool slightly as consumers bear the brunt of higher oil prices Although the U.S. economy still displays solid macro foundations, tightening financial conditions are likely to create challenges across the economy. Increased gasoline prices almost fully offset the benefits of the OBBBA tax refund. The Federal Reserve is still set to cut rates, while other central banks lean toward hikes The labor market has softened, but inflationary concerns imply the Fed will delay rate cuts until late 2026. The ECB and the Bank of England target price stability, so they have less flexibility to tolerate upside inflation risks and will not cut rates this year. Equity market resilience is being tested The path forward for U.S. equities is challenged, but the economy’s underlying resilience and the strength of corporate margins suggest that any drawdown should remain contained. While the recent outperformance of non-U.S. equities has stalled, once the conflict ends, international markets will offer compelling opportunities at attractive valuations. Fixed income: Tight spreads, but benefiting from robust macro tailwinds Pricing out of central bank cuts is driving front-end sovereign yields higher, while longer-end yields should trend lower as economic activity slows. Solid balance sheets and stable leverage should limit credit spread widening. Focus on resilience and diversification Another shock to test global growth resilience Last year, economic strength across key regions—the U.S., Europe, and China—defied expectations that tariffs, lingering inflation, and geopolitics would suppress growth. As 2026 unfolds, t...
Looking at options trading activity among components of the S&P 500 index, there is noteworthy activity today in Walmart Inc (Symbol: WMT), where a total volume of 88,303 contracts has been traded thus far today, a contract volume which is representative of approximately 8.8
Looking at options trading activity among components of the S&P 500 index, there is noteworthy activity today in Walmart Inc (Symbol: WMT), where a total volume of 88,303 contracts has been traded thus far today, a contract volume which is representative of approximately 8.8
The ClearBridge Dividend Strategy ( SOPAX ) outperformed the S&P 500 in Q1 2026, as the benchmark fell 4.3% while the portfolio was broadly flat on a gross-of-fees basis. The fund established new positions in Blackstone (NYSE: BX ), Otis Worldwide (NYSE: OTIS ), Honeywell International (NASDAQ: HON ), and Taiwan Semiconductor Manufacturing (NYSE: TSM ). The fund fully exited Northrop Grumman (NYSE...
The ClearBridge Dividend Strategy ( SOPAX ) outperformed the S&P 500 in Q1 2026, as the benchmark fell 4.3% while the portfolio was broadly flat on a gross-of-fees basis. The fund established new positions in Blackstone (NYSE: BX ), Otis Worldwide (NYSE: OTIS ), Honeywell International (NASDAQ: HON ), and Taiwan Semiconductor Manufacturing (NYSE: TSM ). The fund fully exited Northrop Grumman (NYSE: NOC ) and Oracle (NYSE: ORCL ). Source . More on ClearBridge Dividend Strategy Fund A ClearBridge Dividend Strategy Q1 2026 Commentary Dividend scorecard for ClearBridge Dividend Strategy Fund A
Looking at options trading activity among components of the S&P 500 index, there is noteworthy activity today in Salesforce Inc (Symbol: CRM), where a total volume of 65,416 contracts has been traded thus far today, a contract volume which is representative of approximately
Looking at options trading activity among components of the S&P 500 index, there is noteworthy activity today in Salesforce Inc (Symbol: CRM), where a total volume of 65,416 contracts has been traded thus far today, a contract volume which is representative of approximately
May arabica coffee (KCK26 ) today is down -1.90 (-0.65%), and May ICE robusta coffee (RMK26 ) is down -23 (-0.69%). Coffee prices are under pressure today as they consolidate recent losses. On Wednesday, arabica fell to a 3-week low and robusta dropped to an 8-month nearest-futures low amid expectations...
May arabica coffee (KCK26 ) today is down -1.90 (-0.65%), and May ICE robusta coffee (RMK26 ) is down -23 (-0.69%). Coffee prices are under pressure today as they consolidate recent losses. On Wednesday, arabica fell to a 3-week low and robusta dropped to an 8-month nearest-futures low amid expectations...