Andrzej Rostek The US FDA has granted priority review for Ultragenyx Pharmaceutical's ( RARE ) DTX401 AAV gene therapy (pariglasgene brecaparvovec) for Glycogen Storage Disease Type Ia (GSDIa). The FDA action date is Aug. 23. Ultragenyx Chief Medical Officer Eric Crombez said that if approved, DTX401 would be the first therapy approved to treat the root cause of the disease. The application is sup...
Andrzej Rostek The US FDA has granted priority review for Ultragenyx Pharmaceutical's ( RARE ) DTX401 AAV gene therapy (pariglasgene brecaparvovec) for Glycogen Storage Disease Type Ia (GSDIa). The FDA action date is Aug. 23. Ultragenyx Chief Medical Officer Eric Crombez said that if approved, DTX401 would be the first therapy approved to treat the root cause of the disease. The application is supported by data from 52 patients and up to six years of follow-up. Results from a phase 3 trial showed that patients given DTX401 saw significant reductions in the quantity and frequency of daily cornstarch intake, maintained low levels of hypoglycemia, and improved levels of euglycemia and fasting tolerance. More on Ultragenyx Pharmaceutical Ultragenyx Pharmaceutical Inc. (RARE) Q4 2025 Earnings Call Transcript Ultragenyx: From Bone To Brain, Capitulation Creates A Free Option On The Neuro Pipeline Ultragenyx Pharmaceutical Inc. (RARE) Presents at 44th Annual J.P. Morgan Healthcare Conference Transcript Ultragenyx falls as guidance trails consensus amid job cuts Ultragenyx Pharmaceutical GAAP EPS of -$1.29 misses by $0.16, revenue of $207M beats by $5.14M
Mohamad Faizal Bin Ramli/iStock via Getty Images A few years ago, a technical analyst used titles that started with "Sentiment Speaks." While there is a certain trader's simplicity there, I always thought it begged a different question: what impacts sentiment? I was a quant before it was cool, first being recruited in 2002 for a paper I wrote on liquidity factors impacting asset prices, i.e., stoc...
Mohamad Faizal Bin Ramli/iStock via Getty Images A few years ago, a technical analyst used titles that started with "Sentiment Speaks." While there is a certain trader's simplicity there, I always thought it begged a different question: what impacts sentiment? I was a quant before it was cool, first being recruited in 2002 for a paper I wrote on liquidity factors impacting asset prices, i.e., stocks, bonds, and real estate. My broad market thesis in 2002 was that liquidity was increasing again and about to drive asset prices up. From 2003 to 2007, increasing liquidity drove an "everything rally." You can see what happened in 2008 and 2009 when liquidity severely dried up. We got a global financial crisis and the Great Recession. Right now, global liquidity conditions are becoming stressed. For U.S. investors, tightening liquidity could have a significant impact on asset prices in the next few years. As I have discussed in recent articles, including my 2026 outlook , if international investment into American bonds, stocks, and real estate just levels off, asset prices will likely chop or decline. If international investment in the U.S. falls outright, asset prices could head into a deep bear market. Liquidity Drives Asset Prices Evidence from multiple sources augments the correlation of liquidity to asset prices I learned about in college and have observed since. However, people have a hard time analyzing the "long and variable lags" between changes in liquidity and asset price movements. That difficulty leads to disbelief and dismissal. One of the most famous charts was put out by Apollo Global a few years ago. SPY Performance & Fed Balance Sheet (Apollo Global) Let's condense that a bit to really show how tightly things can correlate. Covid QE & SPY (Kirk Spano, FRED) The Federal Reserve balance sheet is not the be-all and end-all of liquidity, though. M2 money supply is the actual driver of asset prices we find. M2, while significantly impacted by central banks, e...
J Studios Enterprise software stocks were largely in the red on Monday amid concerns over competition to their businesses from AI tools. The tech-focused Nasdaq Composite ( COMP:IND ) fell about 0.8%. At the same time, the benchmark S&P 500 ( SP500 ) dipped about 0.9%. The blue-chip Dow ( DJI ) had declined about 1%. Cybersecurity stocks have seen an impact after Anthropic ( ANTHRO ) unveiled a ne...
J Studios Enterprise software stocks were largely in the red on Monday amid concerns over competition to their businesses from AI tools. The tech-focused Nasdaq Composite ( COMP:IND ) fell about 0.8%. At the same time, the benchmark S&P 500 ( SP500 ) dipped about 0.9%. The blue-chip Dow ( DJI ) had declined about 1%. Cybersecurity stocks have seen an impact after Anthropic ( ANTHRO ) unveiled a new feature called Claude Code Security on Friday. CrowdStrike ( CRWD ) slumped about 9%, while Datadog ( DDOG ) tumbled nearly 8%. Cloudflare ( NET ) fell around 5%, while Fortinet ( FTNT ) declined about 4% on Monday. Several other software stocks were also in the red on Monday. Workday ( WDAY ), MongoDB ( MDB ), Atlassian ( TEAM ), and Asana ( ASAN ) each tumbled around 8%. Snowflake ( SNOW ) slumped about 7%, while Pegasystems ( PEGA ) fell nearly 6%. Oracle ( ORCL ), Salesforce ( CRM ), monday.com ( MNDY ), and Elastic ( ESTC ) each declined about 5%, while Palantir Technologies fell around 4%, and Microsoft ( MSFT ) dipped roughly 2%. More on tech stocks Microsoft: Why I Set A $370 Buy Order Microsoft's Plunge Is A Gift Workday: Oversold With Material Upside Potential Microsoft stands out as lone Mag 7 hyperscaler to increase FCF during AI capex splurge: Evercore Workday, Docusign, monday.com, Freshworks downgraded at Jefferies on AI fears
Ofgem says about 140 proposed projects, driven by AI use, could require more power than current peak demand The amount of power being sought by new datacentre projects in the UK would exceed the country’s current peak electricity consumption, according to an industry watchdog. Ofgem said about 140 proposed datacentre schemes, driven by use of artificial intelligence, could require 50 gigawatts of ...
Ofgem says about 140 proposed projects, driven by AI use, could require more power than current peak demand The amount of power being sought by new datacentre projects in the UK would exceed the country’s current peak electricity consumption, according to an industry watchdog. Ofgem said about 140 proposed datacentre schemes, driven by use of artificial intelligence, could require 50 gigawatts of electricity – 5GW more than the country’s current peak demand. Continue reading...
PLAB gears up for Q1 results, with IC strength and AMOLED momentum in focus, but Mainstream IC softness and geopolitical risks are likely to have clouded the outlook.
PLAB gears up for Q1 results, with IC strength and AMOLED momentum in focus, but Mainstream IC softness and geopolitical risks are likely to have clouded the outlook.
沃尔沃汽车周一向路透社证实,将召回超过 4 万辆旗舰电动 SUV EX30,原因是其电池组存在过热风险。此举可能损害这家车企来之不易的安全口碑,并造成数百万美元损失。 此次此前未被报道的召回,涉及更换这款紧凑型 SUV 的高压电池组。EX30 是沃尔沃与价格更低的中国品牌竞争的关键车型。电池安全对电动汽车制造商和消费者而言都是高度敏感问题。 这家由中国吉利控股的瑞典车企在回复路透社提问时表示,共有...
OpenAI's ( OPENAI ) updated capital expenditures for artificial intelligence infrastructure appear positive for hyperscalers Microsoft ( MSFT ) and Oracle ( ORCL ), according to BNP Paribas Equity Research. It was reported OpenAI plans to spend a total of $600B on computing power by 2030. OpenAI CEO Sam Altman said back in October the ChatGPT maker plans to spend as much as $1.4T on infrastructure...
OpenAI's ( OPENAI ) updated capital expenditures for artificial intelligence infrastructure appear positive for hyperscalers Microsoft ( MSFT ) and Oracle ( ORCL ), according to BNP Paribas Equity Research. It was reported OpenAI plans to spend a total of $600B on computing power by 2030. OpenAI CEO Sam Altman said back in October the ChatGPT maker plans to spend as much as $1.4T on infrastructure by 2033. "In our view, the revisions aren't necessarily reflective of a more disciplined OpenAI," said BNP Paribas analyst Stefan Slowinksi in an investor note. "Rather, the updated forecasts appear broadly consistent with the previously announced $1.4T of infrastructure commitments through 2033, with the capital outlays still clearly back-end weighted beyond 2030. With OpenAI potentially aiming to spend $200bn+ annually on compute by 2030, our sense-check calculation suggests OpenAI's original $1.4 trillion figure remains possible." This update paints a mostly positive picture for OpenAI's primary backer, Microsoft ( MSFT ), and OpenAI's primary infrastructure partner, Oracle ( ORCL ). "With a more defined cash burn outlook and OpenAI's $100bn+ capital raise closing soon (with another $80bn likely required thereafter to reach FCF breakeven), we believe this reduces the OpenAI counterparty risk for MSFT/ORCL over the near term," Slowinksi noted. "OpenAI's updated revenue outlook ($280bn target for 2030, with the lift from the previous $200bn coming mainly from enterprise biz) also implies Microsoft should capture an additional $12bn in revenue share by FY30 (+4% vs. Cons), assuming OpenAI can achieve its targets. However, while OpenAI also plans to significantly increase its near-term compute budget, it's unclear whether MSFT/ORCL will directly benefit from this incremental spend, especially with Amazon ( AMZN ) reportedly involved in the current capital raise." More on Microsoft, Oracle and OpenAI Microsoft: Why I Set A $370 Buy Order Microsoft's Plunge Is A Gift Microsof...
Lighthouse Films/DigitalVision via Getty Images RCI Hospitality's ( RICK ) Bombshells Restaurants and Bars continues to be an albatross on its neck with negative same-store sales and an unprofitable operating footprint that makes it hard to recommend a position in the company's common shares, even as it trades at a historically low multiple to trailing twelve months free cash flow. The potential o...
Lighthouse Films/DigitalVision via Getty Images RCI Hospitality's ( RICK ) Bombshells Restaurants and Bars continues to be an albatross on its neck with negative same-store sales and an unprofitable operating footprint that makes it hard to recommend a position in the company's common shares, even as it trades at a historically low multiple to trailing twelve months free cash flow. The potential of the full divestment of Bombshells represented a possible salvo for bulls, but the operating unit remains part of the financials, with RICK reporting fiscal 2026 first-quarter total revenue, which ended December 31, 2025, of $70.3 million . This is problematic because it dipped by 1.70% from revenue of $71.5 million in the year-ago comp. This dip was mainly driven by weakness in revenue from Bombshells, with management also pinning the blame for this quarter's weakness on the 2025 Government Shutdown. The company has previously blamed hot weather in Texas, with the bulk of its clubs and Bombshells restaurants located in the Lone Star State. Data by YCharts Data by YCharts The company is also paying a quarterly cash dividend of $0.07 per share , for an annualized yield of around 1.2% against the current trading price of the commons. RICK has been pretty consistent with this distribution and has actually expanded this at a roughly 12% compound annual growth rate over the last three years. This yield has moved up to its highest-ever level on the back of its stock price weakness, shifting what was previously a peppercorn dividend distribution against the 52-week high to see the ticker included in income screeners to a more hefty level of income. Further, the company's price-to-trailing twelve months free cash flow has fallen to its lowest level in more than five years at 6x. This represents the base of the bull case for RICK. You can essentially buy a business that's generating positive free cash flow at its lowest-ever valuation as it continues to chase growth through an expa...